News / USA

Scientists Identify Cause of Age-Related Memory Loss

A researcher holds a human brain in a laboratory (File photo).
A researcher holds a human brain in a laboratory (File photo).
Jessica Berman
Scientists have identified a protein that appears to be a major cause of age-related memory loss.  The discovery could lead to effective treatments for a problem that plagues many elderly people.

In 2010, an estimated 36 million people worldwide ages 65 and older were living with some form of dementia.  But not all of those with this form of memory loss have Alzheimer’s disease, which also affects judgment and thinking, making it hard to work or take part in day-to-day life.

Now, researchers at Columbia University Medical Center in New York have identified a protein in a region of the brain called the hippocampus that is deficient in older people with memory loss, but not in those suffering from Alzheimer’s.

Eric Kandel, a Nobel Prize Laureate and expert on memory storage, led the study implicating the protein, called RbAp48, as a cause of memory lapses in older individuals. Researchers demonstrated RbAp48’s role in memory in laboratory animals.

“What happens if you take a young mouse and you knock out the gene for that protein in the young mouse?  That mouse shows at a very young age, age-related memory loss," Kandel said. "If you take an old mouse and restore the protein, [you] reverse the age-related memory loss.”

Molecular studies of the brains of people with age-related memory loss reveal a deficiency of the protein in the dentate gyrus, one of a number of structures in the hippocampus.

That defect is not seen in the brains of a mouse model of Alzheimer's disease.  In fact, Kandel said it was not possible to give Alzheimer’s to mice by manipulating their levels of RbAp48.    

Because it may turn out that age-related memory loss is a condition separate and apart from Alzheimer's disease, Kandel said the finding could have important implications for people suffering from normal memory loss.  “I think that we might be able to develop a therapeutic approach to age-related memory loss.  We now have the possibility of developing better diagnostic ways of evaluating using imaging.  And we might be fortunate in getting something that works effectively,” he said.

An article describing the role of the protein RbAp48 in age-related memory loss is published in the journal Science Translational Medicine.

You May Like

French Refugee Drama Wins Cannes Top Prize

Dheepan is about a group of Sri Lankan refugees who pretend to be a family in order to flee their war-torn country for a housing project in France More

Photogallery Crisis in Macedonia Requires Meaningful and Swift Measures

The international community has called on Macedonian leadership to take concrete measures in support of democracy in order to exit the crisis More

Activists: IS Executes 217 Civilians, Soldiers Near Palmyra

British-based Syrian Observatory for Human Rights on Sunday said the victims include nurses, women, children and Syrian government fighters More

This forum has been closed.
Comments
     
There are no comments in this forum. Be first and add one

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
Turkey's Main Opposition Party Hopes for Election Breakthroughi
X
May 22, 2015 10:23 AM
Turkey’s main opposition Republican People’s Party has sought an image change ahead of the June 7 general election. The move comes after suffering successive defeats at the hands of the Islamist-rooted AK Party, which has portrayed it as hostile to religion. Dorian Jones reports from the western city of Izmir.
Video

Video Turkey's Main Opposition Party Hopes for Election Breakthrough

Turkey’s main opposition Republican People’s Party has sought an image change ahead of the June 7 general election. The move comes after suffering successive defeats at the hands of the Islamist-rooted AK Party, which has portrayed it as hostile to religion. Dorian Jones reports from the western city of Izmir.
Video

Video Europe Follows US Lead in Tackling ‘Conflict Minerals’

Metals mined from conflict zones in places like the Democratic Republic of Congo are often sold by warlords to buy weapons. This week European lawmakers voted to force manufacturers to prove that their supply chains are not inadvertently fueling conflicts and human rights abuses. Henry Ridgwell reports from London.
Video

Video Class Tackles Questions of Race, Discrimination

Unrest in some U.S. cities is more than just a trending news item at Ladue Middle School in St. Louis, Missouri. As VOA’s Kane Farabaugh reports, it’s a focus of a multicultural studies class engaging students in wide-ranging discussions about racial tensions and police aggression.
Video

Video Mind-Controlled Prosthetics Are Getting Closer

Scientists and engineers are making substantial advances towards the ultimate goal in prosthetics – creation of limbs that can be controlled by the wearer’s mind. Thanks to sophisticated sensors capable of picking up the brain’s signals, an amputee in Iceland is literally bringing us one step closer to that goal. VOA’s George Putic reports.
Video

Video Afghan Economy Sinks As Foreign Troops Depart

As international troops prepare to leave Afghanistan, and many foreign aid groups follow, Afghans are grappling with how the exodus will affect the country's fragile economy. Ayesha Tanzeem reports from the Afghan capital, Kabul.
Video

Video Poverty, Ignorance Force Underage Girls Into Marriage

The recent marriage of a 17-year old Chechen girl to a local police chief who was 30 years older and already had a wife caused an outcry in Russia and beyond. The bride was reportedly forced to marry and her parents were intimidated into giving their consent. The union spotlighted yet again the plight of many underage girls in developing countries. Zlatica Hoke reports poverty, ignorance and fear are behind the practice, especially in Asia and Africa.
Video

Video South Korea Marks Gwangju Uprising Anniversary

South Korea this week marked the 35th anniversary of a protest that turned deadly. The Gwangju Uprising is credited with starting the country’s democratic revolution after it was violently quelled by South Korea’s former military rulers. But as Jason Strother reports, some observers worry that democracy has recently been eroded.
Video

Video California’s Water System Not Created To Handle Current Drought

The drought in California is moving into its fourth year. While the state's governor is mandating a reduction in urban water use, most of the water used in California is for agriculture. But both city dwellers and farmers are feeling the impact of the drought. Some experts say the state’s water system was not created to handle long periods of drought. Elizabeth Lee reports from Ventura County, an agricultural region just northwest of Los Angeles.
Video

Video How to Clone a Mammoth: The Science of De-Extinction

An international team of scientists has sequenced the complete genome of the woolly mammoth. Led by the Swedish Museum of Natural History in Stockholm, the work opens the door to recreate the huge herbivore, which last roamed the Earth 4,000 years ago. VOA’s Rosanne Skirble considers the science of de-extinction and its place on the planet
Video

Video Blind Boy Defines His Life with Music

Cole Moran was born blind. He also has cognitive delays and other birth defects. He has to learn everything by ear. Nevertheless, the 12-year-old has had an insatiable love for music since he was born. VOA’s June Soh introduces us to the young phenomenal harmonica player.

VOA Blogs