News / Health

    Frog Skin Oozes Possibly Powerful Antibiotic

    Amphibians secrete new weapon for drug arsenal

    The skin of certain frogs, including this foothill yellow-legged frog, contains secretions that may lead to new antibiotics to fight infections that shrug off the effects of existing antibiotics.
    The skin of certain frogs, including this foothill yellow-legged frog, contains secretions that may lead to new antibiotics to fight infections that shrug off the effects of existing antibiotics.

    Multimedia

    Audio
    Rosanne Skirble

    Frogs secrete compounds that could be used to battle MRSA and a new emerging bacterium that affects many wounded soldiers in Iraq.

    According to Mideast researchers, the amphibians could provide several new antibiotic compounds to fight drug resistant fungi and bacteria.

    Worldwide threat

    The emerging battle against drug-resistant bacteria poses a huge threat to public health worldwide. That threat has loomed larger as the number of effective antibiotic drugs has dwindled.  

    J. Michael Conlon, a biochemist at the United Arab Emirates University, says frog skin, which protects the amphibians from injury and disease, is coming to the rescue by providing a wealth of new antibiotic compounds to fight drug resistant fungi and bacteria.

    "Frogs of necessity have to live in a warm moist environment that is very conducive to the growth of micro-organisms. They've been around for a long, long time, at least 300 million years" says Conlon. "So, it's not so surprising that, over the course of evolution, they have developed defenses against these invading pathogens."  

    Conlon has identified germ-fighting chemicals from more than 200 frog species from around the world by isolating peptides or strings of proteins that have the ability to kill bacteria and fungi.

    He says the challenge is to get those agents to work in humans. "The problem is that as well as efficiently killing micro-organisms, they are to various degrees toxic to mammalian cells.  So it's not a great idea to cure infection if you kill the patient at the same time."  

    Fighting two major pathogens

    Conlon's laboratory in the United Arab Emirates works with samples from frogs gathered collaboratively by scientists in Japan, France and the United States.

    The naturally occurring compounds are first purified and then synthesized. At that point, structural changes are made in the molecules. The results have proved to be less toxic to human cells.

    Conlon says the new compounds show promise in fighting two major pathogens, the well known methicillin-resistant Staphylococcus aureus (MRSA) and a new emerging bacterium, Acintobacter baumanni. "This has been called the Iraqibacter because many wounded soldiers in Iraq have developed infections by this microorganism."  

    Frog mouthwash

    Conlon also sees great potential for other antibiotic applications from creams and ointments for wounds to treatment of foot ulcers.  He adds that the peptides have shown to be very effective against oral pathogens. "So we are interested in the possibility of incorporating of incorporating them into a mouth wash."

    But Conlon says as a researcher in a small university lab, he can only take the product so far.  "To bring a drug from the laboratory to the pharmacy literally costs hundreds of millions of dollars. We really need a partner in the pharmaceutical industry with which to collaborate."   

    Should that partner step forward, J. Michael Conlon predicts that some frog-skin derived compounds could make their way into clinical trials and into marketable drugs within five years.

    You May Like

    Turkey, West in Standoff Over Syrian Refugees

    Turkish government refuses to admit refugees, the first in a wave of civilians fleeing offensive by Assad regime in northern Aleppo countryside

    Jailed American Testifies About Islamist Involvement in Mumbai Attacks

    David Headley testifies via video link that Pakistan-based Islamic terror group made two failed attempts to mount strikes in Mumbai in months prior to coordinated assault

    These Are the 10 Smartest US States

    A new report breaks down the nation's best and brightest

    This forum has been closed.
    Comments
         
    There are no comments in this forum. Be first and add one

    Featured Videos

    Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
    German Artists to Memorialize Refugees With Life Jacket Exhibiti
    X
    Hamada Elsaram
    February 05, 2016 4:30 PM
    Sold in every kind of shop in some Turkish port towns, life jackets have become a symbol of the refugee crisis that brought a million people to Europe in 2015.  On the shores of Lesbos, Greece, German artists collect discarded life jackets as they prepare an art installation they plan to display in Germany.  For VOA, Hamada Elrasam has this report from Lesbos, Greece.
    Video

    Video German Artists to Memorialize Refugees With Life Jacket Exhibit

    Sold in every kind of shop in some Turkish port towns, life jackets have become a symbol of the refugee crisis that brought a million people to Europe in 2015.  On the shores of Lesbos, Greece, German artists collect discarded life jackets as they prepare an art installation they plan to display in Germany.  For VOA, Hamada Elrasam has this report from Lesbos, Greece.
    Video

