News / Africa

Math May Determine Best HIV Drug Combinations

Patient, who is suffering from AIDS, lies on a bed at the state hospital in Congo's capital of Kinshasa, October 2006. Researchers hope new mathematical formula will allow doctors to use the best combinations of antiretroviral drugs for treatment. (file p
Patient, who is suffering from AIDS, lies on a bed at the state hospital in Congo's capital of Kinshasa, October 2006. Researchers hope new mathematical formula will allow doctors to use the best combinations of antiretroviral drugs for treatment. (file p
Joe DeCapua

Treating people infected with the AIDS virus involves using a combination of antiretroviral drugs. But some combinations work better than others. Now, a mathematical formula has been developed that may eventually help doctors decide which drugs to use.

Prescribing a cocktail of drugs has become the gold standard in preventing HIV from replicating. It’s called HAART, which stands for highly active antiretroviral therapy. The cocktail combinations may be changed periodically to prevent the virus from building up resistance.

The new math

The new mathematical formula is based on a 5-year analysis of how the drugs keep HIV in check.

Dr. Robert Siliciano, Profess of medicine, Johns Hopkins
Dr. Robert Siliciano, Profess of medicine, Johns Hopkins

Dr. Robert Siliciano, senior study investigator and a specialist in infectious disease, said, “I’ve always been interested in why some combinations of HIV drugs work well and some don’t. Most of the progress in the HIV treatment field in terms of deciding which treatments should be used in patients has been based on empirical studies – trial and error clinical trials – in which different combinations are tested against each other. And you look at how many patients after one year of treatment have (an) undetectable level of virus.”

Siliciano is a professor of medicine at Johns Hopkins University.

“There hasn’t been a lot of theoretical basis of why some combinations should work better than others. [With] what we know about how the virus replicates, it should be possible at least to predict some aspects of treatment outcome, specifically how well the drugs actually inhibit the virus,” he said.

What works, what doesn’t

The study analyzed how well individual drugs and drug combinations inhibit infection. Researchers then fed that data into computers and applied their mathematical formula.

“The standard way to do this is to look at the amount of drug that gives you 50 percent inhibition. That turns out to be a very poor way of doing it because at least some of the drugs are actually extremely good and they cause way, way more than 50 percent inhibition,” he said.

In fact, some drugs are more than 99 percent effective in inhibiting HIV from replicating. Those are the antiretrovirals included in the study.

“Because the virus replicates exponentially,” said Siliciano, “it can increase very, very quickly, and so that’s why you need that extremely high level of inhibition.”

Siliciano and his fellow researchers used 19 drugs and came up with well over 800 treatment combinations. He said while more study of the mathematical formula is needed, he foresees two uses. The first, of course, is treatment.

“Actually most of the people who have HIV infection are not on treatment right now. And treatments are not available in many areas. And the treatments are very costly and complicated. So if you really understand how well individual drugs and drug combinations work, it may be possible to figure out what is the simplest treatment that would be effective and that could be made more widely available,” he said.

The formula could also help prevent drug resistance.

“Resistance is a very big problem when people either don’t get an adequate supply of drugs or don’t take the drugs correctly. Resistance can develop very easily. And the current ways of evaluating what to do for patients who have resistance need to be improved and this mathematical analysis I think gives us a way to do that,” he said.

He said the next focus will be to come up with a drug regimen against which HIV is unable to develop any resistance.

You May Like

Hostage Crisis Could Divide Japan Over Plans to Boost Military

Japanese Chief Cabinet Secretary Yoshihide Suga said Monday the government is working closely with the Jordanian government to secure the release of remaining Japanese hostage Kenji Goto More

Video Brussels Shaken as New Greek Leader Challenges Europe’s Austerity Drive

Country's youngest ever PM Alexis Tsipras, 40, sworn in Monday and says he will restore dignity to Greece by ending spending cuts More

Multimedia National Geographic Photo Camps Empower Youth

Annual mentoring program's mission is to give young people a voice to tell their own stories through photography More

This forum has been closed.
Comments
     
There are no comments in this forum. Be first and add one

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
Obama Urges Closer Economic Ties During Historic India Visiti
X
Aru Pande
January 26, 2015 9:33 PM
U.S. President Barack Obama says the United States and India must do better to capitalize on untapped potential in their economic relationship - by removing some of the roadblocks to greater trade and investment. As VOA correspondent Aru Pande reports from New Delhi, Obama spoke after participating in India’s Republic Day celebration.
Video

