News / Health

Female Hormone Estrogen Blocks Ebola Virus Infection

Jessica Berman
Researchers have discovered that drugs containing female estrogen block infection with the Ebola virus, a deadly disease for which there is no cure.  Scientists stumbled upon estrogen as a potential weapon against Ebola while looking to find new uses for old drugs.

Ebola hemorrhagic virus is named after a river in the Democratic Republic of Congo in Africa, the continent where the disease is endemic.  The infection, discovered in 1976, is extremely deadly, with a mortality rate of up to 90 percent.  And amid concerns that the highly lethal virus could be weaponized by bioterrorists, scientists have been looking for ways to prevent infection with Ebola.

Lisa Johansen, director of research programs at Zalicus, a biotechnology company located in Cambridge, Massachusetts, says she and researchers at the U.S. Army Medical Research Institute of Infectious Diseases in Maryland and at the University of Virginia in Charlottesville screened 2,000 existing drugs, looking for chemical compounds that were effective against Ebola.

Investigators discovered that a number of human-made drugs, including selective estrogen receptor modulators, or SERMS, blocked Ebola’s entry into cells in lab cultures and in mice.

But it wasn’t the estrogen drugs’ hormonal activity that thwarted the Ebola virus, preventing infection.  

Rather, Johansen says it was the compound’s chemical structure, and the structure of a number of other drugs, that hindered the microorganism, something that surprised researchers.    

“I think that’s one of the things that’s exciting…When we looked at our inhibitors, we found that a lot of them are entry inhibitors.  And a lot of them have the structure even though the mechanism is for something completely unrelated,” Johansen said.

SERMS are so-called designer drugs designed to act like estrogen without negative side effects.  For example, Tamoxifen is an older SERM used to treat breast cancer and the newer Reloxifen is approved for the prevention and treatment of the bone-weakening condition osteoporosis.  But they have potentially serious side effects such as an increased risk of other types of cancer.

Johansen envisions using SERMS and other repurposed compounds in a number of situations to prevent infection and death.

“I think they could be used both by a civilian population where outbreaks are as well as potentially by the military if they were in an area where there was an outbreak and they went in to intercede, or if somebody used them for bio-warfare,” Johansen said.

An article on using estrogen drugs and other compounds to prevent Ebola virus infection is published in the journal Science Translational Medicine.

You May Like

Obama: I Will Do 'Everything I Can' to Close Guantanamo

US president says prison continues 'to inspire jihadists and extremists around the world' More

Sierra Leone Educates on Safe Ebola Burials

Also, country is improving at rapid response to isolated outbreaks, but health workers need to be even faster, officials say More

Religion Aside, Christmas Gains Popularity in Communist Vietnam

Increasingly wealthy Vietnamese embrace holiday due to its non-religious glamor, commercial appeal More

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
US Decision on Cuba Underscores Divisions Among Miami Cubansi
X
Sharon Behn
December 19, 2014 9:34 PM
For decades, older, more conservative Cubans have been gathering at Café Versailles on the corner of Calle Ocho to eat Cuban food and talk politics. After hearing of President Barack Obama’s decision, a number of them gathered in front of the café with posters to protest. VOA's Sharon Behn reports on the situation.
Video

Video US Decision on Cuba Underscores Divisions Among Miami Cubans

For decades, older, more conservative Cubans have been gathering at Café Versailles on the corner of Calle Ocho to eat Cuban food and talk politics. After hearing of President Barack Obama’s decision, a number of them gathered in front of the café with posters to protest. VOA's Sharon Behn reports on the situation.
Video

Video Three Cities Bid for Future Obama Presidential Library

President Barack Obama still has two years left in his term in office, but the effort to establish his post-presidential library is already underway. The bid for the Obama Presidential Library is down to four locations in three states -- New York, Hawaii, and Illinois. As VOA’s Kane Farabaugh reports, each of them played an important part in the president’s life before he reached the White House.
Video

Video Cuba Deal is Major Victory for Pope’s Diplomatic Initiatives

Pope Francis played a key role in brokering the US-Cuba deal that was made public earlier this week. It is the most stunning success so far in a series of peacemaking efforts by the pontiff. VOA religion reporter Jerome Socolovsky has more.
Video

Video Fears of More Political Gridlock in 2015

2014 proved to be a difficult year politically for President Barack Obama and a very good year for the U.S. Republican Party. Republican gains in the November midterm elections gave them control of the Senate and House of Representatives for the next two years -- setting the stage for more confrontation and gridlock in the final two years of the Obama presidency. VOA National Correspondent Jim Malone has a preview from Washington.
Video

Video Sudan School Becomes Target of Aerial Attacks

The school dropout rate is at an all-time high in Sudan's South Kordofan state because many schools have been destroyed during the three-year civil war between the government and SPLA-N rebel forces. Adam Bailes visited Sudan's Nuba Mountains' region and reports many children are simply too scared to go to school
Video

Video VOA Reporter Tours Devastated Peshawar School

Islamist militants wearing military uniforms and strapped with explosives attacked a military run school Tuesday in the northwestern Pakistani city of Peshawar. At least 141 people were killed in the horrific attack, most of them young students. VOA reporter Ayaz Gul visited the devastated school and attended the funeral of the principal who courageously tried to save her students from the deadly attack.
Video

Video Nigerians Fleeing Boko Haram Languish in Camp Near Capital

In its five-year effort to impose Islamic law in northeastern Nigeria, the Boko Haram extremist group has killed thousands of people and forced hundreds of thousands to flee. Some of those who ran for their lives now live in squalor on the edges of the capital, Abuja. Chris Stein reports for VOA.
Video

Video Aceh Rebuilt Decade After Tsunami, But Scars Remain

On December 26, 2004 there was an earthquake in the Indian Ocean so powerful it caused the Earth’s axis to wobble a few centimeters. Onshore on the island of Sumatra, the resulting tsunami was devastating. A decade later, VOA Correspondent Steve Herman reports from Banda Aceh, Indonesia, where although there is little remaining evidence of the physical devastation, the psychological scars among survivors remain.

All About America

AppleAndroid