News / Health

New Vaccine Protects Monkeys Against Primate Version of HIV

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases testifies on Capitol Hill in Washington, November 2009. (file photo)
Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases testifies on Capitol Hill in Washington, November 2009. (file photo)
Jessica Berman

Researchers have developed a vaccine that protects Rhesus monkeys against SIV, the simian version of the human immunodeficiency virus that causes AIDS in humans. Scientists say the experiment could lead to improved treatments for AIDS, and speed development of an effective HIV vaccine.

Building on the results of a large experimental AIDS-vaccine trial in Thailand reported in 2009, researchers developed a two-stage vaccine made up of proteins from the simian immunodeficiency virus, or SIV, that protects a significant percentage of Rhesus macaques against the disease. SIV is a model for HIV because the human virus cannot infect monkeys.

Colonel Nelson Michael is a molecular virologist with the U.S Military HIV Research Program at the Walter Reed Army Institute, and senior author of the research.  

“We have now very good evidence, with new generation vaccines that we are seeing, the kinds of promising results in animals that would propel us to spend significant resources to test these vaccines in humans, which is what we are planning to do,” said Michael.

Investigators first gave their laboratory monkeys a genetically modified “primary” vaccine containing SIV proteins, followed six months later by a “boost” vaccine containing the same proteins. The vaccines were genetically modified to use different, harmless viruses to deliver the SIV proteins.

They also contained something left out of previous experimental vaccines that researchers believe makes the SIV more effective - portions of the virus’ outer envelope or shell.

Each week after the Rhesus monkeys received the vaccines, researchers tried to infect the monkeys with an aggressive strain of SIV.  

The vaccines reduced the animals' chances of becoming infected by 80 percent. Eventually, after repeated exposures, all of the animals became infected, but, according to Michael, they had far less virus in their blood than unvaccinated monkeys.

"If it is true in the human condition, that means individuals would have less circulating virus, they would be less sick, they would not need to go on therapy for a longer period of time but, probably most important, they would not transmit virus as easily to uninfected partners,” said Michael.

Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases, cautions that drugs developed through animal studies often can have different results in humans. But Fauci believes the study is an important step toward a human AIDS vaccine.

“The results were good and they gave us some significant insight into the kinds of responses you might want to elicit or induce in humans with a comparable vaccine,” said Fauci.

In fact, trials of a human version of the two-stage monkey vaccine are underway to test its safety and effectiveness. If all goes well, larger human trials of an HIV vaccine are planned in healthy adults in the US, eastern Africa, South Africa and Thailand, probably sometime next year.

An article by Michael and colleagues on the SIV vaccine is published in the journal Nature.

You May Like

Photogallery South Africa Bans Travelers From Ebola-stricken Countries

South Africans returning from affected West African countries will be thoroughly screened, required to fill out medical questionnaire, health minister says More

Multimedia UN Launches ‘Biggest Aid Operation in 30 Years’ in Iraq

Move aims to help thousands of Iraqi religious minorities who fled their homes as Kurdish, Iraqi government forces battle Sunni insurgents More

Video African Media Tries to Educate Public About Ebola

IT specialists, together with radio and TV reporters, are battling misinformation and prejudice about disease More

This forum has been closed.
Comments
     
There are no comments in this forum. Be first and add one

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
Gaza Conflict, Hamas Popularity Challenge Abbasi
X
Scott Stearns
August 21, 2014 9:20 PM
The Palestinian unity government of Mahmoud Abbas has failed to convince Hamas to agree to Egyptian-negotiated terms with Israel on a Gaza cease-fire. VOA State Department Correspondent Scott Stearns reports on what the Gaza conflict means for President Abbas, with whom U.S. officials have worked for years on a two-state solution to the Israeli-Palestinian conflict.
Video

Video Gaza Conflict, Hamas Popularity Challenge Abbas

The Palestinian unity government of Mahmoud Abbas has failed to convince Hamas to agree to Egyptian-negotiated terms with Israel on a Gaza cease-fire. VOA State Department Correspondent Scott Stearns reports on what the Gaza conflict means for President Abbas, with whom U.S. officials have worked for years on a two-state solution to the Israeli-Palestinian conflict.
Video

Video Nigeria's 'Nollywood' Movie Industry Rolls in High Gear

Twenty years after its birth in a video shop in Lagos, Nigeria's "Nollywood" is one of the most prolific film industries on earth. Despite low budgets and whirlwind production schedules, Nigerian films are wildly popular in Africa and industry professionals say they hope, in the future, their films will be as great in quality as they are in quantity. Heather Murdock has more for VOA from Lagos.
Video

