News / Health

Human Ebola Vaccine Trials to Begin

Ebola Vaccine Trials To Begin Next Weeki
X
August 29, 2014 2:18 AM
The National Institutes of Health says it is launching early stage trials of a vaccine to prevent the Ebola virus, which has infected or killed thousands of people across West Africa. The World Health Organization says Ebola could infect more than 20,000 people across the region by the time the outbreak is over. The epidemic has health experts and governments scrambling to prevent more people from becoming infected. Zlatica Hoke has more.
Watch related video report from VOA's Zlatica Hoke.
Joe DeCapua

U.S. health officials announced Thursday the launch of the first human testing of a vaccine to prevent Ebola. The vaccine candidate was co-developed by the National Institute of Allergy and Infectious Diseases - and the pharmaceutical company GSK (GlaxoSmithKline).

Dr. Anthony Fauci says vaccine research has accelerated since the Ebola epidemic was first reported in West Africa last March.

"We are announcing the opening of a small human safety study of an investigational Ebola vaccine candidate that will be tested here at the NIH," he said. "This is the first of several Phase One clinical trials of Ebola vaccine candidates that we are set to launch."

Fauci is the head of the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. He describes the West Africa Ebola outbreak as a “public health emergency that demands an all hands on deck response.”

"We have accelerated the time line for testing experimental Ebola vaccines that we have been developing for several years," he said. "And after an expedited review of the candidate product and clinical trial design by the United States Food and Drug Administration we have the green light to begin."

He says the trials will be based on three earlier versions of Ebola vaccine candidates. Those trials led to the vaccine that is now being studied. Next week, the first three volunteers will be enrolled in a study known as VRC207.

"The trial aims to enroll 20 healthy adults - ages 18 to 50 years - at the NIH Clinical Research Center here in Bethesda, Maryland," he said. "The study will evaluate the experimental vaccine’s safety and whether it generates an immune response in healthy adults that - based on our animal studies - could predict effectiveness in preventing the acquisition of Ebola infection."

Fauci says earlier studies of the experimental vaccine performed extremely well in protecting primates from Ebola infection.  The current vaccine candidate uses a chimpanzee cold virus. The virus carries a gene related to the surface protein of the Zaire and Sudan strains of the Ebola virus. The Zaire strain is blamed for the West Africa epidemic.

"It is important to know that the Ebola gene contained in the investigational vaccine cannot cause a vaccinated individual to become infected with Ebola," he said. "The volunteers in the VRC207 trial will be divided into two groups to test first a lower and then a higher does of the vaccine.

The vaccine will be administered through an injection in the arm. The trial is scheduled to last 48 weeks, but initial findings could be available by the end of this year.  

In October, a second trial will begin in the U.S., Britain, Mali and The Gambia to test a vaccine candidate that contains genetic material from only one of the Ebola strains.

Fauci says despite the vaccine research, precaution and prevention are the best defense right now against the disease.

You May Like

Will Cuba Follow the Southeast Asia Model?

Decision to restore ties between US and Cuba has some debating whether it will lead to enhancement or regression of democracy for Communist island nation More

Kenyan Designer Finds Her Niche in Fashion Industry

‘Made in China’ fabrics underlie her success More

Report: CIA, Israel's Mossad Killed Senior Hezbollah Commander

The Washington Post story says Imad Mughniyah was killed instantly by a bomb "triggered remotely" from Tel Aviv by Mossad agents More

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
Jefferson's Library Continues to Impress, 200 Years Lateri
X
Deborah Block
January 31, 2015 12:12 AM
Two hundred years after the U.S. Congress purchased a huge collection of books belonging to former President Thomas Jefferson, it remains one of America’s greatest literal treasures and has become the centerpiece of Washington’s Library of Congress. VOA’s Deborah Block reports.
Video

Video Jefferson's Library Continues to Impress, 200 Years Later

Two hundred years after the U.S. Congress purchased a huge collection of books belonging to former President Thomas Jefferson, it remains one of America’s greatest literal treasures and has become the centerpiece of Washington’s Library of Congress. VOA’s Deborah Block reports.
Video

