News / Health

Latest Cancer Research Leads to Better Screening, New Drugs

DNA double helix is seen in an undated artist's illustration released by the National Human Genome Research InstituteDNA double helix is seen in an undated artist's illustration released by the National Human Genome Research Institute
x
DNA double helix is seen in an undated artist's illustration released by the National Human Genome Research Institute
DNA double helix is seen in an undated artist's illustration released by the National Human Genome Research Institute
Reuters
New research has nearly doubled the number of genetic variations implicated in breast, prostate and ovarian cancer, offering fresh avenues for screening at-risk patients and, potentially, developing better drugs.
       
The bumper haul of 74 gene changes that can increase risks for the three hormone-related cancers, announced by scientists on Wednesday, is the result of the largest ever study of its kind.
       
It follows an international project to analyse the DNA of more than 200,000 people - half of them with cancer and half from the general population - to find alterations that are more common in individuals with the disease.
       
Although each gene variation increases cancer risk by only a small amount, scientists calculate that the one percent of men carrying lots of the alterations could have a 50 percent increased risk of developing prostate cancer.
       
Women with multiple variants could see their risk of breast cancer increase by 30 percent.
       
Doug Easton of the University of Cambridge, one of the cancer researchers who led the work, said the batch of new genetic discoveries meant medical experts would be able to develop new cancer screening programs.
       
This will take time, since more research is needed to develop diagnostic tools.
       
"I would think that within five to 10 years this might be being used commonly, if not in a very widespread population base,'' said Paul Pharoah, also of the University of Cambridge.
       
Initially, the additional screening is likely to be targeted at patients with established cancer risk factors, such as carriers of BRCA gene faults. Women with BRCA faults are known to be at greater risk of developing breast and ovarian cancer.

New Drugs

Ros Eeles of Britain's Institute of Cancer Research, an expert in prostate cancer, said the new findings were the biggest leap forward yet in understanding the genetic basis of the disease.
       
"They allow us, for the first time, to identify men who have a very high risk of developing prostate cancer during their lifetime through inheritance of multiple risk genetic variants,'' she said.
       
In the case of prostate cancer, scientists found 23 new genetic variations - known as single nucleotide polymorphisms, or SNPs - taking the total to 78. Significantly, 16 were linked with the more aggressive forms of the disease.
       
For breast cancer the researchers found 49 new SNPs, more than doubling the number previously identified, and in ovarian cancer the tally was 11.
       
A few of the variations were common to more than one cancer type, suggesting there may be common mechanisms of action that could be targeted by new drugs.
       
Developing medicines using the insight gained by the latest research will take many years, even assuming that drugmakers can produce compounds that work effectively. Encouragingly, though, companies such as Roche, the market leader in cancer, are getting better at making drugs that apply biochemical brakes'' to tumor cells.
       
The scientists stressed that genes, while important, were just one side of a complex mix of factors leading to cancer.
       
"Lifestyle and environmental risks act in concert with the genetics. It is not one or the other - it is always both together,'' Pharoah told reporters.
       
The new research was published in a series of papers in Nature Genetics, Nature Communications, PLOS Genetics, and the American Journal of Human Genetics and Human Molecular Genetics.

You May Like

UN: 1 Million Somalis at Risk of Hunger

Group warns region is in dire need of humanitarian aid, with at least 200,000 children under age of five acutely malnourished as drought hits southern, central part of nation More

Human Rights Groups Allege Supression of Freedoms in Thailand

Thailand’s military, police have suppressed release of independent report assessing human rights in kingdom during first 100 days of latest coup More

Jennifer Lawrence Contacts FBI After Nude Photos Hacked

'Silver Linings Playbook' actress' photos were posted on image-sharing forum 4chan; Federal Bureau of Investigations is looking into matter More

This forum has been closed.
Comment Sorting
Comments
     
by: hesham mostafa from: egypt
March 29, 2013 9:23 AM
It is an authentic breakthrough in cancer exploration. A clinical trial pointed out that they managed to cut down 3-year fatality rate in people with metastatic cancer malignancy by more than 5 times. Nothing is identical to this effect in the whole oncological research. Once more 5 times fewer people past away in 3 years after they taught one additional therapy.

