News / Health

    Interspecies Transplant Paves the Way for Diabetes Therapy

    Jessica Berman
    Researchers have come closer to the “Holy Grail” of treatment for people with type 1 diabetes. They have successfully transplanted insulin-producing islet cells from one species into another without the use of immunity-suppressing drugs. In the future this could provide an unlimited supply of tissue to treat people whose bodies cannot produce insulin.

    Insulin is a hormone produced by the pancreas that delivers glucose - a form of sugar that the body uses for fuel - to cells for energy. Since the immune systems of people with type 1 diabetes attack and destroy the islet cells that produce insulin, many sufferers must inject themselves with insulin frequently, simply in order to survive.

    It has long been a goal of scientists to transplant islets into humans - from other humans or pigs - without their bodies rejecting them. Human cadaver transplants are difficult, while animal-to-human transplants have proved nearly impossible.

    Now, investigators at Northwestern University in Illinois have carried out a successful interspecies islet cell transplant, from rats into mice, without the lifelong use of anti-rejection medications, which carry significant side effects and risks, including cancer.

    The study's lead author, Xunrong Luo, head of the Northwestern medical school's human islet cell transplantation program, said the transplanted rat cells produced insulin in the mice for more than 300 days.

    “They survived essentially indefinitely. So they continued to produce insulin without the need of any immunosuppression and [the cells] just continued to maintain normal glucose levels in these diabetic mice,” she said.

    The mice were prepared for transplant by taking white blood cells from a rat’s spleen, which is part of the immune system, and bathing them in chemicals that put the cells into a sleeping state known as programmed cell death.  

    The altered cells were injected into mice. They entered the rodents’ spleen and liver but were soon mopped up [gathered, and destroyed ] by scavenger cells called macrophages, which recognized the sleeping rat cells as waste. In that process, fragments of the rat spleen cells wound up on the surface of the macrophages. This "trained" [conditioned] the mouse's immune-system T cells to accept islet cells, which researchers successfully transplanted seven days later.

    “So we are pretty excited about that, because our next step is to see if we can translate this into [a] larger step, into larger animals,” she said.

    Luo says her team now will try to transplant pig cells into monkeys. Her ultimate goal is to be able to tap into an unlimited supply of pig islet cells for transplants into people with type 1 diabetes.  

    An article on interspecies transplants of insulin-producing islet cells appears in the journal Diabetes.

    You May Like

    US Internet Giants, EU Reach Deal to Combat Online Hate Speech

    Facebook, Twitter, Google and Microsoft commit to ‘quickly and efficiently’ act to clamp down on use of social media to incite violence, terror

    Video Tunisia’s Ennahda Party Begins a New Political Chapter

    Party now moves to separate its political and religious activities; change described by party members as pragmatic response to political and economic challenges facing Tunisia today

    Virtual Reality Fine-tuned at Asia Tech Show

    Microchip designers hope to improve resolution for users of systems that can turn your bedroom into the ocean floor

    Featured Videos

    Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
    Tech Startups Showcase Wares at Amsterdam Conferencei
    X
    Serginho Roosblad
    May 30, 2016 5:11 PM
    More than 20,000 tech enthusiasts, entrepreneurs and lovers of digital technology came together in Amsterdam recently at the Next Web Conference to discuss the latest developments in digital technology, look to the future and, of course, to connect. In recent years, there has been an explosion of so-called startup businesses that have created devices and applications that have changed the way we live; but, as Serginho Roosblad reports for VOA, there are pitfalls for such startups as well.
    Video

    Video Tech Startups Showcase Wares at Amsterdam Conference

    More than 20,000 tech enthusiasts, entrepreneurs and lovers of digital technology came together in Amsterdam recently at the Next Web Conference to discuss the latest developments in digital technology, look to the future and, of course, to connect. In recent years, there has been an explosion of so-called startup businesses that have created devices and applications that have changed the way we live; but, as Serginho Roosblad reports for VOA, there are pitfalls for such startups as well.
    Video

    Video US Military's Fallen Honored With Flags

    Memorial Day is a long weekend for most Americans. For some, it is the unofficial start of summer -- local swimming pools open and outdoor grilling season begins. But Memorial Day remains true to its origins -- a day to remember the U.S. military's fallen.
    Video

    Video Rolling Thunder Rolls Into Washington

    The Rolling Thunder caravan of motorcycles rolled into Washington Sunday, to support the U.S. military on the country's Memorial Day weekend
    Video

    Video A New Reading Program Pairs Kids with Dogs

    Dogs, it is said, are man's best friend. What some researchers have discovered is that they can also be a friend to a struggling reader. A group called Intermountain Therapy Animals trains dogs to help all kinds of kids with reading problems — from those with special needs to those for whom English is a second language. Faiza Elmasry has more on the New York chapter of R.E.A.D., or Reading Education Assistance Dogs, in this piece narrated by Faith Lapidus.
    Video

    Video Fan Base Grows for Fictional Wyoming Sheriff Longmire

    Around the world, the most enduring symbol of the U.S. is that of the cowboy. A very small percentage of Americans live in Western rural areas, and fewer still are cowboys. But the fascination with the American West is kept alive by such cultural offerings as “Longmire,” a series of books and TV episodes about a fictional Wyoming sheriff. VOA’s Greg Flakus recently spoke with Longmire’s creator, Craig Johnson, and filed this report from Houston.
    Video

    Video Chinese-Americans Heart Trump, Bucking National Trend

    A new study conducted by three Asian-American organizations shows there are three times as many Democrats as there are Republicans among Asian-American voters, and they favor Hillary Clinton over Donald Trump. But one group, called Chinese-Americans For Trump, is going against the tide and strongly supports the business tycoon. VOA’s Elizabeth Lee caught up with them at a Trump rally and reports from Anaheim, California.
    Video

    Video Reactions to Trump's Success Polarized Abroad

    What seemed impossible less than a year ago is now almost a certainty. New York real estate mogul Donald Trump has won the number of delegates needed to secure the Republican presidential nomination. The prospect has sparked as much controversy abroad as it has in the United States. Zlatica Hoke has more.
    Video

    Video Drawings by Children in Hiroshima Show Hope and Peace

    On Friday, President Barack Obama will visit Hiroshima, Japan, the first American president to do so while in office. In August 1945, the United States dropped an atomic bomb on the city to force Japan's surrender in World War II. Although their city lay in ruins, some Hiroshima schoolchildren drew pictures of hope and peace. The former students and their drawings are now part of a documentary called “Pictures from a Hiroshima Schoolyard.” VOA's Deborah Block has the story.
    Video

    Video Vietnamese Rapper Performs for Obama

    A prominent young Vietnamese artist told President Obama said she faced roadblocks as a woman rapper, and asked the president about government support for the arts. He asked her to rap, and he even offered to provide a base beat for her. Watch what happened.
    Video

    Video Roots Run Deep for Tunisia's Dwindling Jewish Community

    This week, hundreds of Jewish pilgrims are defying terrorist threats to celebrate an ancient religious festival on the Tunisian island of Djerba. The festivities cast a spotlight on North Africa's once-vibrant Jewish population that has all but died out in recent decades. Despite rising threats of militant Islam and the country's battered economy, one of the Arab world's last Jewish communities is staying put and nurturing a new generation. VOA’s Lisa Bryant reports.

    Special Report

    Adrift The Invisible African Diaspora