The Los Angeles County coroner says the death of pop star Michael Jackson was homicide primarily caused by two drugs: propofol, a powerful anesthetic, and Lorazepam, a sedative. 

Jackson's doctor, Conrad Murray, told investigators that he gave the pop star a series of drugs starting with Valium and then Lorazepam, followed by a sedative - all so Jackson  would be able to sleep.  The drugs didn't work.

Early the next morning, Dr. Murray gave Jackson propofol intravenously. The drug is designed for hospital use only.
Dr. Rick Levy is vice chief of anesthesiology and pain medicine at Children's National Medical Center in Washington. He says propofol is a drug of choice for anesthesiologists.

"Anesthesiologists generally do like it around the world because it's designed for faster onset, going off to sleep, and faster offset in terms of waking up, so for outpatient, ambulatory surgery, that really was the niche market it was designed for," he explained.

Propofol puts patients to sleep in seconds. The drug is also used with other anesthetics.

"Because it's not a controlled substance yet, it's much easier to access within the operating room," he added.

And because propofol is not a controlled substance, other doctors can get it, even if they are not trained in using it, and that's where they can get in trouble.

Propofol can cause patients to stop breathing, but in the operating room, anesthesiologists are equipped to resuscitate them. Propofol can also lead to trouble with blood pressure and heart function.

"Much of anesthesiology and intensive care is being able to manage those patients and those responses that are outside what the expected is so that you still keep the patient safe," he explained.

Propofol is not designed to be a sleep aid.

Jackson's personal physician at the time, Dr. Conrad Murray, as well as other doctors who were caring for the singer, are the focus of the criminal investigation.