Video Egypt's Suez Canal Dreams Tempered by Continued Unrest

Egypt plans to expand the Suez Canal, raising hopes that the end of its economic crisis may be in sight. But some analysts say they expect the project may cost too much and take too long to make life better for everyday Egyptians. VOA's Heather Murdock reports.
Video

Video Threat of Creeping Lava Has Hawaiians on Edge

Residents of the small town of Pahoa on the Big Island of Hawaii face an advancing threat from the Kilauea volcano. Local residents are keeping a watchful eye on creeping lava. Mike O’Sullivan reports.
Video

Video Pro-Kremlin Youth Group Creatively Promotes 'Patriotic' Propaganda

As Russia's President Vladimir Putin faces international pressure over Ukraine and a failing economy, unofficial domestic groups are rallying to his support. One such youth organization, CET, or Network, uses creative multimedia to appeal to Russia's urban youth with patriotic propaganda. VOA's Daniel Schearf reports.
Video

Video Filmmakers Produce Hand-Painted Documentary on Van Gogh

The troubled life of the famous 19th century Dutch painter Vincent van Gogh has been told through many books and films, but never in the way a group of filmmakers now intends to do. "Loving Vincent " will be the first ever feature-length film made of animated hand-painted images, done in the style of the late artist. VOA’s George Putic reports.
Video

Video Issues or Ethnicity? Question Divides Nigeria

As Nigeria goes to the polls next month, many expect the two top presidential contenders to gain much of their support from constituencies organized along ethnic or religious lines. But are faith and regional blocs really what political power in Nigeria is about? Chris Stein reports.
Video

Video Rock-Consuming Organisms Alter Views of Life Processes

Scientists thought they knew much about how life works, until a discovery more than two decades ago challenged conventional beliefs. Scientists found that there are organisms that breathe rocks. And it is only recently that the scientific community is accepting that there are organisms that could get energy out of rocks. Correspondent Elizabeth Lee reports.
Video

Video Paris Attacks Highlight Global Weapons Black Market

As law enforcement officials piece together how the Paris and Belgian terror cells carried out their recent attacks, questions are being asked about how they obtained military grade assault weapons - which are illegal in the European Union. As VOA's Jeff Swicord reports, experts say there is a very active worldwide black market for these weapons, and criminals and terrorists are buying.
Video

Video Activists Accuse China of Targeting Religious Freedom

The U.S.-based Chinese religious rights group ChinaAid says 2014 was the worst year for religious freedom in China since the end of the Cultural Revolution. As Ye Fan reports, activists say Beijing has been tightening religious controls ever since Chinese leader Xi Jinping came to office. Hu Wei narrates.
Video

Video Theologians Cast Doubt on Morality of Drone Strikes

In 2006, stirred by photos of U.S. soldiers mistreating Iraqi prisoners, a group of American faith leaders and academics launched the National Religious Campaign Against Torture. It played an important role in getting Congress to investigate, and the president to ban, torture. VOA's Jerome Socolovsky reports.
Video

Video Former Sudan 'Lost Boy' Becomes Chess Master in NYC

In the mid-1980’s, thousands of Sudanese boys escaped the country's civil war by walking for weeks, then months and finally for more than a year, up to 1,500 kilometers across three countries. The so-called Lost Boys of the Sudan had little time for games. But one of them later mastered the game of chess, and now teaches it to children in the New York area. VOA’s Bernard Shusman in New York has his story.
Video

Video NASA Monitors Earth’s Vital Signs From Space

The U.S. space agency, NASA, is wrapping up its busiest 12-month period in more than a decade, with three missions launched in 2014 and two this month, one in early January and the fifth scheduled for January 29. As VOA’s Rosanne Skirble reports, the instruments being lifted into orbit are focused on Earth’s vital life support systems and how they are responding to a warmer planet.

Circumventing Censorship

An Internet Primer for Healthy Web Habits

As surveillance and censoring technologies advance, so, too, do new tools for your computer or mobile device that help protect your privacy and break through Internet censorship.
More

All About America

AppleAndroid