News / Health

Latest Cancer Research Leads to Better Screening, New Drugs

DNA double helix is seen in an undated artist's illustration released by the National Human Genome Research InstituteDNA double helix is seen in an undated artist's illustration released by the National Human Genome Research Institute
x
DNA double helix is seen in an undated artist's illustration released by the National Human Genome Research Institute
DNA double helix is seen in an undated artist's illustration released by the National Human Genome Research Institute
Reuters
New research has nearly doubled the number of genetic variations implicated in breast, prostate and ovarian cancer, offering fresh avenues for screening at-risk patients and, potentially, developing better drugs.
       
The bumper haul of 74 gene changes that can increase risks for the three hormone-related cancers, announced by scientists on Wednesday, is the result of the largest ever study of its kind.
       
It follows an international project to analyse the DNA of more than 200,000 people - half of them with cancer and half from the general population - to find alterations that are more common in individuals with the disease.
       
Although each gene variation increases cancer risk by only a small amount, scientists calculate that the one percent of men carrying lots of the alterations could have a 50 percent increased risk of developing prostate cancer.
       
Women with multiple variants could see their risk of breast cancer increase by 30 percent.
       
Doug Easton of the University of Cambridge, one of the cancer researchers who led the work, said the batch of new genetic discoveries meant medical experts would be able to develop new cancer screening programs.
       
This will take time, since more research is needed to develop diagnostic tools.
       
"I would think that within five to 10 years this might be being used commonly, if not in a very widespread population base,'' said Paul Pharoah, also of the University of Cambridge.
       
Initially, the additional screening is likely to be targeted at patients with established cancer risk factors, such as carriers of BRCA gene faults. Women with BRCA faults are known to be at greater risk of developing breast and ovarian cancer.

New Drugs

Ros Eeles of Britain's Institute of Cancer Research, an expert in prostate cancer, said the new findings were the biggest leap forward yet in understanding the genetic basis of the disease.
       
"They allow us, for the first time, to identify men who have a very high risk of developing prostate cancer during their lifetime through inheritance of multiple risk genetic variants,'' she said.
       
In the case of prostate cancer, scientists found 23 new genetic variations - known as single nucleotide polymorphisms, or SNPs - taking the total to 78. Significantly, 16 were linked with the more aggressive forms of the disease.
       
For breast cancer the researchers found 49 new SNPs, more than doubling the number previously identified, and in ovarian cancer the tally was 11.
       
A few of the variations were common to more than one cancer type, suggesting there may be common mechanisms of action that could be targeted by new drugs.
       
Developing medicines using the insight gained by the latest research will take many years, even assuming that drugmakers can produce compounds that work effectively. Encouragingly, though, companies such as Roche, the market leader in cancer, are getting better at making drugs that apply biochemical brakes'' to tumor cells.
       
The scientists stressed that genes, while important, were just one side of a complex mix of factors leading to cancer.
       
"Lifestyle and environmental risks act in concert with the genetics. It is not one or the other - it is always both together,'' Pharoah told reporters.
       
The new research was published in a series of papers in Nature Genetics, Nature Communications, PLOS Genetics, and the American Journal of Human Genetics and Human Molecular Genetics.

You May Like

UN Watchdog Urges Israel to Probe Possible Gaza War Crimes

More than 2,100 Palestinians, most of them civilians, were killed in a 51-day war in Gaza, along with 67 Israeli soldiers and six civilians in Israel More

New Kenyan 'Thin SIMs' Poised to Transform African Mobile Money

Equity's new technology is approved in African nation for one-year trial, though industry leader Safaricom says thin SIMs could lead to data theft and fraud More

Solar's Future Looks Brighter

New technology and dropping prices are contributing to a surge in solar power More

This forum has been closed.
Comment Sorting
Comments
     
by: hesham mostafa from: egypt
March 29, 2013 9:23 AM
It is an authentic breakthrough in cancer exploration. A clinical trial pointed out that they managed to cut down 3-year fatality rate in people with metastatic cancer malignancy by more than 5 times. Nothing is identical to this effect in the whole oncological research. Once more 5 times fewer people past away in 3 years after they taught one additional therapy.

The treatment was based on the process utilized by almost 200 Russian medical experts, and the objective of the process is to enhance oxygen content in cells by means of the legendary Buteyko respiratory method. These awesome results are reported and all details of their treatment solution are stated in the Kindle book from Amazon “Doctors Who Cure Cance"r Dr. Artour Rakhimov. Once you see a person with cancer, I ask you to share!
http://www.amazon.com/Doctors-Cure-Cancer-Books-ebook/dp/B007IZZ4AQ/

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
Talks to Resume on Winter Gas for Ukrainei
X
Al Pessin
October 25, 2014 4:21 PM
Ukrainian and Russian officials will meet again next week in an effort to settle their dispute over natural gas supplies that threatens to leave Ukraine short of heating fuel for the coming winter. VOA’s Al Pessin reports from London the dispute is complex, and has both economic and geopolitical dimensions.
Video

Video Talks to Resume on Winter Gas for Ukraine

Ukrainian and Russian officials will meet again next week in an effort to settle their dispute over natural gas supplies that threatens to leave Ukraine short of heating fuel for the coming winter. VOA’s Al Pessin reports from London the dispute is complex, and has both economic and geopolitical dimensions.
Video

Video Smugglers Offer Cheap Passage From Turkey to Syria

Smugglers in Turkey offer a relatively cheap passage across the border into Syria. Ankara has stepped up efforts to stem the flow of foreign fighters who want to join Islamic State militants fighting for control of the Syrian border city of Kobani. But porous borders and border guards who can be bribed make illegal border crossings quite easy. Zlatica Hoke has more.
Video

Video China Political Meeting Seeks to Improve Rule of Law

China’s communist leaders will host a top level political meeting this week, called the Fourth Plenum, and for the first time in the party’s history, rule of law will be a key item on the agenda. Analysts and Chinese media reports say the meetings could see the approval of long-awaited measures aimed at giving courts more independence and include steps to enhance an already aggressive and high-reaching anti-corruption drive. VOA’s Bill Ide has more from Beijing.
Video

Video After Decades of Pressure, Luxembourg Drops Bank Secrecy Rules

European Union finance ministers have reached a breakthrough agreement that will make it more difficult for tax cheats to hide their money. The new legislation, which had been blocked for years by countries with a reputation as tax havens, was approved last week after Luxembourg and Austria agreed to lift their vetoes. But as Mil Arcega reports, it doesn’t mean tax cheats have run out of places to keep their money hidden.
Video

Video Kobani Refugees Welcome, Turkey Criticizes, US Airdrop

Residents of Kobani in northern Syria have welcomed the airdrop of weapons, ammunition and medicine to Kurdish militia who are resisting the seizure of their city by Islamic State militants. The Turkish government, however, has criticized the operation. VOA’s Scott Bobb reports from southeastern Turkey, across the border from Kobani.
Video

Video US ‘Death Cafes’ Put Focus on the Finale

In contemporary America, death usually is a topic to be avoided. But the growing “death café” movement encourages people to discuss their fears and desires about their final moments. VOA’s Jerome Socolovsky reports.
Video

Video Ebola Orphanage Opens in Sierra Leone

Sierra Leone's first Ebola orphanage has opened in the Kailahun district. Hundreds of children orphaned since the beginning of the Ebola outbreak face stigma and rejection with nobody to care for them. Adam Bailes reports for VOA about a new interim care center that's aimed at helping the growing number of children affected by Ebola.

All About America

AppleAndroid