News / Health

    Researchers Develop Promising Breast Cancer Vaccine

    Researchers Develop Promising Breast Cancer Vaccine
    Researchers Develop Promising Breast Cancer Vaccine
    Jessica Berman

    Scientists have made a discovery they say could lead to a vaccine to prevent and cure breast cancer, a common and deadly disease that afflicts millions of women around the world.  

    The experimental vaccine developed by researchers at Cleveland Clinic's Lerner Institute in Ohio was 100 percent effective in preventing breast cancer in a group of mice specially bred to develop the disease.  The vaccine, which has been in the works for the past eight years,  also stopped the growth of existing tumors.

    Breast cancer is the second most common cancer in women worldwide, and there are approximately a half million new cases reported each year.  The disease is notoriously hard to cure. It often recurs within 10 years, despite treatments thought to be effective at the time of diagnosis.

    Lead researcher Vincent Tuohy says the experimental vaccine works by stimulating the immune system to protect the body against the development of breast cancer.  Until now, the major hurdle for researchers working on cancer vaccines has been finding ways to avoid setting off auto-immune responses in cancer patients.  Autoimmunity occurs when the body's immune system mistakenly attacks healthy tissue or organ systems.

    The resulting inflammation can trigger an even more aggressive form of breast cancer.   But vaccine researchers have found a way to target proteins that are only present in breast tumors but not in healthy breast tissue, according to Tuohy.

    Tuohy says the vaccine kept the specially-bred, breast cancer-prone lab mice completely tumor-free.

    "We found the first way of creating a self-vaccine that can be used prophylactically, in a preventive manner, to protect us against a disease before we get it just like polio and measles," said Vincent Tuohy.

    Experts say a woman has a 12 percent risk of being diagnosed with breast cancer over her lifetime.  But according to the US National Cancer Institute, women who have inherited two abnormal genes, called BRCA (BROCK-AH) 1 and BRCA (BROCK-AH) 2, have a much higher, 60 percent risk of developing breast cancer by age 90.

    Becca Martello was diagnosed with advanced breast cancer at age 39.  She underwent surgery, radiation, chemotherapy, and had her uterus removed to prevent the cancer from recurring.

    Breast cancer runs in Martello's family and she's thrilled at the prospect of a vaccine to prevent the deadly disease.

    "I can't really believe it yet," said Becca Martello. "I'm just so thrilled, [I have] goose bumps; just amazing."

    Meanwhile, the researchers at Cleveland Clinic plan to ask US regulators for permission to begin human safety trials of the vaccine within the next year.  The breast cancer vaccine would be targeted at women age 40 and older.

    Lead researcher Vincent Touhy says the breast cancer vaccine project was inspired by the success childhood immunization programs have had in preventing infectious diseases in young people. But no such medically effective safeguards have been available for people middle-aged  and older:

    "And yet they confront these horrific diseases like breast cancer and prostate cancer and colon cancer and so forth and I thought this is the giant hole." he said. "We don't have a similar preventive vaccine program for adult diseases."

    Tuohy and his colleagues describe their research in an article this week in the journal Nature Medicine.

    You May Like

    Wife of IS Leader Charged in Death of US Hostage

    Suspect allegedly admitted to being responsible for American aid worker Kayla Mueller, who officials say was sexually abused and ‘owned’ by one IS member

    Year of the Monkey Could Prove Economic Balancing Act for China

    China is up against a tricky situation on the financial front, facing the need to fight capital flight while also stopping a further slide of foreign currency reserves

    Runners Attempt 26-mile South Pole Marathon in Sub-Zero Temperatures

    How alluring is running 26.2 miles at 10,000 feet when it’s minus 31 Celsius out?

    This forum has been closed.
    Comments
         
    There are no comments in this forum. Be first and add one

    Featured Videos

    Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
    'No Means No' Program Targets Sexual Violence in Kenyai
    X
    February 08, 2016 4:30 PM
    The organizers of an initiative to reduce and stop rape in the informal settlements around Kenya's capital say their program is having marked success. Girls are taking self-defense classes while the boys are learning how to protect the girls and respect them. Lenny Ruvaga reports from Nairobi.
    Video

    Video 'No Means No' Program Targets Sexual Violence in Kenya

    The organizers of an initiative to reduce and stop rape in the informal settlements around Kenya's capital say their program is having marked success. Girls are taking self-defense classes while the boys are learning how to protect the girls and respect them. Lenny Ruvaga reports from Nairobi.
    Video

