Three trains have collided at a station in southern Pakistan Wednesday, killing at least 127 people and injuring hundreds more.

The pre-dawn collision at the Ghotki railway station in southern province of Sindh is being described as the deadliest in a decade.

Pakistani authorities and eyewitnesses say an express train coming from Karachi crashed into another that was stopped at the station for repairs. A third train, coming the other way, then ploughed into the wreckage.

Police and rescue workers are searching through the twisted wreckage for more bodies, fearing the death toll from the disaster could rise.

Pakistan Railway's Director of Operations, Nasir Zaidi, says the collision appears to be human error. "The Karachi Express driver perhaps did not observe the rule or the signals were wrong for him ," he said.

The government has ordered an investigation into the cause of the accident.

Witnesses say the injured were being taken in ambulances and cars to area hospitals while special trains are being sent to the site to take stranded survivors to their destinations.

A major train crash at the same railway station in 1991 had killed more than a hundred people. Train accidents in Pakistan are often blamed on faulty equipment or human error.