Representatives from the Syrian government and the Western-backed opposition will hold their first-ever joint meeting aimed at resolving nearly three years of civil war.
United Nations peace mediator Lakhdar Brahimi says both sides will sit down "in the same room" on Saturday in Geneva. Brahimi has spent the last two days in Switzerland shuttling between the two camps to encourage direct peace negotiations.
Syria's government had threatened to walk out of peace talks with the opposition if the two sides do not begin what it called "serious sessions" by Saturday. The opposition has said it will not negotiate directly with the Syrian government unless it agrees to discuss the departure of President Bashar al-Assad.
Damascus has refused, accusing the rebels of supporting terrorism.
Earlier, U.S. Secretary of State John Kerry ramped up criticism of Syrian President Bashar al-Assad, calling him a "one-man super-magnet for terrorism" that "will never earn back legitimacy" to bring his country back together.
Speaking at the World Economic Forum on Friday in Davos, Switzerland, Kerry said that if the goal is to have peace in Syria, Mr. Assad needed to step down because the opposition would never stop fighting while he is in power. He said the embattled president has brought "havoc" on Syrians, unleashing bombs and "gassing his own people in the dead of night."
Kerry added the world has seen how forceful diplomacy can achieve goals in Syria, as a man who once refused to admit he had chemical weapons has now removed them from his arsenal.
The official goal of the so-called Geneva 2 talks is to form a Syrian transition government, though analysts say the chances of achieving this goal are slim. Instead, more modest achievements, such as allowing humanitarian aid to civilians, are expected.
The Syrian conflict began in March 2011 as peaceful protests before spiraling into a civil war that the U.N. says has killed well over 100,000 people and forced nearly 9 million from their homes.