Video UN Launches 'Biggest Aid Operation in 30 Years' in Iraq

The United Nations has launched what it describes as one of the biggest aid operations in 30 years in northern Iraq, as hundreds of thousands of refugees flee the extremist Sunni militant group calling itself the Islamic State. As Kurdish and Iraqi forces battle the Sunni insurgents, the fighting has forced more people to flee their homes. Kurdish authorities say the international community must act now to avert a humanitarian catastrophe. Henry Ridgwell reports for VOA from London.
Video

Video Cambodian American Hip Hop Artist Sings of Personal Struggles

A growing underground movement of Cambodian American hip hop artists is rapping about the struggles of living in urban America. Most, if not all of them, are refugees or children of refugees who came to the United States from Cambodia to escape the Khmer Rouge genocide of the 1970s. Through their music, the artists hope to give voice to immigrants who have been struggling quietly for years. Elizabeth Lee reports from Long Beach, California.
Video

Video African Media Tries to Educate Public About Ebola

While the Ebola epidemic continues to claim lives in West Africa, information technology specialists, together with radio and TV reporters, are battling misinformation and prejudice about the disease - using social media to educate the public about the deadly virus. VOA’s George Putic has more.
Video

Video Ferguson Calls for Justice as Anger, Violence Grips Community

Violence, anger and frustration continue to grip the small St. Louis suburb of Ferguson, Missouri. Protests broke out after a white police officer fatally shot an unarmed black teenager on August 9. The case has sparked outrage around the nation and prompted the White House to send U.S. Attorney Eric Holder to the small community of just over 20,000 people. VOA’s Mary Alice Salinas has more from Ferguson.
Video

Video Beheading Of US Journalist Breeds Outrage

U.S. and British authorities have launched an investigation into an Islamic State video showing the beheading of kidnapped American journalist James Foley by a militant with a British accent. The extremist group, which posted the video on the Internet Tuesday, said the murder was revenge for U.S. airstrikes on militant positions in Iraq - and has threatened to execute another American journalist it is holding. Henry Ridgwell has more from London.
Video

Video Family Robots - The Next Big Thing?

Robots that can help us with daily chores like cooking and cleaning are a long way off, but automatons that serve as family companions may be much closer. Researchers in the United States, France, Japan and other countries are racing to build robots that can entertain and perform some simpler tasks for us. VOA’s George Putic reports.
Video

Video In Ukraine, Fear and Distrust Remain Where Fighting has Stopped

As the Ukrainian military reclaims control of eastern cities from pro-Russian separatists, residents are getting a chance to rebuild their lives. VOA's Gabe Joselow reports from the town of Kramatorsk in Donetsk province, where a sense of fear is still in the air, and distrust of the government in Kyiv still runs deep.
Video

Video Five Patients Given Experimental Ebola Drug Said to Be Improving

The World Health Organization has approved the use of experimental treatments for Ebola patients in West Africa. The Ebola outbreak there is unprecedented, the disease deadly. The number of people who have died from Ebola has surpassed 1,200. VOA's Carol Pearson reports on the ethical considerations of allowing experimental drugs to be used.
Video

Video China Targets Overseas Assets of Corrupt Officials

As China presses forward with its anti-graft effort, authorities are targeting corrupt officials who have sent family members and assets overseas. The efforts have stirred up a debate at home on exactly how many officials take that route and how likely it is they will be caught. Rebecca Valli has this report.
Video

Video Leading The Fight Against Islamic State, Kurds Question Iraqi Future

Western countries including the United States have begun arming the Kurdish Peshmerga forces in northern Iraq to aid their battle against extremist Sunni militants from the Islamic State. But there are concerns that a heavily-armed Kurdistan Regional Government, or KRG, might seek to declare independence and cause the break-up of the Iraqi state. As Henry Ridgwell reports from London, the KRG says it will only seek greater autonomy from Baghdad.
Video

Video In Rural Kenya, Pressure Builds Against Female Circumcision

In some Kenyan communities, female genital mutilation remains a rite of passage. But activists are pushing back, with education for girls and with threats of punishment those who perform the circumcision. Mohammed Yusuf looks at the practice in the rural eastern community of Tharaka-Nithi.

AppleAndroid