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Cockroaches Could Lead to New Antibiotics

The female emerald cockroach wasp leads her prey by the antenna after stinging it to render it docile. The egg she lays on the roach will hatch, burrow inside, and feed on the roach as the wasp larva develops. (Courtesy Gudrun Herzner)
The female emerald cockroach wasp leads her prey by the antenna after stinging it to render it docile. The egg she lays on the roach will hatch, burrow inside, and feed on the roach as the wasp larva develops. (Courtesy Gudrun Herzner)
Most people might see cockroaches as good-for-nothing pests, but this germ-ridden insect could be an indirect source of new antibiotics for humans.

Cockroaches host the larvae of a parasitic type of wasp, which spend their formative days eating the bacteria-laden body of the cockroach from the inside out.

Researchers have discovered the wasp larva secretes chemicals that sanitize the decidedly unsanitary guts of the cockroach.

These germ-killing chemicals could eventually be developed for human uses.

Cockroach cradle

For the developing larvae, “the cockroach is the only food source and the cradle,” says biologist Gudrun Herzner at the University of Regensburg in Germany.

It’s a cradle that needs a good cleaning, because cockroaches spend time in some very unsanitary places, from trash heaps to public toilets, where you’ll find a cornucopia of bacteria, fungi and viruses that can make you, and the emerald wasp larva, sick.

While the young wasp’s hygiene challenges may seem extreme, Herzner says they are basically the same problems we all face. “The larva has to protect, first, its food from degradation by microbes, and then it has to protect itself from foodborne illnesses that these microbes might cause.”

Sanitizer dispenser

As the wasp larva munches its way through the microbe-laden body of the cockroach, it produces generous amounts of a clear liquid.

Herzner and her colleagues found this liquid to contain a blend of antimicrobial substances, according to their study published in the Proceedings of the National Academy of Sciences.

"The larvae seem to disperse this secretion thoroughly inside the cockroach, and in this way sanitize their cockroach hosts,” Herzner says.

One of the chemicals fights the germs that cause tuberculosis; another has a broad range of activity against bacteria, fungi, and viruses such as hepatitis C.

Herzner says it is the first time researchers have found insects using this chemical against microbes.

Insect drugs

But it’s probably not the last insect antimicrobial discovery.

Most antibiotics that doctors use have been discovered among microbes living in the soil, but if researchers turn to the insect world, microbiologist Julian Davies, at the University of British Columbia, says, “You can have a potentially new source of antibiotics. People have been looking at this. Nothing’s come out of it yet, but they’re certainly looking at it.”

Antimicrobials have been discovered everywhere from frog skin to panda blood, but none of them have made it to the medicine cabinet yet.

Davies says it can be hard to isolate useful quantities of the active chemicals in these sources, and they may be difficult chemicals to produce in the lab.

Plus, Davies says, “It’s fine to find an antibiotic, but half of them are toxic.”

Scientists are working to overcome these hurdles.

Bacteria talking?

Davies says these chemicals may be more than just microbe killers. He points to the emerging field of research on microbe-to-microbe chemical communication.

“And you can ask the question, ‘Are they killing each other, or are they talking to each other?’”

But, with antibiotic-resistant infections a growing threat worldwide, killing the microbes is scientists' current priority.

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