News / Health

Scientists Develop Therapy That Someday Might Protect Public Against Flu Pandemics

Flu shot
Flu shot
Jessica Berman
Researchers have developed a gene therapy against pandemic influenza in laboratory animals, one that stops infection at the point of entry - the nose.  The therapy could potentially thwart the most aggressive viral pathogens, saving the lives of an estimated 500,000 people who die worldwide each year from the flu.

The genetic therapy developed by researchers at the University of Pennsylvania expresses so-called broadly neutralizing antibodies, giving lab mice and ferrets almost complete protection against a number of lethal avian influenza strains, including those isolated from the deadly 1918 and 2009 pandemics.  

Unlike conventional vaccines which stimulate the body’s natural immune system to fight an infection, broadly neutralizing antibodies halt a virus’s biological activity so it cannot make people sick by infecting cells in the first place.  The antibodies can become effective in two to three days.

The head of the University of Pennsylvania's Gene Therapy Program, James Wilson, says scientists created a nasal spray to introduce protective genes.

“And create what I call a "bioshield" around the nose and the mouth to prevent the influenza virus from replicating,” Wilson said.

The genes, which engineer the tissue to produce protective antibodies, were delivered by a harmless cold virus in the nasal spray.  

The therapy uses a single gene that produces antibodies against many different flu strains, hence the term, "broadly neutralizing antibodies."  Wilson says this broad-based strategy protected all mice exposed to lethal amounts of three strains of H5N1 and two strains of H1N1.  

But the microbes replicated or reproduced rapidly in untreated rodents.  The nasal spray was also successfully tested in ferrets, a good model for human flu because the tiny, furry animals cough and sneeze when sick.

Conventional vaccines to protect against seasonal influenza are not 100 percent effective in preventing illness.  The viral strains mutate rapidly, so there is little or no immune-system protection stimulated by the previous year’s flu shot, and the pathogens can evade experts' predictions of what virus is likely to be in circulation during the coming flu season.

Wilson says a different approach to flu protection is needed.  Researchers are currently in discussions with U.S. drug regulators about quickly testing the therapy in humans using a safe flu strain.  According to Wilson, they are aiming to manufacture and stockpile the drug in anticipation of a serious influenza pandemic.

“So then there is a pretty direct path into first, in human safety and then efficacy studies, which we have charted out.  And with the right resources, we could move very quickly on that,” Wilson said.

Wilson says the U.S. government has also expressed an interest in using the broadly neutralizing antibody approach to protect against bioweapons, such as anthrax and other toxic agents.

An article on the development of a gene therapy against pandemic influenza is published in Science Translational Medicine.

You May Like

As US Strikes Syria, China Sees Parallels at Home

Beijing is debating how much support to give international coalition against IS militants and trying to figure out how many Chinese nationals may have joined group overseas More

CDC: Ebola Could Infect 1.4 Million by January

US health officials say if efforts to curb the outbreak are not increased, cases will soar dramatically by early next year More

Video USAID Provides $231 Million for Girls Education in 5 Countries

US Agency for International Development partners with celebrities to call attention to importance of education for girls worldwide More

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
NASA’s MAVEN Probe Enters Mars Orbiti
X
September 22, 2014 9:20 PM
NASA’s newest Mars probe, called MAVEN, has successfully entered its designated orbit around the Red Planet. Scientists will use its sophisticated instruments to try to learn what happened to the atmosphere Mars had a few billion years ago. VOA’s George Putic has more.
Video

Video NASA’s MAVEN Probe Enters Mars Orbit

NASA’s newest Mars probe, called MAVEN, has successfully entered its designated orbit around the Red Planet. Scientists will use its sophisticated instruments to try to learn what happened to the atmosphere Mars had a few billion years ago. VOA’s George Putic has more.
Video

Video For West Ukraine City, Conflict Far Away Yet Near

The western Ukrainian city of Lviv prides itself on being both physically and culturally close to Western Europe. The Russian-backed separatists in the eastern part of the country are 1,200 kilometers away, and seemingly even farther away in their world view. Still, as VOA’s Al Pessin reports, the war is having an impact in Lviv.
Video

