News / Health

Experimental Malaria Vaccine Weakens Parasite

A young girl with malaria rests in the inpatient ward of the Malualkon Primary Health Care Center in Malualkon, in the South Sudanese state of Northern Bahr el Ghazal, June 1, 2012.
A young girl with malaria rests in the inpatient ward of the Malualkon Primary Health Care Center in Malualkon, in the South Sudanese state of Northern Bahr el Ghazal, June 1, 2012.
Jessica Berman
Scientists are developing a vaccine against malaria that is designed to limit the illness in children who have been bitten by mosquitoes carrying the disease-causing organism.  They have discovered a protein that is essential for malaria parasites to cause severe illness.

With the protein, called SEA, the parasite is able to burst through infected red blood cells, ramping up disease symptoms. But malaria parasites deprived of SEA are trapped inside the cells where they wither away and are eventually eliminated from the body by the spleen.  

Researchers at Brown University in Providence, Rhode Island, and Boston Children’s Hospital in Massachusetts discovered the protein.  

Jonathan Kurtis is director of the Center for International Health Research at Rhode Island Hospital and lead author of the study which appears in the journal Science.

Kurtis says an experimental vaccine containing antibodies against the parasitic protein was developed and tested in mice.  Rodents that received the vaccine were only mildly sick and had fewer parasites in their bodies than untreated mice.

Next, Kurtis says investigators measured levels of antibodies to the SEA protein in a group of 785 Tanzanian children.

“And children with antibodies to our protein never got severe malaria - there were zero cases - as compared to children who did not have antibodies to our protein,” Kurtis said.
 
Malaria mortality rates, 2000 - 2012Malaria mortality rates, 2000 - 2012
x
Malaria mortality rates, 2000 - 2012
Malaria mortality rates, 2000 - 2012
Researchers then analyzed blood samples collected in 1997 from 140 children in Kenya.  Investigators found there were 50 percent fewer parasites in the serum of youngsters that produced antibodies to SEA during a high transmission season.  As with the Tanzanian children, there were also no severe cases of the disease in children with antibodies against the protein, according to Kurtis.

“And so the thought is by immunizing people with the SEA proteins, so that they make their own antibodies, they’ll be protected,” he added.

The next step, Kurtis says, is to test a laboratory-made SEA vaccine to see whether it works in primates.

Kurtis says he’s excited that researchers may be on the verge of an effective drug that lessens the severity of a malaria infection, but he’s also humbled.

“Our eye has to be on the prize.  And the prize is - you’ve got a child every 15 seconds, just during this phone conversation, you know dozens and dozens of children have died of malaria,” Kurtis said. "It’s just unbelievable.”

If the vaccine proves to be safe and effective in monkeys within the next  year, researchers expect they’ll move quickly to human vaccine trials.  

Kurtis says the goal eventually is to immunize youngsters in malaria-endemic regions at the same time they are vaccinated against other childhood illnesses.

You May Like

Unpaid Kurdish Fighters Sign of Economic Woes

Sharp cuts in Kurdistan's budget by Baghdad, falling oil revenue, coping with refugees, inflated public sector have hit regional economy hard More

Koreas Exchange List of Envoys for Family Reunion Talks

Officials will discuss date, venue and number of participants for reunion; Seoul hopes to hold event late this month More

China Targets 197 in Online Speech Crackdown

Nearly 200 punished for 'spreading rumors' online in ongoing crackdown on free speech More

This forum has been closed.
Comment Sorting
Comments
     
by: Donald Fraser Miles from: Elliot Lake, Canada
May 24, 2014 8:36 AM
My own theory on malaria which I communicated years ago is that the male mosquito creates protection against the malaria parasite. Only female mosquitos bite. It may be that the female mosquito bites in part to offload the malaria parasite from its own body. Male mosquito sex hormones may protect against or kill the malaria parasite. This is a theory which has had the opportunity to be tested. No confirmation of this theory has occurred. Thus it may not be correct. However, it is my theory on malaria.

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
Calais School Offers Another Face of Europe’s Migrant Crisisi
X
Lisa Bryant
September 02, 2015 6:19 PM
Europe is facing mounting criticism over how it’s handling its biggest migration crisis since World War II. But not all Europeans believe building walls or passing repressive policies are the answer. A school for migrants in the French port city of Calais, is opening doors and building bonds across nationalities. VOA's Lisa Bryant reports.
Video

Video Calais School Offers Another Face of Europe’s Migrant Crisis

Europe is facing mounting criticism over how it’s handling its biggest migration crisis since World War II. But not all Europeans believe building walls or passing repressive policies are the answer. A school for migrants in the French port city of Calais, is opening doors and building bonds across nationalities. VOA's Lisa Bryant reports.
Video

