News / Health

Blood of Young Mice Reverses Signs of Aging in Older Ones

A protein found in young mice, which is also found in humans, resulted in the formation of new blood vessels and improved blood flow in older mice.
A protein found in young mice, which is also found in humans, resulted in the formation of new blood vessels and improved blood flow in older mice.
Jessica Berman
Two new studies show that young blood reverses signs of aging in old mice, but that doesn't mean scientists have finally found the elusive fountain of youth.

However, the discovery could one day help people lead healthier lives.

In two papers published in Science, Harvard University researchers in Boston describe how the protein GDF11, found in higher levels in the blood of young mice, improved the brain and muscle function of older mice.

GDF11 appears to work by stimulating the development of new blood vessels. The protein is also present in humans.

In one experiment, researchers increased the levels of GDF11 in aging mice by surgically connecting the circulatory systems of young mice to the old rodents.  

Blood containing higher levels of GDF11 flowed through the veins of both animals. In another experiment, they injected the protein into elderly mice. Scientists saw the greatest improvement in function in mice that shared the same blood supply.

Investigators saw the formation of new blood vessels and improved blood flow in older mice, which they say reversed signs of aging in every tissue they looked at.

Researcher Lee Rubin, professor of stem cell and regenerative biology at Harvard's Stem Cell Institute, and his team investigated the effect of GDF11 on brain tissue.  

"So, this simple surgery, infusing an old mouse with young blood, actually produced some structural changes in the old brain, making the old brain, in essence, more like [a] young brain," he said. "And some people have used the phrase 'rejuvenating the old brain.'  And similar things were observed in other tissues."

Rubin colleague Amy Wagers observed that GDF11 repaired DNA damage associated with aging.  In prior experiments with the protein, Wagers and colleagues noted the enlarged, weakened hearts of older mice returned to a more youthful size and beat more efficiently.  So-called diastolic heart failure, a fatal condition, is common in aging humans and this research raises hopes the disease may be reversible.

Similarly, Rubin says GDF11 possibly could improve memories for Alzheimer's disease patients or movement for Parkinson's victims. But he says the protein is not a "fountain of youth," and the aim of research is not increasing, but improving life span.

"In other words, even if you did not live more years, at least you could remain healthier for the number of years you do live," he said. "And I think again, what we've shown is functional improvement in ... various different tissues in mice."

In an article in Nature, published simultaneously, researchers at Stanford University in California report blood from young mice improved neural circuits, enhancing learning and memory in older rodents.

Researchers in Massachusetts and California have teamed with biotechnology firms to see whether the findings can be translated to humans. Harvard University's Lee Rubin predicts clinical trials could begin in three to five years.

You May Like

China May Be Biggest Winner From Ukraine Crisis

Missile sales, oil and gas shipments are among many areas that may drive Beijing and Moscow closer together in coming years More

Obama Faces a Chaotic World and the Limits of Power

Current foreign policy issues bring into focus challenges for US policymakers who are mindful of Americans' waning appetite for overseas military engagements More

SADC Meeting Lesotho Officials to Resolve Stalemate

Official says regional bloc has been engaged with leaders in Lesotho to resolve political disagreement that led to coup attempt More

This forum has been closed.
Comment Sorting
Comments
     
by: sharon from: Georgia
May 30, 2014 4:05 PM
OMG find me 1000 young mice.


by: David from: Kent
May 09, 2014 10:31 PM
O god, this sounds like the premise for a sci-fi horror story.


by: Gregg Williamson from: Oregon USA
May 05, 2014 3:19 PM
Ok, so sharing the blood helped the older mice, but what did
it do to the younger mice?

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
West Africa Ebola Vaccine Trials Possible by Early 2015i
X
Carol Pearson
August 30, 2014 7:14 PM
A U.S. health agency is speeding up clinical trials of a possible vaccine against the deadly Ebola virus that so far has killed more than 1,500 people in West Africa. If successful, the next step would be a larger trial in countries where the outbreak is occurring. VOA's Carol Pearson has more.
Video

Video West Africa Ebola Vaccine Trials Possible by Early 2015

A U.S. health agency is speeding up clinical trials of a possible vaccine against the deadly Ebola virus that so far has killed more than 1,500 people in West Africa. If successful, the next step would be a larger trial in countries where the outbreak is occurring. VOA's Carol Pearson has more.
Video

Video Survivors Commemorate 70th Anniversary of Nazi Liquidation of Jewish Ghetto

