News / Health

    Blocking Pain at its Source

    Research for new painkiller finds inspiration in chili peppers

    Inspired by chili peppers, researchers are working toward a painkiller that could stop the brain from registering the presence of pain.
    Inspired by chili peppers, researchers are working toward a painkiller that could stop the brain from registering the presence of pain.

    Multimedia

    Audio

    Anyone who has ever had to recover from surgery or a serious injury was probably grateful for the powerful narcotics doctors prescribed to help ease the pain. But all these medications do is dull the brain's perception of pain.

    Your brain registers pain through neurons, special cells that wind through the body. When you touch boiling water, for example, get a cut, or even exercise too much, a special receptor on the neuron is activated, sending a signal to the brain — that hurts!.

    This much scientists knew. However, they were not clear on how that receptor was activated when this kind of painful event occurred.

    The chili pepper model

    University of Texas researcher Kenneth Hargreaves says they got an important clue from chili peppers.

    He explains that, while people think of the capsaicin from chili peppers as a spice, "it is actually a selective drug. It really produces its effects primarily by just activating the so-called capsaicin receptor."

    When we eat chili peppers, we feel a burning sensation. That feeling is caused by the capsaicin molecules in the peppers activating the capsaicin receptors on our tongue — the more capsaicin, the hotter the pepper.

    In the course of an entirely different experiment, Hargreaves and his team of researchers discovered that the skin produces its own capsaicin-like molecules, in response to pain.

    "We took isolated skin biopsies from laboratory mice, exposed those isolated skin biopsies to temperatures of 43 degrees or 48 degrees, and then we looked at what was being released from the skin under those conditions." Heat typically becomes painful at about 47 degrees Celsius.

    When the skin samples were heated to 48 degrees, they produced this capsaicin-like molecule into a solution. Then, Hargreaves says, the researchers applied the solution to mice neurons; some with the capsaicin-receptor and some that had been genetically modified to eliminate that receptor.

    "The ability of these substances to activate pain neurons was totally dependent upon capsaicin receptor," says Hargreaves.

    A new approach to treating pain

    Hargreaves says this is a huge discovery, one that could fundamentally change how doctors treat pain. "Now that we have discovered the endogenous capsaicin molecules, for the first time, we can block their synthesis and therefore we can treat pain at its cause."

    Narcotics, the most powerful drugs currently available to fight pain, simply dull the brain's perception of it. But if a medication can block the capsaicin-like molecule from reaching the neuron, it could stop the brain from ever registering there was any pain to begin with.

    Hargreaves and his team are already in the process of developing two classes of drugs that do just that. One would stop the body from producing the capsaicin molecule. Another would soak it up, before it reached the receptor on the neuron.

    And crucially, these drugs do not seem to have the same potential to become addictive, the way narcotics do. Hargreaves says the first class of drugs could begin clinical tests in humans within the next six months.

    You May Like

    US-Russia Tensions Complicate Syria War

    With a shared enemy and opposing allies, Russia and the US are working to avoid confrontation

    Video Re-opening Old Wounds in Beirut's Bullet-riddled Yellow House

    Built in neo-Ottoman style in 1920s, it is set to be re-opened in Sept. as ‘memory museum’ - bullet-riddled walls and bunkered positions overlooking city’s notorious ‘Green Line’ maintained for posterity

    Cambodian-Americans Lobby for Human Rights Resolution

    Resolution condemns all forms of political violence in Cambodia, urges Cambodian government to end human rights violations, calls for respect of press freedom

    This forum has been closed.
    Comments
         
    There are no comments in this forum. Be first and add one

    Featured Videos

    Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
    Brexit Vote Plunges Global Markets Into Uncharted Territoryi
    X
    June 24, 2016 9:38 PM
    British voters plunged global markets into unknown territory after they voted Thursday to leave the European Union. The results of the Brexit vote, the term coined to describe the referendum, caught many off guard. Analysts say the resulting volatility could last for weeks, perhaps longer. Mil Arcega reports.
    Video

