News / Health

Blocking Pain at its Source

Research for new painkiller finds inspiration in chili peppers

Inspired by chili peppers, researchers are working toward a painkiller that could stop the brain from registering the presence of pain.
Inspired by chili peppers, researchers are working toward a painkiller that could stop the brain from registering the presence of pain.

Multimedia

Audio

Anyone who has ever had to recover from surgery or a serious injury was probably grateful for the powerful narcotics doctors prescribed to help ease the pain. But all these medications do is dull the brain's perception of pain.

Your brain registers pain through neurons, special cells that wind through the body. When you touch boiling water, for example, get a cut, or even exercise too much, a special receptor on the neuron is activated, sending a signal to the brain — that hurts!.

This much scientists knew. However, they were not clear on how that receptor was activated when this kind of painful event occurred.

The chili pepper model

University of Texas researcher Kenneth Hargreaves says they got an important clue from chili peppers.

He explains that, while people think of the capsaicin from chili peppers as a spice, "it is actually a selective drug. It really produces its effects primarily by just activating the so-called capsaicin receptor."

When we eat chili peppers, we feel a burning sensation. That feeling is caused by the capsaicin molecules in the peppers activating the capsaicin receptors on our tongue — the more capsaicin, the hotter the pepper.

In the course of an entirely different experiment, Hargreaves and his team of researchers discovered that the skin produces its own capsaicin-like molecules, in response to pain.

"We took isolated skin biopsies from laboratory mice, exposed those isolated skin biopsies to temperatures of 43 degrees or 48 degrees, and then we looked at what was being released from the skin under those conditions." Heat typically becomes painful at about 47 degrees Celsius.

When the skin samples were heated to 48 degrees, they produced this capsaicin-like molecule into a solution. Then, Hargreaves says, the researchers applied the solution to mice neurons; some with the capsaicin-receptor and some that had been genetically modified to eliminate that receptor.

"The ability of these substances to activate pain neurons was totally dependent upon capsaicin receptor," says Hargreaves.

A new approach to treating pain

Hargreaves says this is a huge discovery, one that could fundamentally change how doctors treat pain. "Now that we have discovered the endogenous capsaicin molecules, for the first time, we can block their synthesis and therefore we can treat pain at its cause."

Narcotics, the most powerful drugs currently available to fight pain, simply dull the brain's perception of it. But if a medication can block the capsaicin-like molecule from reaching the neuron, it could stop the brain from ever registering there was any pain to begin with.

Hargreaves and his team are already in the process of developing two classes of drugs that do just that. One would stop the body from producing the capsaicin molecule. Another would soak it up, before it reached the receptor on the neuron.

And crucially, these drugs do not seem to have the same potential to become addictive, the way narcotics do. Hargreaves says the first class of drugs could begin clinical tests in humans within the next six months.

You May Like

Brutality Eroding IS Financial Support

Director of National Intelligence James Clapper says IS's penchant for publicizing beheadings, other brutal forms of punishment hurts group’s bottom line More

Studies: Climate Change a Factor in Disasters in Syria, California

The studies point to the possibility of clear and present dangers from a threat often considered to be far in the future More

Video Afghan Refugees Complain of Harassment in Pakistan

Afghan officials and human rights organizations assert that Pakistani authorities are using deadly attack at school in Peshawar as pretext to push out Afghan refugees More

This forum has been closed.
Comments
     
There are no comments in this forum. Be first and add one

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
Kerry Seeks Assurances of Russian Non-Interference in Ukrainei
X
March 03, 2015 3:11 AM
U.S. Secretary of State John Kerry has told his Russian counterpart, Sergei Lavrov, that his country could face further consequences to what he called its “already strained economy” if Moscow does not fully comply with a cease-fire in Ukraine. The two met, on Monday, on the sidelines of a U.N. Human Rights Council meeting in Geneva, where Kerry outlined human rights violations in Russian-annexed Crimea and eastern Ukraine. VOA State Department correspondent Pam Dockins reports from Geneva.
Video

Video Kerry Seeks Assurances of Russian Non-Interference in Ukraine

U.S. Secretary of State John Kerry has told his Russian counterpart, Sergei Lavrov, that his country could face further consequences to what he called its “already strained economy” if Moscow does not fully comply with a cease-fire in Ukraine. The two met, on Monday, on the sidelines of a U.N. Human Rights Council meeting in Geneva, where Kerry outlined human rights violations in Russian-annexed Crimea and eastern Ukraine. VOA State Department correspondent Pam Dockins reports from Geneva.
Video

