News / Science & Technology

Scientists Develop Cancer-Killing Protein

Michael King (r) Cornell professor of biomedical engineering and the study’s senior author, works with students in lab.
Michael King (r) Cornell professor of biomedical engineering and the study’s senior author, works with students in lab.
Jessica Berman
Some 90 percent of people who die from cancer do so, say experts, because the disease has metastasized, or spread.  Researchers say they believe they can dramatically reduce the mortality rate with a protein combination that kills cancer cells on contact.  

Surgery, radiation and chemotherapy are often effective at treating people with a solid tumor, but once the cancer has spread and formed tiny tumors at distant sites, chances for a successful recovery are dismal.

Now researchers at Cornell University in New York have isolated a protein that goes by the acronym of TRAIL that causes metastasizing cancer cells to implode on contact.

The biomedical engineers led by Mike King have attached TRAIL to immune system white blood cells so it circulates throughout the body, ready to destroy.

“And so now, in the blood flow, all of your white blood cells become essentially cancer-killing machines.  And whenever they bump into a cancer cell that makes its way in the circulation, that cancer cell will go on to die within a few hours," said King.

King says TRAIL leaves healthy cells alone.

The protein complex triggers apoptosis, or cellular suicide, in cancer cells.  Apoptosis is what keeps normal cells from growing out of control.
 
In initial experiments with TRAIL, King says researchers injected the protein complex into saline but it was only 60 percent effective at killing cancer cells.  Researchers say the reason was that there were no immune cells for the suicide protein to latch on to.  

When investigators, however, injected TRAIL into the circulating blood of mice with cancer, the therapy was nearly 100 percent effective in causing the metastasized cells to kill themselves.  

“We believe the fluid forces, the pressures and forces of blood flow help give the signals to the cancer cells.  So basically the fluid flow pushes the cells together, the cancer cell and the altered white cell," said King.

Cancer also commonly spreads through the lymphatic system, which transports clear, colorless fluid containing white blood cells throughout the body.  King says bioengineers are also working on a targeted treatment to kill cancer cells that have made their way into lymphatic fluid.

An article describing an experimental treatment for cancer metastasis is published in the journal Proceedings of the National Academy of Sciences.  

You May Like

At International AIDS Conference One Goal, Many Paths

The 12,000 delegates attending 20th International AIDS Conference in Melbourne have vastly different visions about how to eradicate disease More

Disasters May Doom Malaysia’s Flag Carrier

Even before loss of two jets loaded with passengers on international flights, company had been operating in red for three years, accumulating deficit of $1.3 billion More

Afghan Presidential Vote Audit Continues Despite Glitches

Process has been marred by walkouts by representatives of two competing candidates, Abdullah Abdullah and Ashraf Ghani More

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
Nature of Space Exploration Enters New Agei
X
Elizabeth Lee
July 20, 2014 2:36 AM
Forty-five years ago this month, the first humans walked on the moon. It was during an era of the space race between the United States and the Soviet Union. World politics have changed since then and -- as Elizabeth Lee reports -- so has the nature of space exploration.
Video

Video Nature of Space Exploration Enters New Age

Forty-five years ago this month, the first humans walked on the moon. It was during an era of the space race between the United States and the Soviet Union. World politics have changed since then and -- as Elizabeth Lee reports -- so has the nature of space exploration.
Video

Video Chicago’s Argonne Lab Developing Battery of the Future

In 2012, the U.S. Department of Energy’s Office of Science awarded a $120 million grant to a new technology center focused on battery development - headquartered at Argonne National Laboratory in suburban Chicago, Illinois. As VOA’s Kane Farabaugh reports, there scientists are making the next technological breakthroughs in energy storage.
Video

Video In NW Pakistan, Army Offensive Causes Massive Number of Displaced

Pakistan’s army offensive in North Waziristan has resulted in the large-scale displacement of the local population. VOA's Ayaz Gul reports from northwest Pakistan where authorities say around 80 percent of the estimated 1 million internally displaced persons [IDPs] have settled in Bannu district, while much of the remaining 20 percent are scattered in nearby cities.
Video

Video Kurdish Peshmerga Force Secures Kirkuk, Its Oil

The Kurdistan regional government has sent its Peshmerga troops into the adjacent province of Kirkuk to drive out insurgents, and to secure the area's rich oil fields. By doing this, the regional government has added a fourth province to the three it officially controls. The oil also provides revenue that could make an independent Kurdistan economically strong. VOA’s Jeffrey Young went out with the Peshmerga and filed this report.
Video

Video Malaysia Reeling: Second Air Disaster in Four Months

Malaysia is reeling from the second air disaster in four months involving the country’s flag carrier. Flight 340 vanished in March and despite an extensive search, no debris has been found. And on Thursday, Flight 17, likely hit by a surface-to-air missile, came apart over eastern Ukraine. The two incidents together have left more than 500 people dead. VOA Correspondent Steve Herman reports from Kuala Lumpur.
Video

Video Diplomatic Crisis Grows Over MH17 Plane Crash

The Malaysia Airlines crash in eastern Ukraine is drawing reaction from leaders around the world. With suspicions growing that a surface-to-air missile shot down the aircraft, there are increasing tensions in the international community over who is to blame. Henry Ridgwell reports for VOA from London.
Video

Video Undocumented Immigrants Face Perilous Journey to US, No Guarantees

Every day, hundreds of undocumented immigrants from Central America attempt the arduous journey through Mexico and turn themselves over to U.S. border patrol -- with the hope that they will not be turned away. But the dangers they face along the way are many, and as Ramon Taylor reports from the Rio Grande Valley in Texas, their fate rests on more than just the reception they get at the US border.
Video

Video Scientists Create Blackest Material Ever

Of all the black things in the universe only the infamous "black holes" are so black that not even a tiny amount of light can bounce back. But scientists have managed to create material almost as black, and it has enormous potential use. VOA’s George Putic has more.
Video

Video Fog Collector Transforming Maasai Water Harvesting in Kenya

The Maasai people of Kenya are known for their cattle-herding, nomadic lifestyle. But it's an existence that depends on access to adequate water for their herds and flocks. Lenny Ruvaga reports for VOA, on a "fog collector."

AppleAndroid