Spider-Man 3 smashed U.S. box office records last weekend, netting $148 million in its first three days of release.
The tally beats the previous record of $135.6 million, set last summer by Pirates Of The Caribbean: Dead Man's Chest.
The web-slinging hero has also proven irresistable overseas, grossing $375 million globally. This represents a profit of $117 million, allowing for the film's production budget of $258 million.
Further records may fall in the next 10 days, with no major competition in sight until the May 18 premiere of the animated comedy Shrek The Third.
The previous U.S. champion, Disturbia, ranked a distant second last weekend with $5.7 million in box office grosses. The figure raises its three-week total to $59.9 million.