News / Health

Researchers Re-Create Eggs to Treat Infertility

For years Jim and Teresa Pica-LeRuo have been trying to have a child. They attempted several infertility regimens, including intrauterine insemination, and once became pregnant before complications caused her to lose the child, Sept. 16, 2005.
For years Jim and Teresa Pica-LeRuo have been trying to have a child. They attempted several infertility regimens, including intrauterine insemination, and once became pregnant before complications caused her to lose the child, Sept. 16, 2005.
Jessica Berman
Researchers working with laboratory rats have developed a technique that could someday help infertile women who lack usable eggs because of a hormone imbalance to conceive with new eggs created from their own ovaries.

Many women are unable to conceive because of a condition known as polycystic ovary syndrome, in which the ovaries fail to secrete enough hormones to stimulate egg production.  Injury to the ovaries caused by radiation or surgery also can interfere with a woman’s ability to produce enough viable eggs, or oocytes, to achieve pregnancy.

Anthony Atala is director of the Wake Forest Institute of Regenerative Medicine in Winston-Salem, North Carolina.  Atala says polycystic ovary disease is also commonly seen in older, pre-menopausal women. “What happens is as people get older, the fertility potential goes down and it goes down substantially.  In fact, after age 30 it drops off markedly.  And after age 40, it is very hard to get pregnant and it has to do with the egg quality that’s present in the ovaries,” he explained.

An estimated 10 percent of women struggle to become pregnant for at least a year.  After that time, they are considered to be infertile.

Atala and his research colleagues stimulated the production of immature eggs from rat ovary cells.  Atala says the cells are the equivalent of those in a 25-year-old woman.

They bathed the cells for one week in a petri dish filled with a nutrient-rich culture of chemical growth factors, and then placed the cells beneath a gel cover that allowed the cells to grow three-dimensionally instead of in a single layer.  After three weeks, scientists tested the immature eggs - which were protruding from clusters of ovarian cells -- for growth, hormone production and their ability to express genes.  

Atala says the young eggs produced hormones seen in normal, early-stage oocytes. "Our work is still in its very early stages," he said. "But it does really show that in fact cells be obtained and eggs can be developed.  And they can be matured at least up to a certain point.”

Atala says the next step is to try to coax viable eggs from human ovarian cells.  Atala envisions employing  in vitro fertilization techniques, which would use the father's sperm to artificially fertilize the newly created oocyte outside the womb.  The fertilized egg would then be returned to the mother's uterus for a normal gestation.

Atala presented the findings at the recent 2012 meeting of the American College of Surgeons' Clinical Congress.

You May Like

Is Air Travel Safe?

Aviation expert says despite tragic losses of Malaysian Airlines flights 370 and 17, industry experienced lowest fatality rate in recorded history last year More

Multimedia 100 Days Later, Nigerian Girls Still Held

Activists holding rallies in Nigeria and several other countries to mark 100th day of captivity for more than 200 schoolgirls being held by Boko Haram More

Chocolate Too Bitter? Swap Sugar for Mushrooms

US food technology company develops fermentation process using mushrooms to reduce bitterness in cocoa beans, believes it will cut sugar content in candy More

This forum has been closed.
Comment Sorting
Comments
     
by: Hilyah from: QEkPgaFJqDg
October 24, 2012 2:09 PM
Thanks for sharnig. Your post is a useful contribution.


by: Asley from: usa
October 11, 2012 12:10 PM
My sister had a problem with infertility too.She wanted to have a child with her husband she just couldn't do it.
I felt so bad for her. I mean, I love her and I read online that there are natural solutions to it. So I took it upon myself and started digging.
I FINALLY found something that looked interesting. It's a product called "Pregnancy Miracle". Long story short....my girlfriend actually ended up purchasing this product and lets just say this...
She has been successful with it and has a new born healthy baby! Amazing right? She loved the product. Anyway you can find it and the reviews at www.reviewsphere.com

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
US Carriers Suspend Travel to Israeli
X
Carolyn Presutti
July 23, 2014 1:21 AM
The United States is prohibiting American carriers from flying to Israel's airport in Tel Aviv for 24 hours, because of rising violence between Israel and Hamas militants. The action was announced on Tuesday, after a rocket fired by Hamas militants in the Gaza Strip landed near the airport. As VOA's Carolyn Presutti tells us, international officials soon may have to determine which combat zones are too dangerous for commercial flights.
Video

Video US Carriers Suspend Travel to Israel

The United States is prohibiting American carriers from flying to Israel's airport in Tel Aviv for 24 hours, because of rising violence between Israel and Hamas militants. The action was announced on Tuesday, after a rocket fired by Hamas militants in the Gaza Strip landed near the airport. As VOA's Carolyn Presutti tells us, international officials soon may have to determine which combat zones are too dangerous for commercial flights.
Video

Video NASA Focuses on Earth-Like Planets

For decades, looking for life elsewhere in the universe meant listening for signals that could be from distant civilizations. But recent breakthroughs in space technology refocused some of that effort toward finding planets that may harbor life, even in its primitive form. VOA’s George Putic reports on a recent panel discussion at NASA’s headquarters, in Washington.
Video

Video IAEA: Iran Turns its Enriched Uranium Into Less Harmful Form

Iran has converted its stockpiles of enriched uranium into a less dangerous form that is more difficult to use for nuclear weapons, according to the United Nations’ Atomic Energy Agency. The move complies with an interim deal reached with Western powers on Iran's nuclear program last year, in exchange for easing of sanctions. Henry Ridgwell reports for VOA from London.
Video

Video Relic of Saint Draws Catholics Worried About Immigration Issue

A Roman Catholic saint who is a figure of devotion for those crossing the border into the United States is attracting believers concerned about the plight of undocumented immigrants. Mike O'Sullivan reports from Los Angeles, where a relic of Saint Toribio has drawn thousands to local churches.
Video

Video US Awards Medal of Honor for Heroics in Bloodiest of Afghan Battles

U.S. combat troops are withdrawing from Afghanistan, on pace to leave the country by the end of this year. But on Monday, U.S. President Barack Obama took time to honor a soldier whose actions while under fire in Afghanistan earned him the Medal of Honor. VOA's Jeff Seldin has more from the Pentagon.
Video

Video Ukraine Rebels Surrender MH17 Black Boxes

After days of negotiations, a senior separatist leader handed over two black boxes from an airliner downed over eastern Ukraine to Malaysian experts early Tuesday. While on Monday, the U.N. Security Council unanimously demanded that armed groups controlling the crash site allow safe and unrestricted access to the wreckage.
Video

Video In Cambodia, HIV Diagnosis Brings Deadly Shame

Although HIV/AIDS is now a treatable condition, a positive diagnosis is still a life altering experience. In Cambodia, people living with HIV are often disowned by friends, family and the community. This humiliation can be unbearable. We bring you one Cambodian woman’s struggle to overcome a life tragedy and her own HIV positive diagnosis.
Video

Video Nature of Space Exploration Enters New Age

Forty-five years ago this month, the first humans walked on the moon. It was during an era of the space race between the United States and the Soviet Union. World politics have changed since then and -- as Elizabeth Lee reports -- so has the nature of space exploration.

AppleAndroid