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New Test Could Speed Tuberculosis Results

24 March 2009

This is the VOA Special English Health Report.

Tuberculosis killed one million three hundred thousand people around the world in two thousand seven. In addition, almost half a million people who were infected with tuberculosis and with H.I.V. also died. Those were listed as H.I.V. deaths.

An estimated one-third of all people are infected with tuberculosis. But the body's natural defenses are usually strong enough to prevent an active case. Even so, the bacteria remain in the body. If the immune system weakens at any point, they begin to spread and then attack.

A doctor at a clinic in South Africa looks at a patient's X-ray as part of a TB exam
A doctor at a clinic in South Africa looks at a patient's X-ray as part of a TB exam
The bacteria that cause TB usually settle in the lungs. They spread through the air when the person coughs or sneezes or even sings and talks.

One of the most important things is to identify cases quickly -- especially drug-resistant cases, which are increasing. The patients need to be kept away from other people and begin treatment as soon as possible.

Multidrug resistant tuberculosis, or MDR-TB, will not get better with antibiotics normally used for tuberculosis. So doctors must use stronger, "second line" drugs when the first ones fail. Extensively drug-resistant tuberculosis, or XDR-TB, will not respond to any of those drugs but might still be treatable.

Now, researchers say they have found a much faster way to identify drug-resistant TB. The study's lead author is Graham Hatfull at the University of Pittsburgh in Pennsylvania. He says current tests can sometimes take weeks in rural and poor areas of the world. By that time, the patient may already be dead.

The scientists used viruses called bacteriophages to speed the process. These viruses attack bacteria. The researchers injected them with a gene that produces a green glow of light. They also injected some with first line antibiotics and others with second line drugs.

Then they combined the bacteriophages with TB bacteria. If the bacteria glow, it means they are drug resistant. The researchers say a clinic worker could identify the glow with equipment available in many clinics. Test results would not have to wait for the bacteria to grow in a laboratory far away.

For now, the test itself needs more testing. But Professor Hatfull is hopeful this will take months and not years.

Researchers from the Albert Einstein College of Medicine in New York also took part in the study, financed by the Howard Hughes Medical Institute. The findings appear in the journal PLoS ONE, published by the Public Library of Science.

And that's the VOA Special English Health Report, written by Caty Weaver. I'm Steve Ember.



Comments:

1. Diagnostics

If we can diagnose the MDRTB quickly in the country like India which ranks very high in TB cases, we may hope less spread of disease
Submitted by: Dr. Anupama Das (India)
04-10-2009 - 08:30:39

2.

this article is very good
Submitted by: mike (turkey)
04-05-2009 - 12:57:30

3. TB in Poor countries

This report is very important and useful for medical student like me. I request afghan goverment to help the poor people in afghanistan as well as preventing the terrible diseas of T B.
Submitted by: Naeem haqmall (Afghanistan)
04-01-2009 - 11:48:32

4. Good News

This piece of information is very useful to be shared to my friends who are working closely with TB patients. This news also gives hope to those who are living with TB.
Submitted by: Chan Sopheak (Cambodia)
04-01-2009 - 10:25:37

5. New test on TB

It is a great progress
Submitted by: Sufi Mudi (Ethiopia)
03-30-2009 - 12:37:59

6. a good news

I do know how horrible this disease is as I'm studying medicine in a developing country like Vietnam.Tuberculosis even gets worse in HIV patients or in the cases that the bacterium becomes drug-resistant.I do hope that a new test like this one will be soon applied in Vietnam to help stop the spread of this disease.
Submitted by: do quang anh (Vietnam)
03-27-2009 - 17:02:39

7. Tuberculosis test result

This report is very important for for donors continuing to support food assistance to the TB patients that most of them are from the poorest family and they are living in the rural areas in cambodia
Submitted by: Chea Dala (Cambodia)
03-27-2009 - 10:58:24

8. study

From the report I not only study English but also know Tuberculosis is terrible.
Submitted by: Yong Bei (China)
03-26-2009 - 12:48:07

9. very helpful

this article is very good,we need.and hope test TB is quickly and cheaply.
Submitted by: kingkang (china)
03-25-2009 - 02:18:48

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Report in PLoS ONE