News / Health

Mount Everest Climb Exposes Diabetes Mechanism - Study

FILE - A team of mountaineers is seen climbing Mount Everest.
FILE - A team of mountaineers is seen climbing Mount Everest.
Jessica Berman
Using the world's highest mountain, Mount Everest, as an outdoor laboratory, a group of British researchers has identified a mechanism involved in the development of adult onset diabetes.  Experts say the findings could lead to development of treatments to prevent the disease.

At more than 8,800 meters above sea level, Mount Everest in Nepal is the world’s highest peak.  Climbers require supplemental oxygen because the air is so thin. 
Hypoxia, or lack of blood oxygen, is a risk factor for the onset of Type 2 diabetes. 

So, researchers with the Mount Everest project sought to identify the mechanisms by which low oxygen levels contribute to disease in patients who are critically ill with diabetes.

Mike Grocott, a professor of anesthesia and critical care medicine at Southampton University, led the study, which began at an Everest base camp 5,300 meters above sea level.

The expedition included about 200 climbers.  But Grocott says researchers focused on 24 individuals who underwent assessments of glucose control, body weight changes and inflammation biomarkers.  The measurements were taken at six weeks and again at two months.  Eight climbers then continued their trek to the peak.

In the low oxygen environment, Grocott says the participants' insulin levels began to rise, indicating their bodies were becoming insulin resistant.

There also was an increase in biomarkers of inflammation and oxidative stress, or cellular damage, similar to what’s seen in people with Type 2 diabetes.

On the ground, Grocott says the findings suggest treatments might be developed to prevent the disease.

“Helping to control the tendency towards diabetes may be interventions that are focusing on either the development of this oxidative stress or this inflammation,” says Grocott.

In an article published in the journal PLoS ONE, investigators report the abnormal biomarkers, caused by the extreme altitude, were reversed once the participants came off the mountain.

Many people who develop diabetes suffer from sleep apnea, in which their airways become obstructed - sometimes hundreds of times per night. 

“That is likely to predispose them to certainly intermittent hypoxia during sleep.  And that may be something that is contributing toward this tendency to develop Type 2 diabetes,” says Grocott.

Grocott says investigators are now comparing the climbers, most of whom were Caucasian, to the Sherpa to see whether genetic differences protect the indigenous Nepalese population from diabetes.

You May Like

Video VOA Reporter Tours Devastated Peshawar School

Islamist militants wearing military uniforms and strapped with explosives attacked a military run school Tuesday in the northwestern Pakistani city of Peshawar. At least 141 people were killed in the horrific attack, most of them young students. More

Video Sudan School Becomes Target of Aerial Attacks

Dropout rate at an all-time high in South Kordofan state because many schools have been destroyed during 3-year civil war More

Tennessee Songbirds Fly Coop Long Before Tornadoes Arrive

Researchers say birds apparently alerted to danger by sounds at frequencies below range of human hearing More

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
US: Response to Sony Hack Will Be Proportionali
X
Aru Pande
December 19, 2014 1:45 AM
The White House says President Barack Obama considers the cyberattack on Sony Corp. a serious national security matter and that the U.S. will counter with an "appropriate response." VOA correspondent Aru Pande reports.
Video

Video US: Response to Sony Hack Will Be Proportional

The White House says President Barack Obama considers the cyberattack on Sony Corp. a serious national security matter and that the U.S. will counter with an "appropriate response." VOA correspondent Aru Pande reports.
Video

Video Sudan School Becomes Target of Aerial Attacks

The school dropout rate is at an all-time high in Sudan's South Kordofan state because many schools have been destroyed during the three-year civil war between the government and SPLA-N rebel forces. Adam Bailes visited Sudan's Nuba Mountains' region and reports many children are simply too scared to go to school
Video

Video Nigerians Fleeing Boko Haram Languish in Camp Near Capital

In its five-year effort to impose Islamic law in northeastern Nigeria, the Boko Haram extremist group has killed thousands of people and forced hundreds of thousands to flee. Some of those who ran for their lives now live in squalor on the edges of the capital, Abuja. Chris Stein reports for VOA.
Video

Video Putin Says Russian Economy Will Emerge Stronger

Russian President Vladimir Putin has said his country's sinking economy will not only recover but also become stronger, despite falling oil prices and Western sanctions over Ukraine. VOA's Daniel Schearf reports.
Video

Video Detained Turkish Journalists Follow Teachings of US-Based Preacher

The Turkish government’s jailing of critical journalists has sparked international condemnation and is being seen as an effort to undermine the followers of an ailing Turkish preacher based in the United States. VOA religion reporter Jerome Socolovsky has more.
Video

Video ‘Anti-Islamization’ Marches Increase Tensions In Germany

Anti-immigrant rallies in Germany have been building in recent weeks, peaking Monday night in the city of Dresden where tens of thousands of people turned out to demonstrate against what they call the ‘Islamization’ of the West. Germany has offered asylum to more Syrian refugees than any other country, and this appears to have set off the protests. Henry Ridgwell reports from London.
Video

Video Aceh Rebuilt Decade After Tsunami, But Scars Remain

On December 26, 2004 there was an earthquake in the Indian Ocean so powerful it caused the Earth’s axis to wobble a few centimeters. Onshore on the island of Sumatra, the resulting tsunami was devastating. A decade later, VOA Correspondent Steve Herman reports from Banda Aceh, Indonesia, where although there is little remaining evidence of the physical devastation, the psychological scars among survivors remain.
Video

Video Refugees Living in Kenya Long for Peace in the Home Countries

Kenya is host to numerous refugees seeking safe haven from conflict. Immigrants from Somalia face challenges in their new lives in Kenya. Ahead of International Migrants Day (December 18) Lenny Ruvaga has more for VOA News from the Kenyan capital.

All About America

AppleAndroid