Video Russia-Japan Relations Cool as Putin Visits China for WWII Anniversary

Russian President Vladimir Putin is in Beijing for commemorations of the 70th anniversary of China's WWII victory over Japan. Putin is expected to visit Japan later this year, but tensions between Tokyo and Moscow over islands disputed since the war, and sanctions over Ukraine, could pour cold water on the plan. VOA's Daniel Schearf reports.
Video

Video Kurdish Fighters on IS Frontline Ready for Offensive

Finger on the trigger, the Kurdish Peshmerga soldier stared across the dust at a village taken over by Islamic State extremists. The Kurdistan’s Khazir frontline, just 45 minutes from the Islamic State stronghold of Mosul. And at this point, the militants were less than two kilometers away. VOA's Sharon Behn reports.
Video

Video Yemen ‘on Brink of Disaster’ as Medical Shortages Soar

Aid agencies warn Yemen is on the brink of humanitarian disaster – with up to half a million children facing severe malnutrition, and hospitals running out of basic medicines. There are fears Yemen's civil war could escalate as the coalition led by Saudi Arabia tries to drive back Houthi rebels, who seized control of much of the country earlier this year. Henry Ridgwell reports.
Video

Video Apps Helping Kenyan Businesses Stay Ahead of Counterfeiters

Counterfeit goods in Kenya cost the government as much as $1 billion each year in lost tax revenues. The fake goods also hurt entrepreneurs who find it hard to carve out a niche in the market and retain customers. But as Lenny Ruvaga reports from Nairobi, information technology is being used to try to beat the problem.
Video

Video Nobel Prize Winner Malala Talks to VOA

Nobel Peace Prize winner Malala Yousafzai met with VOA's Deewa service in Washington Sunday to talk about women’s rights and unveil a trailer for her new documentary. VOA's Katherine Gypson has more.
Video

Video War, Drought Threaten Iraq's Marshlands

Iraq's southern wetlands are in crisis. These areas are the spawning ground for Gulf fisheries, a resting place for migrating wildfowl, and source of livelihood for fishermen and herders. Faith Lapidus has more.
Video

Video Colombians Flee Venezuela as Border Crisis Escalates

Hundreds of Colombians have fled Venezuela since last week, amid an escalating border crisis between the two countries. Last week, Venezuelan President Nicolas Maduro ordered the closure of a key border crossing after smugglers injured three Venezuelan soldiers and a civilian. The president also ordered the deportation of Colombians who are in Venezuela illegally. Zlatica Hoke reports.
Video

Video Rebuilding New Orleans' Music Scene

Ten years after Hurricane Katrina inundated New Orleans, threatening to wash away its vibrant musical heritage along with its neighborhoods, the beat goes on. As Bronwyn Benito and Faith Lapidus report, a Musicians' Village is preserving the city's unique sound.
Video

Video In Russia, Auto Industry in Tailspin

Industry insiders say country relies too heavily on imports as inflation cuts too many consumers out of the market. Daniel Schearf has more from Moscow.
Video

Video Scientist Calls Use of Fetal Tissue in Medical Research Essential

An anti-abortion group responsible for secret recordings of workers at a women's health care organization claims the workers shown are offering baby parts for sale, a charge the organization strongly denies. While the selling of fetal tissue is against the law in the United States, abortion and the use of donated fetal tissue for medical research are both legal. VOA’s Julie Taboh reports.
Video

Video Next to Iran, Climate at Forefront of Obama Agenda

President Barack Obama this week announced new initiatives aimed at making it easier for Americans to access renewable energy sources such as solar and wind. Obama is not slowing down when it comes to pushing through climate change measures, an issue he says is the greatest threat to the country’s national security. VOA correspondent Aru Pande has more from the White House.
Video

Video Arctic Draws International Competition for Oil

A new geopolitical “Great Game” is underway in earth’s northernmost region, the Arctic, where Russia has claimed a large area for resource development and President Barack Obama recently approved Shell Oil Company’s test-drilling project in an area under U.S. control. Greg Flakus reports.
Video

Video Philippine Maritime Police: Chinese Fishermen a Threat to Country’s Security

China and the Philippines both claim maritime rights in the South China Sea.  That includes the right to fish in those waters. Jason Strother reports on how the Philippines is catching Chinese nationals it says are illegal poachers. He has the story from Palawan province.
Video

Video China's Spratly Island Building Said to Light Up the Night 'Like A City'

Southeast Asian countries claim China has illegally seized territory in the Spratly islands. It is especially a concern for a Philippine mayor who says Beijing is occupying parts of his municipality. Jason Strother reports from the capital of Palawan province, Puerto Princesa.

VOA Blogs