News / Health

    Dengue Fever Vaccine Trials Clear First Hurdle

    Jessica Berman
    Human trials of an experimental dengue fever vaccine have just concluded, and the experimental compound looks promising in offering protection against the complex mosquito-borne illness that afflicts millions of people living in tropical and sub-tropical regions.

    Dengue fever, spread by the bite of an infected Aedes mosquito, is caused by four different but related viruses, making the development of a vaccine difficult, according to Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases.

    “The problem with a dengue vaccine is that unlike other viruses where if you get infected with one or vaccinated with one you’re protected, period, after you recover.  Whereas with dengue since there are four types, a vaccine needs to protect you against all four, because if you are only protected against one or two, you are still susceptible to one or the other of the three or four viruses,” Fauci said.

    The U.S. government-funded trial was small, involving 112 healthy men and women between the ages of 18 and 50.  The purpose was to see whether the experimental vaccine, made up of live but weakened viruses, was both safe and stimulated an antibody response against all four dengue types.

    Researchers at Johns Hopkins School of Public Health in Baltimore, Maryland formulated four different versions of the combination vaccine, and tested a separate vaccine in each of four groups of 20 study participants.  All of the dengue vaccines produced an antibody response.  But one experimental compound, called TV003, induced an immune response against all four dengue viruses in 45 percent of participants.  And an immune response to three viruses was seen in about 90 percent of participants.

    The combination vaccine was safe, producing only a faint rash in about 60 percent of the participants, according to Fauci.

    “I’m cautiously optimistic that we will have a vaccine after a period of time.  But again, this is in [the very early] stages - only a Phase One trial,” Fauci said.

    The experimental dengue vaccine will undergo more safety and effectiveness testing in Phase 2 and Phase 3 trials, with researchers looking to see how well it creates an immune response against all four dengue viruses in Brazil and Thailand, where the mosquito-borne illness is endemic.

    Dengue fever, also known as break bone fever, infects an estimated 50 million to 00 million people in developing countries each year.  Experts say the vaccine should cost less than $1 dollar a dose to produce, making it accessible to developing countries most impacted by the disease.

    You May Like

    Ugandan Opposition Candidate: Only Intimidation, Vote Buying Can Prevent Victory

    Kizza Besigye says he has been drawing large crowds and claims he has widespred support ahead of Feb. 18 vote

    HRW: Both Sides in Ukraine Conflict Targeted, Used Schools

    Rights group documents how both sides in Ukraine conflict carried out attacks on schools and used them for military purposes

    Sanctions Just Got Real for Over 54,000 North Koreans

    Shuttering of Kaesong complex ends virtually any hope of peaceful settlement to long-standing tensions on Korean peninsula in near future

    Featured Videos

    Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
    Russia's Car Sales Shrink Overall, But Luxury and Economy Models See Growthi
    X
    February 10, 2016 5:54 AM
    Car sales in Russia dropped by more than a third in 2015 because of the country's economic woes. But, at the extreme ends of the car market, luxury vehicles and some economy brands are actually experiencing growth. VOA's Daniel Schearf reports from Moscow.
    Video

    Video Russia's Car Sales Shrink Overall, But Luxury and Economy Models See Growth

    Car sales in Russia dropped by more than a third in 2015 because of the country's economic woes. But, at the extreme ends of the car market, luxury vehicles and some economy brands are actually experiencing growth. VOA's Daniel Schearf reports from Moscow.
    Video

    Video Civil Rights Pioneer Remembers Struggle for Voting Rights

    February is Black History Month in the United States. The annual, month-long national observance pays tribute to important people and events that shaped the history of African Americans. VOA's Chris Simkins reports how one man fought against discrimination to help millions of blacks obtain the right to vote
    Video

    Video Jordanian Theater Group Stages Anti-Terrorism Message

    The lure of the self-styled “Islamic State” has many parents worried about their children who may be susceptible to the organization’s online propaganda. Dozens of Muslim communities in the Middle East are fighting back -- giving young adults alternatives to violence. One group in Jordan is using dramatic expression a send a family message. Mideast Broadcasting Network correspondent Haider Al Abdali shared this report with VOA. It’s narrated by Bronwyn Benito
    Video

