Witnesses and Egyptian medics say at least one protester was shot dead and dozens of others injured Friday outside the presidential palace in Cairo, as riot police clashed with anti-government demonstrators.
Television footage showed protesters throwing gasoline bombs and fireworks at the outer wall of of the palace, while police used water cannon and tear gas in nearby streets to hold off protesters. At least one building inside the outer wall of the presidential compound briefly caught fire.
Medical authorities said a 23-year-old demonstrator died of gunshot wounds near the palace and said at least 53 others sustained injuries.
The renewed violence shattered several days of calm after the deadliest week of protests in key Egyptian cities since President Mohamed Morsi came to power seven months ago.
Nearly 60 people have been killed in key cities along the Suez Canal since January 25, when anti-Morsi protesters took to the streets to mark the second anniversary of the uprising that toppled the regime of former president Hosni Mubarak.
Protesters accuse Mr. Morsi and his hardline Muslim Brotherhood supporters of betraying the spirit of the 2011 Arab Spring protests, which swept through much of North Africa driven by demands for wholesale democratic reforms.
Egypt's largely-secularist opposition leaders have called on Mr. Morsi to form a national unity government that grants them seats in the Cabinet.
The president's allies have resisted that demand, saying the opposition is trying to gain power that it could not win through elections.
On Thursday, Egypt's Islamist and liberal politicians agreed to renounce violence and join a national dialogue aimed at resolving the country's deadliest unrest in months.
Leading opposition figure Mohamed ElBaradei voiced optimism after Thursday's meeting and promised to do whatever he can to promote goodwill and build trust between the factions.