The treatment was based on the process utilized by almost 200 Russian medical experts, and the objective of the process is to enhance oxygen content in cells by means of the legendary Buteyko respiratory method. These awesome results are reported and all details of their treatment solution are stated in the Kindle book from Amazon “Doctors Who Cure Cance"r Dr. Artour Rakhimov. Once you see a person with cancer, I ask you to share!
http://www.amazon.com/Doctors-Cure-Cancer-Books-ebook/dp/B007IZZ4AQ/

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
Ukraine Schools Resume Classes, Donate to Government Forcesi
X
September 02, 2014 12:58 PM
A new school year has started in Ukraine but thousands of children in the war-torn east are unable to attend because of ongoing clashes with pro-Russia rebels. In Ukraine's capital, patriotic education has become the norm along with donations to support injured security forces fighting to take back rebel-held areas. VOA's Daniel Schearf reports from Kyiv.
Video

Video Ukraine Schools Resume Classes, Donate to Government Forces

A new school year has started in Ukraine but thousands of children in the war-torn east are unable to attend because of ongoing clashes with pro-Russia rebels. In Ukraine's capital, patriotic education has become the norm along with donations to support injured security forces fighting to take back rebel-held areas. VOA's Daniel Schearf reports from Kyiv.
Video

Video US Detainees Want Negotiators for Freedom in North Korea

The three U.S. detainees held in North Korea were permitted to speak with foreign media Monday. The government of Kim Jong Un restricted the topics of the questions, and the interviews in Pyongyang were limited to five minutes. Each of the men asked Washington to send a representative to Pyongyang to secure his release. VOA’s Carolyn Presutti has our story.
Video

Video Internet, Technology Offer New Tools for Journalists

The Internet and rapidly evolving technology is quickly changing how people receive news and how journalists deliver it. There are now more ways to tell a story than ever before. One school in Los Angeles is teaching the next generation of journalists with the help of a state-of-the-art newsroom. Elizabeth Lee has this report.
Video

Video Turkmen From Amerli Describe Survival of IS Siege

Over the past few weeks, hundreds of Shi'ite Turkmen have fled the town of Amerli seeking refuge in the northern city of Kirkuk. Despite recent military gains after U.S. airstrikes that were coordinated with Iraqi and Kurdish forces, the situation remains dire for Amerli’s residents. Sebastian Meyer went to Kirkuk for VOA to speak to those who managed to escape.
Video

Video West Africa Ebola Vaccine Trials Possible by Early 2015

A U.S. health agency is speeding up clinical trials of a possible vaccine against the deadly Ebola virus that so far has killed more than 1,500 people in West Africa. If successful, the next step would be a larger trial in countries where the outbreak is occurring. VOA's Carol Pearson has more.
Video

Video Survivors Commemorate 70th Anniversary of Nazi Liquidation of Jewish Ghetto

When the German Nazi army occupied the Polish city of Lodz in 1939, it marked the beginning of a long nightmare for the Jewish community that once made up one third of the population. Roughly 200,000 people were forced into the Lodz Ghetto. Less than 7,000 survived. As VOA’s Kane Farabaugh reports, some survivors gathered at the Union League Club in Chicago on the 70th anniversary of the liquidation of the Lodz Ghetto to remember those who suffered at the hands of the Nazi regime.
Video

Video Cost to Raise Child in US Continues to Rise

The cost of raising a child in the United States continues to rise. In its latest annual report, the U.S. Department of Agriculture says middle income families with a child born in 2013 can expect to spend more than $240,000 before that child turns 18. And sending that child to college more than doubles that amount. VOA’s Deborah Block visited with a couple with one child in Alexandria, Virginia, to learn if the report reflects their lifestyle.
Video

Video Chaotic Afghan Vote Recount Threatens Nation’s Future

Afghanistan’s troubled presidential election continues to be rocked by turmoil as an audit of the ballots drags on. The U.N. says the recount will not be completed before September 10. Observers say repeated disputes and delays are threatening the orderly transfer of power and could have dangerous consequences. VOA correspondent Meredith Buel reports.

AppleAndroid