    Video New Hampshire Voters Are Independent, Mindful of History

    Once every four years, the northeastern state of New Hampshire becomes the center of the U.S. political universe with its first-in-the-nation presidential primary. What's unusual about New Hampshire is how seriously the voters take their role and the responsibility of being among the first to weigh in on the candidates.
    Video

    Video Chocolate Lovers Get a Sweet History Lesson

    Observed in many countries around the world, Valentine’s Day is sometimes celebrated with chocolate festivals. But at a festival near Washington, the visitors experience a bit more than a sugar rush. They go on a sweet journey through history. VOA’s June Soh takes us to the festival.
    Video

    Video 'Smart' Bandages Could Heal Wounds More Quickly

    Simple bandages are usually seen as the first line of attack in healing small to moderate wounds and burns. But scientists say new synthetic materials with embedded microsensors could turn bandages into a much more valuable tool for emergency physicians. VOA’s George Putic reports.
    Video

    Video Bhutanese Refugees in New Hampshire Closely Watching Primary Election

    They fled their country and lived in refugee camps in neighboring Nepal for decades before being resettled in the northeastern U.S. state of New Hampshire -- now the focus of the U.S. presidential contest. VOA correspondent Aru Pande spoke with members of the Bhutanese community, including new American citizens, about the campaign and the strong anti-immigrant rhetoric of some of the candidates.
    Video

    Video Researchers Use 3-D Printer to Produce Transplantable Body Parts

    Human organ transplants have become fairly common around the world in the past few decades. Researchers at various universities are coordinating their efforts to find solutions -- including teams at the University of Pennsylvania and Rice University in Houston that are experimenting with a 3-D printer -- to make blood vessels and other structures for implant. As VOA’s Greg Flakus reports from Houston, they are also using these artificial body parts to seek ways of defeating cancerous tumors.
    Video

    Video Helping the Blind 'See' Great Art

    There are 285 million blind and visually impaired people in the world who are unable to enjoy visual art at a museum. One New York photographer is trying to fix this situation by making tangible copies of the world’s masterpieces. VOA correspondent Victoria Kupchinetsky was there as visually impaired people got a feel for great art. Joy Wagner narrates her report.
    Video

    Video Sanders, Clinton Battle for Young Democratic Vote

    Despite a narrow loss to former Secretary of State Hillary Clinton in last week's Iowa Democratic caucuses, Vermont Senator Bernie Sanders secured more than 80 percent of the vote among those between the ages of 18 and 29. VOA correspondent Aru Pande talks to Democrats in New Hampshire about who they are leaning towards and why in this week's primary.
    Video

    Video German Artists to Memorialize Refugees With Life Jacket Exhibit

    Sold in every kind of shop in some Turkish port towns, life jackets have become a symbol of the refugee crisis that brought a million people to Europe in 2015.  On the shores of Lesbos, Greece, German artists collect discarded life jackets as they prepare an art installation they plan to display in Germany.  For VOA, Hamada Elrasam has this report from Lesbos, Greece.
    Video

    Video E-readers Help Ease Africa's Book Shortage

    Millions of people in Africa can't read, and there's a chronic shortage of books. A non-profit organization called Worldreader is trying to help change all that one e-reader at a time. VOA’s Deborah Block tells us about a girls' school in Nairobi, Kenya where Worldreader is making a difference.
    Video

    Video Genius Lets World Share Its Knowledge

    Inspired by crowdsourcing companies like Wikipedia, Genius allows anyone to edit anything on the web, using its web annotation tool
    Video

    Video In Philippines, Mixed Feelings About Greater US Military Presence

    In the Philippines, some who will be directly affected by a recent Supreme Court decision clearing the way for more United States troop visits are having mixed reactions.  The increased rotations come at a time when the Philippines is trying to build up its military in the face of growing maritime assertiveness from China.  From Bahile, Palawan on the coast of the South China Sea, Simone Orendain has this story.
    Video

    Video Microcephaly's Connection to Zika: Guilty Until Proven Innocent

    The Zika virus rarely causes problems for the people who get it, but it seems to be having a devastating impact on babies whose mothers are infected with Zika. VOA's Carol Pearson has more.
    Video

    Video Stunning Artworks Attract Record Crowds, Thanks to Social Media

    A new exhibit at the oldest art museum in America is shattering attendance records. Thousands of visitors are lining up to see nine giant works of art that have gotten a much-deserved shot of viral marketing. The 150-year-old Smithsonian American Art Museum has never had a response quite like this. VOA's Julie Taboh reports.