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Cellular Delivery System Research Wins Nobel Prize

James Rothman and Randy Schekman, of the US, and German-born researcher Thomas Suedhof are projected on a screen, in Stockholm, Sweden after they were announced as the winners of the 2013 Nobel Prize in medicine, Oct. 7, 2013.
James Rothman and Randy Schekman, of the US, and German-born researcher Thomas Suedhof are projected on a screen, in Stockholm, Sweden after they were announced as the winners of the 2013 Nobel Prize in medicine, Oct. 7, 2013.
Three researchers studying how cells transport chemicals within and between cells have won this year’s Nobel Prize in Physiology or Medicine.

2013 Nobel Prize in Physiology, Medicine

Awarded to three scientists for solving the mystery of how the cell organizes its transport system

  • James Rothman: Professor and Chairman in the Department of Cell Biology at Yale University
  • Randy Schekman: Professor in the Department of Molecular and Cell Biology at the University of California at Berkeley
  • Thomas Sudhof: Professor of Molecular and Cellular Physiology at Stanford University
To explain what the researchers discovered, Harvard University cell biologist Tom Kirchhausen says it helps to think of each cell in the body as a tiny city.

“You have people that are moving from one place to the other to do whatever function they do,” he said. “You move from place to place in carriers or containers,” like buses, trucks or trains, he says.

In this analogy, the people are the proteins, hormones and other chemicals that do the work and carry messages in our bodies.

Insulin, produced in the pancreas but used throughout the body, is one example. Or neurotransmitters that carry brain signals from one neuron to another.

The transport system - the cell’s tiny buses, trucks or trains - has to get them from one part of the cell to another, or to the outside of the cell. If the system breaks down, the results are diseases like diabetes or neurodegenerative disorders.

Yeast to people

The process is so fundamental to life that evolution has not changed it much from yeast to people.

Randy Schekman at the University of California at Berkeley discovered in yeast the genetic blueprints for the proteins that make up the cellular delivery system.

Later, says neuroscientist Erik Jorgensen at the University of Utah, researchers found out “that the proteins involved in this process that allow us to think, that allow nerve cells to communicate with one another, are precisely the same ones that were found in yeast.”

But Schekman’s work was just a piece of the puzzle. James Rothman at Yale University discovered how each little cellular bus delivers its passengers to the right station.

“From Schekman’s work we had a list of the players,” Jorgensen said. “What Rothman showed us was who was interacting with whom.”

And the third prize winner, Thomas Südhof, discovered how in nerve cells those little buses release their passengers quickly and precisely in response to a signal.

Research at risk

At a press conference, Rothman noted that his good mood was due to his neurons secreting endorphins, one class of neurotransmitters delivered through the mechanism he and his colleagues had discovered.

Rothman said he was lucky to get his start at a time when a young scientist could take risks to pursue an idea.

“I’d like to think that that kind of support existed today, but I think there’s less of it," he said. "And it’s actually becoming a pressing national issue, if not an international issue.”

He said U.S. funding for scientific research has declined in recent years, threatening American leadership in science and technology.

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