News / Health

    Drug Combo Could Advance Fight Against Multi-Drug-Resistant TB

    FILE - A doctor examines chest X-rays at a tuberculosis clinic in Cape Town, South Africa.
    FILE - A doctor examines chest X-rays at a tuberculosis clinic in Cape Town, South Africa.
    Jessica Berman

    The U.S. Centers for Disease Control and Prevention, or CDC, estimates 10 million people became sick and 1.5 million died in 2014 as a result of multi-drug-resistant tuberculosis. Without an effective and aggressive treatment strategy, the number of cases could rise to 75 million worldwide by 2050.

    A new study concludes that a combination of at least six drugs may be needed to combat the growing health menace.

    Multi-drug-resistant tuberculosis bacteria. (Credit: U.S. Centers for Disease Control and Prevention)Multi-drug-resistant tuberculosis bacteria. (Credit: U.S. Centers for Disease Control and Prevention)
    x
    Multi-drug-resistant tuberculosis bacteria. (Credit: U.S. Centers for Disease Control and Prevention)
    Multi-drug-resistant tuberculosis bacteria. (Credit: U.S. Centers for Disease Control and Prevention)

    "If we don't act promptly, if we don't act now, then the problem of drug-resistant TB will just get worse," said Peter Cegielski, team leader for Drug-Resistant TB and Infection Control in the global TB branch at the CDC.

    Cegielski says that when a person is infected with multi-drug-resistant — or MDR — TB, the bacterium that causes the disease does not respond to two gold-standard drugs for treating the illness: isoniazid and rifampicin.

    So doctors turn to a cocktail of many more-expensive but less-effective drugs.

    How many drugs should be in that cocktail was the focus of a study led by Cegielski. 

    Six over five

    Currently, the World Health Organization recommends that five drugs be administered simultaneously.

    But the study, conducted at 26 sites in nine countries, found that using six drugs could provide a necessary boost in efforts to defeat MDR-TB.

    FILE - An inmate sits in the multi-drug-resistant tuberculosis ward in a prison hospital in Russia.
    FILE - An inmate sits in the multi-drug-resistant tuberculosis ward in a prison hospital in Russia.

    Participating countries included Russia, South Africa, Taiwan and Estonia.

    Among the 1,100 adult patients in the study with MDR-TB, those who received six potentially effective drugs saw a 36 percent greater likelihood of responding to treatment compared with those who received five or fewer drugs. The findings were published in the journal PLoS Medicine.

    Conducting pre-treatment testing also helped to determine which drugs were most likely to be effective against resistant TB infections, according to Cegielski.

    "So, it was clear from this work that more testing for drug resistance, and especially testing for the full range of drug resistance, would be important so that physicians can choose the most effective drugs based on those laboratory results," he said.

    The WHO is now encouraging doctors around the world to do drug-sensitivity testing prior to treating their MDR-TB patients, Cegielski said.

    Meanwhile, the Obama administration unveiled an action plan to bring resources to bear in the prompt identification and treatment of patients infected with multi-drug-resistant tuberculosis.

    You May Like

    US Lawmakers Vow to Continue Immigrant Program for Afghan Interpreters

    Congressional inaction threatens funding for effort which began in 2008 and has allowed more than 20,000 interpreters, their family members to immigrate to US

    Brexit's Impact on Russia Stirs Concern

    Some analysts see Brexit aiding Putin's plans to destabilize European politics; others note that an economically unstable Europe is not in Moscow's interests

    US to Train Cambodian Government on Combating Cybercrime

    Concerns raised over drafting of law, as critics fear cybercrime regulations could be used to restrict freedom of expression and stifle political dissent

    This forum has been closed.
    Comments
         
    There are no comments in this forum. Be first and add one

    Featured Videos

    Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
    Baghdad Bikers Defy War with a Roari
    X
    June 28, 2016 10:33 AM
    Baghdad is a city of contradictions. War is a constant. Explosions and kidnappings are part of daily life. But the Iraqi capital remains a thriving city, even if a little beat up. VOA's Sharon Behn reports on how some in Baghdad are defying the stereotype of a nation at war by pursuing a lifestyle known for its iconic symbols of rebellion: motorbikes, leather jackets and roaring engines.
    Video

    Video Baghdad Bikers Defy War with a Roar

    Baghdad is a city of contradictions. War is a constant. Explosions and kidnappings are part of daily life. But the Iraqi capital remains a thriving city, even if a little beat up. VOA's Sharon Behn reports on how some in Baghdad are defying the stereotype of a nation at war by pursuing a lifestyle known for its iconic symbols of rebellion: motorbikes, leather jackets and roaring engines.
    Video