    Video Migrant Crisis Fuels Debate Over Britain’s Future in EU

    The migrant crisis in Europe is fueling the debate in Britain ahead of a referendum on staying in the European Union that may be held this year. Prime Minister David Cameron warns that leaving the EU could lead to thousands more migrants arriving in the country. Meanwhile, tension is rising in Calais, France, where thousands of migrants are living in squalid camps. VOA's Henry Ridgwell reports.
    Video

    Video Valentine's Day Stinks for Lebanese Clowns

    This weekend, on Valentine's Day in Lebanon, love is not the only thing in the air. More than half a year after the country's trash crisis began, the stink of uncollected garbage remains on the streets. Step forward "Clown Me In," a group of clowns who use their skills for activism. Before the most romantic day of the year the clowns have released their unusual take on love in Lebanon -- in a bid to keep the pressure up and get the trash off the streets. John Owens reports from Beirut.
    Video

    Video Families Flee Aleppo for Kurdish Regions in Syria

    Not all who flee the fighting in Aleppo are trying to cross the border into Turkey. A VOA reporter caught up with several families heading for Kurdish-held areas of northern Syria.
    Video

    Video Rocky Year Ahead for Nigeria Amid Oil Price Crash

    The global fall in the price of oil has rattled the economies of many petroleum exporters, and Africa’s oil king Nigeria is no exception. As Chris Stein reports from Lagos, analysts are predicting a rough year ahead for the continent’s top producer of crude.
    Video

    Video 'No Means No' Program Targets Sexual Violence in Kenya

    The organizers of an initiative to reduce and stop rape in the informal settlements around Kenya's capital say their program is having marked success. Girls are taking self-defense classes while the boys are learning how to protect the girls and respect them. Lenny Ruvaga reports from Nairobi.
    Video

    Video Chocolate Lovers Get a Sweet History Lesson

    Observed in many countries around the world, Valentine’s Day is sometimes celebrated with chocolate festivals. But at a festival near Washington, the visitors experience a bit more than a sugar rush. They go on a sweet journey through history. VOA’s June Soh takes us to the festival.
    Video

    Video 'Smart' Bandages Could Heal Wounds More Quickly

    Simple bandages are usually seen as the first line of attack in healing small to moderate wounds and burns. But scientists say new synthetic materials with embedded microsensors could turn bandages into a much more valuable tool for emergency physicians. VOA’s George Putic reports.
    Video

    Video Researchers Use 3-D Printer to Produce Transplantable Body Parts

    Human organ transplants have become fairly common around the world in the past few decades. Researchers at various universities are coordinating their efforts to find solutions -- including teams at the University of Pennsylvania and Rice University in Houston that are experimenting with a 3-D printer -- to make blood vessels and other structures for implant. As VOA’s Greg Flakus reports from Houston, they are also using these artificial body parts to seek ways of defeating cancerous tumors.
    Video

    Video Helping the Blind 'See' Great Art

    There are 285 million blind and visually impaired people in the world who are unable to enjoy visual art at a museum. One New York photographer is trying to fix this situation by making tangible copies of the world’s masterpieces. VOA correspondent Victoria Kupchinetsky was there as visually impaired people got a feel for great art. Joy Wagner narrates her report.
    Video

    Video German Artists to Memorialize Refugees With Life Jacket Exhibit

    Sold in every kind of shop in some Turkish port towns, life jackets have become a symbol of the refugee crisis that brought a million people to Europe in 2015.  On the shores of Lesbos, Greece, German artists collect discarded life jackets as they prepare an art installation they plan to display in Germany.  For VOA, Hamada Elrasam has this report from Lesbos, Greece.
    Video

    Video E-readers Help Ease Africa's Book Shortage

    Millions of people in Africa can't read, and there's a chronic shortage of books. A non-profit organization called Worldreader is trying to help change all that one e-reader at a time. VOA’s Deborah Block tells us about a girls' school in Nairobi, Kenya where Worldreader is making a difference.