When the German Nazi army occupied the Polish city of Lodz in 1939, it marked the beginning of a long nightmare for the Jewish community that once made up one third of the population. Roughly 200,000 people were forced into the Lodz Ghetto. Less than 7,000 survived. As VOA’s Kane Farabaugh reports, some survivors gathered at the Union League Club in Chicago on the 70th anniversary of the liquidation of the Lodz Ghetto to remember those who suffered at the hands of the Nazi regime.
Video

Video Cost to Raise Child in US Continues to Rise

The cost of raising a child in the United States continues to rise. In its latest annual report, the U.S. Department of Agriculture says middle income families with a child born in 2013 can expect to spend more than $240,000 before that child turns 18. And sending that child to college more than doubles that amount. VOA’s Deborah Block visited with a couple with one child in Alexandria, Virginia, to learn if the report reflects their lifestyle.
Video

Video Chaotic Afghan Vote Recount Threatens Nation’s Future

Afghanistan’s troubled presidential election continues to be rocked by turmoil as an audit of the ballots drags on. The U.N. says the recount will not be completed before September 10. Observers say repeated disputes and delays are threatening the orderly transfer of power and could have dangerous consequences. VOA correspondent Meredith Buel reports.
Video

Video Ukraine Battles Pro-Russia Rebel Assault

After NATO concluded an emergency meeting to discuss the crisis in eastern Ukraine, the country is struggling to contain heavy fighting near the strategic port of Mariupol, on the Azov Sea. Separatist rebels are trying to capture the city, allegedly with Russian military help, and Ukraine's defense forces are digging in. VOA's Daniel Schearf spoke with analysts about what lies ahead for Ukraine.
Video

Video Growing Business Offers Paint with a Twist of Wine

Two New Orleans area women started a small business seven years ago with one thing in mind: to help their neighbors relieve the stress of coping with a hurricane's aftermath. Today their business, which pairs painting and a little bit of wine, has become one of the fastest growing franchises across the U.S. VOA’s June Soh met the entrepreneurs at their newest franchise location in the Washington suburbs.
Video

Video Ebola Vaccine Trials To Begin Next Week

The National Institutes of Health says it is launching early stage trials of a vaccine to prevent the Ebola virus, which has infected or killed thousands of people across West Africa. The World Health Organization says Ebola could infect more than 20,000 people across the region by the time the outbreak is over. The epidemic has health experts and governments scrambling to prevent more people from becoming infected. Zlatica Hoke has more.
Video

Video Asian Bacteria Threatens Florida Orange Trees

Florida's citrus fruit industry is facing a serious threat from a bacteria carried by the Asian insect called psyllid. The widespread infestation again highlights the danger of transferring non-native species to American soil. VOA’s George Putic reports.
Video

Video Aging Will Reduce Economic Growth Worldwide in Coming Decades

The world is getting older, fast. And as more people retire each year, fewer working-age people will be there to replace them. Bond rating agency Moody’s says that will lead to a decline in household savings; reducing global investments - which in turn, will lead to slower economic growth around the world. But experts say it’s not too late to mitigate the economic impact of the world’s aging populations. Mil Arcega has more.
Video

Video Is West Doing Enough to Tackle Islamic State?

U.S. President Barack Obama has ruled out sending ground troops to Iraq to fight militants of the so-called Islamic State, or ISIS, despite officials in Washington describing the extremist group as the biggest threat the United States has faced in years. Henry Ridgwell reports from London on the growing uncertainty over whether the West’s response to ISIS will be enough to defeat the terrorist threat.
Video

Video Coalition to Fight Islamic State Could Reward Assad

The United States along with European and Mideast allies are considering a broader assault against Islamic State fighters who have spread from Syria into Iraq and risk further destabilizing an already troubled region. But as VOA State Department Correspondent Scott Stearns reports, confronting those militants could end up helping the embattled Syrian President Bashar al-Assad.
Video

Video Made in America Socks Get Toehold in Online Fashion Market

Three young entrepreneurs are hoping to revolutionize the high-end sock industry by introducing all-American creations of their own. And they’re doing most of it the old-fashioned way. VOA’s Julie Taboh recently caught up with them to learn what goes into making their one-of-a-kind socks.
Video

Video Americans, Ex-Pats Send Relief Supplies to West Africa

Health organizations from around the world are sending supplies and specialists to the West African countries that are dealing with the worst Ebola outbreak in history. On a smaller scale, ordinary Americans and African expatriates living in the United States are doing the same. VOA's Carol Pearson reports.

AppleAndroid