Video Smartphones May Help in Diagnosing HIV

Diagnosing infections such as HIV requires expensive clinical tests, making the procedure too costly for many poor patients or those living in remote areas. But a new technology called lab-on-a-chip may make the tests more accessible to many. VOA’s George Putic reports.
Video

Video Afghan Refugees Complain of Harassment in Pakistan

Afghan officials have expressed concern over reports of a crackdown on Afghan refugees in Pakistan following the Peshawar school attack in December. Reports of mass arrests and police harassment coupled with fear of an uncertain future are making life difficult for a population that fled its homeland to escape war. VOA’s Ayesha Tanzeem reports from Islamabad.
Video

Video Ukrainian Volunteers Prepare to Defend Mariupol

Despite the ongoing ceasefire in Ukraine, soldiers in the city of Mariupol fear that pro-Russian separatists may be getting ready to attack. The separatists must take or encircle the city if they wish to gain land access to Crimea, which was annexed by Russia early last year. But Ukrainian forces, many of them volunteers, say they are determined to defend it. Patrick Wells reports from Mariupol.
Video

Video Moscow Restaurants Suffer in Bad Economy, Look for Opportunity

As low oil prices and Western sanctions force Russia's economy into recession, thousands of Moscow restaurants are expected to close their doors. Restaurant owners face rents tied to foreign currency, while rising food prices mean Russians are spending less when they dine out. One entrepreneur in Moscow has started a dinner kit delivery service for those who want to cook at home to save money but not skimp on quality. VOA's Daniel Schearf reports.
Video

Video US, Cuba Report Progress in Latest Talks to Restore Ties

The United States and Cuba say they have made progress in the second round of talks on restoring diplomatic relations more than 50 years after breaking off ties. Delegations from both sides met in Washington on Friday to work on opening embassies in Havana and Washington and iron out key obstacles to historic change. VOA’s Mary Alice Salinas reports from the State Department.
Video

Video Presidential Hopefuls Battle for Conservative Hearts and Minds

One after another, presumptive Republican presidential contenders auditioned for conservative support this week at the Conservative Political Action Conference held outside Washington. The rhetoric was tough as a large field of potential candidates tried to woo conservative support with red-meat attacks on President Barack Obama and Democrats in Congress. VOA Political Columnist Jim Malone takes a look.
Video

Video NYC's Restaurant Week: An Economic Boom in Fine Dining

New Yorkers take pride in setting world trends — in fashion, the arts and fine dining. The city’s famous biannual Restaurant Week plays a significant role in a booming tourism industry that sustains 359,000 jobs and generates $61 billion in yearly revenue. VOA's Ramon Taylor reports.
Video

Video Brookhaven at Cutting Edge of US Energy Research

Issues like the Keystone XL pipeline, fracking and instability in the Middle East are driving debate in the U.S. about making America energy independent. Recently, the American Energy Innovation Council urged Congress and the White House to make expanded energy research a priority. One beneficiary of increased energy spending would be the Brookhaven National Lab, where clean, renewable, efficient energy is the goal. VOA's Bernard Shusman reports.
Video

Video Southern US Cities Preserve Civil Rights Heritage to Boost Tourism

There has been a surge of interest in the American civil rights movement of the 1950s and '60s, thanks in part to the Hollywood motion picture "Selma." Five decades later, communities in the South are embracing the dark chapters of their past with hopes of luring tourism dollars. VOA's Chris Simkins reports.
Video

Video Deep Under Antarctic Ice Sheet, Life!

With the end of summer in the Southern hemisphere, the Antarctic research season is over. Scientists from Northern Illinois University are back in their laboratory after a 3-month expedition on the Ross Ice Shelf, the world’s largest floating ice sheet. As VOA’s Rosanne Skirble reports, they hope to find clues to explain the dynamics of the rapidly melting ice and its impact on sea level rise.
Video

Video Lao Dam Project Runs Into Opposition

A Lao dam project on a section of the Mekong River is drawing opposition from local fishermen, international environmental groups and neighboring countries. VOA's Say Mony visited the region to investigate the concerns. Colin Lovett narrates.

All About America

Circumventing Censorship

An Internet Primer for Healthy Web Habits

As surveillance and censoring technologies advance, so, too, do new tools for your computer or mobile device that help protect your privacy and break through Internet censorship.
More