News / Health

Inhaling Tuberculosis Drugs Could Be More Effective

Delivering medicine directly to the lungs is faster and requires lower doses

Delivering TB drugs directly to the lungs by inhaling a fine powder,  can be more effective, faster and require lower doses.
Delivering TB drugs directly to the lungs by inhaling a fine powder, can be more effective, faster and require lower doses.

Multimedia

Audio
Art Chimes

A new way of taking tuberculosis drugs shows promise in laboratory tests. Instead of taking a pill or getting a shot, patients would inhale their medicine to get the drug deep into the lungs.

Tuberculosis is one of the world's most serious health challenges. The World Health Organization says one-third of the world's population is infected - that's two billion people. The vast majority of them never get sick, but last year alone more than nine million did, and an estimated 1.7 million died from TB.

Treating tuberculosis has never been easy. Drugs must be taken for months, and too often patients stop taking the pills, which opens the way for resistant forms of the disease to develop. So the search is on for better ways to treat TB.

A PhD student at the University of Colorado has been exploring using existing drugs in a new form - a very fine powder that is inhaled, instead of a pill. J'aime Manion says most tuberculosis bacteria cluster in the lungs, so delivering drugs directly to the lungs can be more effective, faster, and require lower doses.

"Over and over again we see that when you treat with inhalation, you see a faster clearance of the bacteria," she said. "And this is so important because the treatment times for tuberculosis are from three to six months, with tons of antibiotics, with terrible side effects."

Manion has been working with inhalable particles that are about three microns in diameter - three one-thousandths of a millimeter across.

Creating the inhalant from an established drug that's manufactured in pill form isn't simply a matter of grinding it up into a fine powder. Manion says she and her team found that adding an amino acid called leucine gave the powdered medicine some useful properties, such as keeping the individual particles from sticking together.

"And when they're less sticky, they're able to blow apart and disperse better. And that's a really big, important thing for inhalable antibiotics because we want them to not go in as a clump, but to go in as individual particles and to make the most of their small size, so that they get where they're going and they get to the deepest, smallest parts of the lungs," Manion explained.

By inhaling the drug, the patient gets the medicine directly into the lungs, where most of the target tuberculosis bacteria are.

"The point of the inhalable antibiotics is, we can concentrate a dose in this area, and then maybe get more effect out of a lower dose because it's concentrated into a smaller area and it's hitting the affected site," she said. "And after it hits its target, it then is absorbed by the bloodstream and does further good in the body."

Inhaled drugs are already being used to treat other diseases, including asthma and cystic fibrosis. The challenges have mainly been in manufacturing the drug in such a way that the ultra-small particles actually get into the tiny passageways deep in the lungs. But scientists are overcoming some of those challenges.

At the same joint meeting of the International Pharmaceutical Federation and the American Association of Pharmaceutical Scientists where J'aime Manion presented her research, others were sharing their findings on inhalable drug delivery for conditions ranging from human papillomavirus to lung cancer.

Manion's work so far has focused on developing an inhalable form of tuberculosis antibiotics. Now that she has, she hopes other researchers will be able to continue the process with tests on laboratory animals.

You May Like

For Lebanon-based Refugees, Desperation Fuels Perilous Passage

In a war that has caused an estimated three million people to flee Syria, efforts to make perilous sea journey in search of asylum expected to increase More

South African Brewer Tackles Climate Change

Mega-brewer SAB Miller sent delegates to climate summit in Peru, says it is one of many private companies taking their own steps to fight climate change More

Indonesia Reports Increase in Citizens Joining Islamic State

Officials say more than 350 of its citizens are now in Syria or Iraq to fight with Islamic State - 50 more than last month More

This forum has been closed.
Comments
     
There are no comments in this forum. Be first and add one

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
Will Pakistan School Shooting Galvanize Pakistan Against Extremism?i
X
Ayesha Tanzeem
December 17, 2014 11:54 AM
The attack on a military school in Pakistan’s northwest city of Peshawar left 141 dead, including 132 children. Strong statements of condemnation poured in from across the world. The country announced three days of mourning, and the leadership, both political and military, promised retribution. VOA's Ayesha Tanzeem looks at how likely the Pakistani government is to clamp down on all extremist groups.
Video

Video Will Pakistan School Shooting Galvanize Pakistan Against Extremism?

The attack on a military school in Pakistan’s northwest city of Peshawar left 141 dead, including 132 children. Strong statements of condemnation poured in from across the world. The country announced three days of mourning, and the leadership, both political and military, promised retribution. VOA's Ayesha Tanzeem looks at how likely the Pakistani government is to clamp down on all extremist groups.
Video

Video ‘Anti-Islamization’ Marches Increase Tensions In Germany

Anti-immigrant rallies in Germany have been building in recent weeks, peaking Monday night in the city of Dresden where tens of thousands of people turned out to demonstrate against what they call the ‘Islamization’ of the West. Germany has offered asylum to more Syrian refugees than any other country, and this appears to have set off the protests. Henry Ridgwell reports from London.
Video

Video Aceh Rebuilt Decade After Tsunami, But Scars Remain

On December 26, 2004 there was an earthquake in the Indian Ocean so powerful it caused the Earth’s axis to wobble a few centimeters. Onshore on the island of Sumatra, the resulting tsunami was devastating. A decade later, VOA Correspondent Steve Herman reports from Banda Aceh, Indonesia, where although there is little remaining evidence of the physical devastation, the psychological scars among survivors remain.
Video

Video Refugees Living in Kenya Long for Peace in the Home Countries

Kenya is host to numerous refugees seeking safe haven from conflict. Immigrants from Somalia face challenges in their new lives in Kenya. Ahead of International Migrants Day (December 18) Lenny Ruvaga has more for VOA News from the Kenyan capital.
Video

Video Turkey's Authoritarianism Dismays Western Allies

The Turkish government has been defiant in the face of criticism at home and abroad for its raids targeting opposition media. The European Union on Monday expressed dismay after President Recep Tayyip Erdogan lashed out at Brussels for criticizing his government's action. Turkey's bid to be considered for EU membership has been on hold while critics accuse the NATO ally of increasingly authoritarian rule. Zlatica Hoke reports.
Video

Video US-China Year in Review: Hong Kong to Climate Change

The United States is pushing for a code of conduct to resolve territorial disputes in the South China Sea as it works to improve commercial ties with Beijing. VOA State Department correspondent Scott Stearns reports on a year of U.S. policy toward China from Hong Kong to climate change.
Video

Video Japanese Leader’s Election Win Raises Potential for Conflict with Neighbors

Japan’s Prime Minister Shinzo Abe and his allies easily won a two-thirds majority in parliament Sunday, even though the country has slipped into recession under his conservative policies. VOA’s Brian Padden reports from Seoul, that the prime minister’s victory will empower him to continue economic reforms but also pursue a nationalist agenda that will likely increase tensions with Japan’s neighbors.
Video

Video Nuba Mountain Families Hide in Caves to Escape Aerial Bombings

Despite ongoing peace talks between Sudan's government and the rebel Sudan People’s Liberation Movement-North, or SPLM-N, daily aerial attacks continue in South Kordofan province’s Nuba Mountains. Adam Bailes was there and reports for VOA that government forces are targeting civilian areas, rather than military positions, with their daily bombardments.

All About America

AppleAndroid