    Video E-readers Help Ease Africa's Book Shortage

    Millions of people in Africa can't read, and there's a chronic shortage of books. A non-profit organization called Worldreader is trying to help change all that one e-reader at a time. VOA’s Deborah Block tells us about a girls' school in Nairobi, Kenya where Worldreader is making a difference.
    Video

    Video Genius Lets World Share Its Knowledge

    Inspired by crowdsourcing companies like Wikipedia, Genius allows anyone to edit anything on the web, using its web annotation tool
    Video

    Video Former Drug CEO Martin Shkreli Angers US Lawmakers

    A former U.S. pharmaceutical business executive has angered lawmakers by refusing to explain why he raised the price of a life-saving pill by 5,000 percent. Martin Shkreli was removed from a congressional hearing on Thursday after citing his Fifth Amendment right to stay silent. Zlatica Hoke has more.
    Video

    Video Super Bowl TV Commercials are Super Business for Advertisers

    The Super Bowl, the championship clash between the two top teams in American Football, is the most-watched sporting event of the year, and advertisers are lining up and paying big bucks to get their commercials on the air. In fact, the TV commercials during the Super Bowl have become one of the most anticipated and popular features of the event. VOA's Brian Allen has a sneak peek of what you can expect to see when the big game goes to commercial break, and the real entertainment begins.
    Video

    Video In Philippines, Mixed Feelings About Greater US Military Presence

    In the Philippines, some who will be directly affected by a recent Supreme Court decision clearing the way for more United States troop visits are having mixed reactions.  The increased rotations come at a time when the Philippines is trying to build up its military in the face of growing maritime assertiveness from China.  From Bahile, Palawan on the coast of the South China Sea, Simone Orendain has this story.
    Video

    Video Microcephaly's Connection to Zika: Guilty Until Proven Innocent

    The Zika virus rarely causes problems for the people who get it, but it seems to be having a devastating impact on babies whose mothers are infected with Zika. VOA's Carol Pearson has more.
    Video

    Video Solar Innovation Provides Cheap, Clean Energy to Kenya Residents

    In Kenya, a company called M-Kopa Solar is providing clean energy to more than 300,000 homes across East Africa by allowing customers to "pay-as-you-go" via their cell phones. As Lenny Ruvaga reports from Kangemi, customers pay a small deposit for a solar unit and then pay less than a dollar a day to get clean energy to light up their homes or businesses.
    Video

    Video Stunning Artworks Attract Record Crowds, Thanks to Social Media

    A new exhibit at the oldest art museum in America is shattering attendance records. Thousands of visitors are lining up to see nine giant works of art that have gotten a much-deserved shot of viral marketing. The 150-year-old Smithsonian American Art Museum has never had a response quite like this. VOA's Julie Taboh reports.
    Video

    Video Apprenticeships Put Americans on Path Back to Work

    Trying to get more people into the U.S. workforce, the Obama administration last year announced $175 million in grants towards apprenticeship programs. VOA White House correspondent Aru Pande went inside one training center outside of Washington that has gained national recognition for helping put people on the path to employment.
    Video

    Video New Material May Reduce Concussion Effects

    As the 2016 National Football League season reaches its summit at the Super Bowl this coming Sunday (2/7), scientists are trying to learn how to more effectively protect football players from dangerous and damaging concussions. Researchers at Cardiff and Cambridge Universities say their origami-based material may solve the problem. VOA’s George Putic reports.
    Video

    Video Saudi Arabian Women's Sports Chip Away at Stereotypes

    Saudi Arabian female athletes say that sports are on the front line of busting traditions that quash women’s voices, both locally and internationally. In their hometown of Jeddah, a group of basketball players say that by connecting sports to health issues, they are encouraging women and girls to get out of their homes and participate in public life. VOA’s Heather Murdock reports.
    Video

    Video A Year Later, Fortunes Mixed for Syrians Forging New Lives in Berlin

    In April of last year, VOA followed the progress of six young Syrian refugees -- four brothers and their two friends -- as they made their way from Libya to Italy by boat, and eventually to Germany. Reporter Henry Ridgwell caught up with the refugees again in Berlin, as they struggle to forge new lives amid the turmoil of Europe's refugee crisis.
    Video

    Video Zika Virus May be Hard to Stop

    With the Zika virus spreading rapidly, the World Health Organization Monday declared Zika a global health emergency. As Alberto Pimienta reports, for many governments and experts, the worst is yet to come.