Afghan police and U.S. troops in the eastern city of Jalalabad have opened fire to break up rioting by students angry at alleged desecration of the Koran at the U.S. jail in Guantanamo Bay, Cuba.

Local health officials say at least three people were killed and some 60 others wounded -- some seriously.

Demonstrators chanting "Death to America" marched through streets Wednesday, smashing cars, damaging shops and throwing stones at U.S. troops.

Protests erupted after Newsweek magazine reported that interrogators at Guantanamo placed copies of the Muslim holy book on toilets to rattle terrorist suspects.

The United States has condemned the alleged desecration of the Koran, saying such activity would be reprehensible and contrary to U.S. policy.

The U.S. military says any kind of violation of the religious rights of detainees will be treated very seriously.

Some information for this report provided by AP, AFP and Reuters.