Video Saving Global Fish Stocks Starts in the Kitchen

With an estimated 90 percent of the world’s larger fish populations having already vanished, a growing number of people in the seafood industry are embracing the concept of sustainable fishing and farming practices. One American marine biologist turned restaurateur in Thailand is spreading the word among fellow chefs and customers. VOA Correspondent Steve Herman reports from Bangkok.
Video

Video Chinese Admiral Key in China’s Promotion of Sea Links

China’s President last week wrapped up landmark visits to India, Sri Lanka and Maldives, part of a broader campaign to promote a new “Maritime Silk Road” in Asia. The Chinese government’s promotion efforts rely heavily on the country’s best-known sailor, a 15th century eunuch named Zheng He. VOA's Bill Ide reports from the sailor’s hometown in Yunnan on the effort to promote China’s future by recalling its past.
Video

Video Experts Fear Ebola Outbreak ‘Beyond Our Capability to Contain’

Each day brings with it new warnings about the deadly Ebola outbreak already blamed for killing more than 2,600 people across West Africa. And while countries and international organizations like the United Nations are starting to come through on promises of help for those most affected, the unprecedented speed with which the virus has spread is raising questions about the international response. VOA's Jeff Seldin has more from Washington.
Video

Video Natural Gas Export Plan Divides Maryland Town

A U.S. power company that has been importing natural gas now wants to export it. If approved, its plant in Lusby, Maryland, would likely be the first terminal on the United States East Coast to export liquefied natural gas from American pipelines. While some residents welcome the move because it will create jobs, others oppose it, saying the expansion could be a safety and environmental hazard. VOA’s Deborah Block examines the controversy.
Video

Video Difficult Tactical Battle Ahead Against IS Militants in Syria

The U.S. president has ordered the military to intensify its fight against the Islamic State, including in Syria. But how does the military conduct air strikes in a country that is not a U.S. ally? VOA correspondent Carla Babb reports from the Pentagon.
Video

Video Iran, World Powers Seek Progress in Nuclear Talks

Iran and the five permanent members of the U.N. Security Council plus Germany, known as the P5 + 1, have started a new round of talks on Iran's nuclear program. VOA State Department correspondent Pam Dockins reports that as the negotiations take place in New York, a U.S. envoy is questioning Iran's commitment to peaceful nuclear activity.
Video

Video Migrants Caught in No-Man's Land Called Calais

The deaths of hundreds of migrants in the Mediterranean this week has only recast the spotlight on the perils of reaching Europe. And for those forunate enough to reach a place like Calais, France, only find that their problems aren't over. Lisa Bryant has the story.
Video

Video Westgate Siege Anniversary Brings Back Painful Memories

One year after it happened, the survivors of the terror attack on Nairobi's Westgate Shopping Mall still cannot shake the images of that tragic incident. For VOA, Mohammed Yusuf tells the story of victims still waiting for the answer to the question 'how could this happen?'
Video

Video Whaling Summit Votes to Uphold Ban on Japan Whale Hunt

The International Whaling Commission, meeting in Slovenia, has voted to uphold a court ruling banning Japan from hunting whales in the Antarctic Ocean. Conservationists hailed the ruling as a victory, but Tokyo says it will submit revised plans for a whale hunt in 2015. Henry Ridgwell reports from London.
Video

Video A Dinosaur Fit for Land and Water

Residents and tourists in Washington D.C. can now examine a life-size replica of an unusual dinosaur that lived almost a hundred million years ago in northern Africa. Scientists say studying the behemoth named Spinosaurus helps them better understand how some prehistoric animals adapted to life on land and in water. The Spinosaurus replica is on display at the National Geographic museum. VOA’s George Putic has more.
Colonel Steve ‘Spiros’ Pisanos left Greece and came to the U.S. to learn to fly. He flew fighters for the Allies in World War II, narrowly escaping death multiple times.Colonel Steve ‘Spiros’ Pisanos left Greece and came to the U.S. to learn to fly. He flew fighters for the Allies in World War II, narrowly escaping death multiple times.

AppleAndroid