Video Obama Urges Closer Economic Ties During Historic India Visit

U.S. President Barack Obama says the United States and India must do better to capitalize on untapped potential in their economic relationship - by removing some of the roadblocks to greater trade and investment. As VOA correspondent Aru Pande reports from New Delhi, Obama spoke after participating in India’s Republic Day celebration.
Video

Video US, EU Threaten New Russia Sanctions Over Ukraine

U.S. President Barack Obama has blamed Russia for an attack by Ukrainian separatists that left dozens dead in the port of Mariupol and cast further doubt on the viability of last year’s cease-fire with the Kyiv government. VOA’s Michael Bowman reports from Washington.
Video

Video White House Grapples With Yemen Counterterrorism Strategy

Reports say the U.S. has carried out a drone strike on suspected militants in Yemen, the first after President Barack Obama offered reassurances the U.S. is continuing its counterterrorism operations in the country. The future of those operations has been in question following the collapse last week of Yemen’s government. VOA White House correspondent Luis Ramirez reports.
Video

Video Kerry Warns Against Violence in Nigeria Election

US Secretary of State John Kerry visited Nigeria Sunday in a show of the level of concern within the U.S. and the international community over next month’s presidential election. Chris Stein reports.
Video

Video Zoo Animals Show Their Artistic Sides

The pursuit of happiness is so important, America's founding fathers put it in the Declaration of Independence. Any zookeeper will tell you animals need enrichment, just like humans do. So painting, and even music, are part of the Smithsonian National Zoo's program to keep the animals happy. VOA’s June Soh met some animal artists at the zoo in Washington. Faith Lapidus narrates.
Video

Video Worldwide Photo Workshops Empower Youth

Last September, 20 young adults from South Sudan took part in a National Geographic Photo Camp. They are among hundreds of students from around the world who have learned how to use a camera to tell the stories of the people in their communities through the powerful medium of photography. Three camp participants talked about their experiences recently on a visit to Washington. VOA’s Julie Taboh reports.
Video

Video Saudi, Yemen Developments Are Sudden Complications for Obama

The death of Saudi Arabia's King Abdullah and the collapse of Yemen’s government have cast further uncertainty on U.S. efforts to fight militants in the Middle East and also contain Iran’s influence in the region. VOA White House correspondent Luis Ramirez reports on the new complications facing the Obama administration and its Middle East policy.
Video

Video Progress, Some Areas of Disagreement in Cuba Talks

U.S. and Cuban officials are reporting progress from initial talks in Havana on re-establishing diplomatic ties. U.S. Assistant Secretary of State (for Western Hemisphere Affairs) Roberta Jacobson said while there was agreement on a broad range of issues, there also are some “profound disagreements” between Washington and Havana. VOA State Department correspondent Pam Dockins has the story.
Video

Video US, Japan Offer Lessons as Eurozone Launches Huge Stimulus

The Euro currency has fallen sharply after the European Central Bank announced a bigger-than-expected $67 billion-a-month quantitative easing program Thursday - commonly seen as a form of printing new money. Henry Ridgwell reports for VOA from London on whether the move might rescue the eurozone economy -- and what lessons have been learned from similar programs around the world.
Video

Video Nigerian Elections Pose Concern of Potential Conflict in 'Middle Belt'

Nigeria’s north-central state of Kaduna has long been the site of fighting between Muslims and Christians as well as between people of different ethnic groups. As the February elections approach, community and religious leaders are making plans they hope will keep the streets calm after results are announced. Chris Stein reports from the state capital, Kaduna.
Video

Video As Viewership Drops, Obama Puts His Message on YouTube

Ratings reports show President Obama’s State of the Union address this week drew the lowest number of viewers for this annual speech in 15 years. White House officials anticipated this, and the president has decided to take a non-traditional approach to getting his message out. VOA White House correspondent Luis Ramirez reports.
Video

Video S. Korean Businesses Want to End Trade Restrictions With North

Business leaders in South Korea are calling for President Park Geun-hye to ease trade restrictions with North Korea that were put in place in 2010 after the sinking of a South Korean warship.Pro-business groups argue that expanding trade and investment is not only good for business, it is also good for long-term regional peace and security. VOA’s Brian Padden reports.

Circumventing Censorship

An Internet Primer for Healthy Web Habits

As surveillance and censoring technologies advance, so, too, do new tools for your computer or mobile device that help protect your privacy and break through Internet censorship.
More

All About America

AppleAndroid