    Video Brexit Vote Plunges Global Markets Into Uncharted Territory

    British voters plunged global markets into unknown territory after they voted Thursday to leave the European Union. The results of the Brexit vote, the term coined to describe the referendum, caught many off guard. Analysts say the resulting volatility could last for weeks, perhaps longer. Mil Arcega reports.
    Video

    Video Orlando Shooting Changes Debate on Gun Control

    It’s been nearly two weeks since the largest mass shooting ever in the United States. Despite public calls for tighter gun control laws, Congress is at an impasse. Democratic lawmakers resorted to a 1960s civil rights tactic to portray their frustration. VOA’s Carolyn Presutti explains how the Orlando, Florida shooting is changing the debate.
    Video

    Video Tunisian Fishing Town Searches for Jobs, Local Development Solutions

    As the European Union tries to come to grips with its migrant crisis, some newcomers are leaving voluntarily. But those returning to their home countries face an uncertain future.  Five years after Tunisia's revolution, the tiny North African country is struggling with unrest, soaring unemployment and plummeting growth. From the southern Tunisian fishing town of Zarzis, Lisa Bryant takes a look for VOA at a search for local solutions.
    Video

    Video 'American Troops' in Russia Despite Tensions

    Historic battle re-enactment is a niche hobby with a fair number of adherents in Russia where past military victories are played-up by the Kremlin as a show of national strength. But, one group of World War II re-enactors in Moscow has the rare distinction of choosing to play western ally troops. VOA's Daniel Schearf explains.
    Video

    Video Experts: Very Few Killed in US Gun Violence Are Victims of Mass Shootings

    The deadly shooting at a Florida nightclub has reignited the debate in the U.S. over gun control. Although Congress doesn't provide government health agencies funds to study gun violence, public health experts say private research has helped them learn some things about the issue. VOA's Carol Pearson reports.
    Video

    Video Trump Unleashes Broadside Against Clinton to Try to Ease GOP Doubts

    Recent public opinion polls show Republican Donald Trump slipping behind Democrat Hillary Clinton in the presidential election matchup for November. Trump trails her both in fundraising and campaign organization, but he's intensifying his attacks on the former secretary of state. VOA National Correspondent Jim Malone reports.
    Video

    Video Muslim American Mayor Calls for Tolerance

    Syrian-born Mohamed Khairullah describes himself as "an American mayor who happens to be Muslim." As the three-term mayor of Prospect Park, New Jersey, he believes his town of 6,000 is an example of how ethnicity and religious beliefs should not determine a community's leadership. Ramon Taylor has this report from Prospect Park.
    Video

    Video Internal Rifts Over Syria Policy Could Be Headache for Next US President

    With the Obama administration showing little outward enthusiasm for adopting a more robust Syria policy, there is a strong likelihood that the internal discontent expressed by State Department employees will roll over to the next administration. VOA State Department correspondent Pam Dockins reports.
    Video

    Video Senegal to Park Colorful ‘Cars Rapide’ Permanently

    Brightly painted cars rapide are a hallmark of Dakar, offering residents a cheap way to get around the capital city since 1976. But the privately owned minibuses are scheduled to be parked for good in late 2018, as Ricci Shryock reports for VOA.
    Video

    Video Florida Gets $1 Million in Emergency Government Funding for Orlando

    The U.S. government has granted $1 million in emergency funding to the state of Florida to cover the costs linked to the June 12 massacre in Orlando. U.S. Attorney General Loretta Lynch announced the grant Tuesday in Orlando, where she met with survivors of the shooting attack that killed 49 people. Zlatica Hoke reports.
    Video

    Video How to Print Impossible Shapes with Metal

    3-D printing with metals is rapidly becoming more advanced. As printers become more affordable, the industry is partnering with universities to refine processes for manufacturing previously impossible things. A new 3-D printing lab aims to bring the new technology closer to everyday use. VOA's George Putic reports.
    Video

    Video Big Somali Community in Minnesota Observes Muslim Religious Feast

    Ramadan is widely observed in the north central US state of Minnesota, which a large Muslim community calls home. VOA Somali service reporter Mohmud Masadde files this report from Minneapolis, the state's biggest city.

    Special Report

    Adrift The Invisible African Diaspora