Pope Francis is scheduled to meet Monday with Israeli Prime Minister Benjamin Netanyahu and President Shimon Peres. He will also visit Israel's national cemetery, Mount Herzl, and the Yad Vashem Holocaust memorial.
In a welcome ceremony with the Israeli leaders, the pope said, "The right of the state of Israel to exist and to flourish in peace and security within internationally recognized borders must be universally recognized.”
Earlier Monday, the leader of the world's 1.3 billion Roman Catholics will meet with the Grand Mufti of Jerusalem, Muhammad Ahmad Hussein, at the al-Aqsa mosque complex in Jerusalem's Old City, and visit the Dome of the Rock. The mosque compound is built on Judaism's holiest site where the biblical First and Second Temples are believed to have stood. The compound is considered the third holiest site in Islam.
Monday is the last day of the pope's three-day Middle Eastern visit.
On Sunday, Israeli President Peres and Palestinian President Mahmoud Abbas accepted Pope Francis' invitation to come to the Vatican and pray for peace with him.
Speaking in the West Bank town of Bethlehem, Francis said the time has come "for everyone to find the courage to be generous and creative" in ending "a protracted conflict that has inflicted many wounds."
The pope presided Sunday over a joint prayer service with Orthodox Ecumenical Patriarch Bartholomew at the Church of the Holy Sepulcher in Jerusalem, the site where Christians believe Jesus was crucified and buried.
Francis also celebrated Mass at Bethlehem's Manger Square, near the site where Christians believe Jesus was born, before meeting with Palestinian children in Deheisheh Refugee Camp.
Saturday, in Jordan, Francis held talks with King Abdullah and heard first-hand accounts of the suffering of refugees who have fled Iraq and Syria for the safety of makeshift encampments in Jordan.
Previous popes have always gone to the West Bank after first arriving in Tel Aviv, Israel. Francis' itinerary is being viewed as a symbolic nod to Palestinian aspirations for their own state.
The papal visit comes just weeks after the latest round of Israeli-Palestinian peace talks collapsed, with the Israelis accusing Abbas of sabotaging the talks by agreeing to a unity deal with Hamas Islamists who run the Gaza Strip.
Pope Francis (C) leads an open-air mass at Manger Square in the West Bank town of Bethlehem, May 25, 2014. Pope Francis made an impassioned plea for peace on a pilgrimage on Sunday to Bethlehem, the traditional birthplace of Jesus, urging an intensified effort to end the Israeli-Palestinian conflict.
Pope Francis reaches to a girl after a mass in Bethlehem.
Nuns read the ceremony booklet as they wait for the arrival of Pope Francis to celebrate Mass in Manger Square next to the Church of the Nativity in the West Bank town of Bethlehem.
Palestinians hold pictures of Pope Francis and Palestinian prisoners during a demonstration to call for the release of prisoners from Israeli jails and to support prisoners who have been on hunger strike, in the West Bank town of Nablus.
Pope Francis, center on a vehicle, greets people as he arrives in Bethlehem, West Bank.
Palestinian President Mahmoud Abbas (C) attends an open-air mass led by Pope Francis in the Manger Square, next to the Nativity Church in the West Bank town of Bethlehem.
Pope Francis touches the wall that divides Israel from the West Bank.
Pope Francis is welcomed by Palestinian President Mahmoud Abbas upon his arrival to the West Bank city of Bethlehem.
Pope Francis waves to the crowd at Manger Square in the West Bank town of Bethlehem.
In the West Bank, Francis hailed the good relations between the Holy See and Palestine. Palestinian President Abbas said he told the pope Sunday that Israel is forcing Christians and Muslims out of Jerusalem.
In its official program, the Vatican referred to Palestinian President Abbas as the president of the "state of Palestine," and his Bethlehem office as the "presidential palace."
Both Israelis and Palestinians have been trying to harness the Pope's standing as leader of the world's Roman Catholics to bolster their dueling narratives.
Some information for this report provided by Reuters and AP.