    Video Melting Pot of Immigrants Working to Restore US Capitol Dome

    The American Iron Works company is one of the firms working to renovate the iconic U.S. Capitol Dome. The company employs immigrants of many different cultural and national backgrounds. VOA’s Arman Tarjimanyan has more.
    Video

    Video Testing Bamboo as Building Material

    For thousands of years various species of bamboo - one of the world's most versatile plants - have been used for diverse purposes ranging from food and medicine to textiles and construction. But its use on a large scale is hampered because it's not manufactured to specific standards but grown in the ground. A University of Pittsburgh professor is on track to changing that. VOA’s George Putic reports.
    Video

    Video Orphanage in Iraqi City Houses Kids Who Lost their Parents to Attacks by IS

    An orphanage in Iraqi Kurdistan has become home to scores of Yazidi children who lost their parents after Islamic State militants took over Sinjar in Iraq’s Nineveh Province in 2014. Iraqi Kurdish forces backed by the U.S. airstrikes have since recaptured Sinjar but the need for the care provided by the orphanage continues. VOA’s Kawa Omar filed this report narrated by Rob Raffaele.
    Video

    Video Re-Opening Old Wounds in a Bullet-Riddled Cultural Landmark

    A cultural landmark before Lebanon’s civil war transformed it into a nest of snipers, Beirut’s ‘Yellow House’ is once again set to play a crucial role in the city.  Built in a neo-Ottoman style in the 1920s, in September it is set to be re-opened as a ‘memory museum’ - its bullet-riddled walls and bunkered positions overlooking the city’s notorious ‘Green Line’ maintained for posterity. John Owens reports from Beirut.
    Video

    Video Brexit Resounds in US Presidential Contest

    Britain’s decision to leave the European Union is resounding in America’s presidential race. As VOA’s Michael Bowman reports, Republican presumptive nominee Donald Trump sees Britain’s move as an affirmation of his campaign’s core messages, while Democrat Hillary Clinton sees the episode as further evidence that Trump is unfit to be president.
    Video

    Video New York Pride March A Celebration of Life, Mourning of Loss

    At this year’s march in New York marking the end of pride week, a record-breaking crowd of LGBT activists and allies marched down Manhattan's Fifth Avenue, in what will be long remembered as a powerful display of solidarity and remembrance for the 49 victims killed two weeks ago in an Orlando gay nightclub.
    Video

    Video NASA Juno Spacecraft, Nearing Jupiter, to Shed Light on Gas Giant

    After a five-year journey, the spacecraft Juno is nearing its destination, the giant planet Jupiter, where it will enter orbit and start sending data back July 4th. As Mike O'Sullivan reports from Pasadena, California, the craft will pierce the veil of Jupiter's dense cloud cover to reveal its mysteries.
    Video

    Video Orlando Shooting Changes Debate on Gun Control

    It’s been nearly two weeks since the largest mass shooting ever in the United States. Despite public calls for tighter gun control laws, Congress is at an impasse. Democratic lawmakers resorted to a 1960s civil rights tactic to portray their frustration. VOA’s Carolyn Presutti explains how the Orlando, Florida shooting is changing the debate.
    Video

    Video Tunisian Fishing Town Searches for Jobs, Local Development Solutions

    As the European Union tries to come to grips with its migrant crisis, some newcomers are leaving voluntarily. But those returning to their home countries face an uncertain future.  Five years after Tunisia's revolution, the tiny North African country is struggling with unrest, soaring unemployment and plummeting growth. From the southern Tunisian fishing town of Zarzis, Lisa Bryant takes a look for VOA at a search for local solutions.
    Video

    Video 'American Troops' in Russia Despite Tensions

    Historic battle re-enactment is a niche hobby with a fair number of adherents in Russia where past military victories are played-up by the Kremlin as a show of national strength. But, one group of World War II re-enactors in Moscow has the rare distinction of choosing to play western ally troops. VOA's Daniel Schearf explains.
    Video

    Video Muslim American Mayor Calls for Tolerance

    Syrian-born Mohamed Khairullah describes himself as "an American mayor who happens to be Muslim." As the three-term mayor of Prospect Park, New Jersey, he believes his town of 6,000 is an example of how ethnicity and religious beliefs should not determine a community's leadership. Ramon Taylor has this report from Prospect Park.

    Special Report

    Adrift The Invisible African Diaspora