News / Science & Technology

Scientists Develop Cancer-Killing Protein

Michael King (r) Cornell professor of biomedical engineering and the study’s senior author, works with students in lab.
Michael King (r) Cornell professor of biomedical engineering and the study’s senior author, works with students in lab.
Jessica Berman
Some 90 percent of people who die from cancer do so, say experts, because the disease has metastasized, or spread.  Researchers say they believe they can dramatically reduce the mortality rate with a protein combination that kills cancer cells on contact.  

Surgery, radiation and chemotherapy are often effective at treating people with a solid tumor, but once the cancer has spread and formed tiny tumors at distant sites, chances for a successful recovery are dismal.

Now researchers at Cornell University in New York have isolated a protein that goes by the acronym of TRAIL that causes metastasizing cancer cells to implode on contact.

The biomedical engineers led by Mike King have attached TRAIL to immune system white blood cells so it circulates throughout the body, ready to destroy.

“And so now, in the blood flow, all of your white blood cells become essentially cancer-killing machines.  And whenever they bump into a cancer cell that makes its way in the circulation, that cancer cell will go on to die within a few hours," said King.

King says TRAIL leaves healthy cells alone.

The protein complex triggers apoptosis, or cellular suicide, in cancer cells.  Apoptosis is what keeps normal cells from growing out of control.
 
In initial experiments with TRAIL, King says researchers injected the protein complex into saline but it was only 60 percent effective at killing cancer cells.  Researchers say the reason was that there were no immune cells for the suicide protein to latch on to.  

When investigators, however, injected TRAIL into the circulating blood of mice with cancer, the therapy was nearly 100 percent effective in causing the metastasized cells to kill themselves.  

“We believe the fluid forces, the pressures and forces of blood flow help give the signals to the cancer cells.  So basically the fluid flow pushes the cells together, the cancer cell and the altered white cell," said King.

Cancer also commonly spreads through the lymphatic system, which transports clear, colorless fluid containing white blood cells throughout the body.  King says bioengineers are also working on a targeted treatment to kill cancer cells that have made their way into lymphatic fluid.

An article describing an experimental treatment for cancer metastasis is published in the journal Proceedings of the National Academy of Sciences.  

You May Like

Arab League Delays Forming Joint Force

Delay grows out of one of original obstacles facing pan-Arab force, analysts say: 'They may agree on the principle, but they continue to argue about how to implement the project' More

Pakistan Demands Afghanistan Protect Its Kabul Mission, Staff

Officials in Islamabad say Afghan agents are harassing Pakistani embassy personnel, particularly those living outside of mission’s compound More

US Survey: Trump Lead Grows in Republican Presidential Contest

Quinnipiac University poll shows brash billionaire real estate mogul with 28 percent support among Republican voters More

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
Colombians Flee Venezuela as Border Crisis Escalatesi
X
August 27, 2015 2:08 AM
Hundreds of Colombians have fled Venezuela since last week, amid an escalating border crisis between the two countries. Last week, Venezuelan President Nicolas Maduro ordered the closure of a key border crossing after smugglers injured three Venezuelan soldiers and a civilian. The president also ordered the deportation of Colombians who are in Venezuela illegally. Zlatica Hoke reports.
Video

Video Colombians Flee Venezuela as Border Crisis Escalates

Hundreds of Colombians have fled Venezuela since last week, amid an escalating border crisis between the two countries. Last week, Venezuelan President Nicolas Maduro ordered the closure of a key border crossing after smugglers injured three Venezuelan soldiers and a civilian. The president also ordered the deportation of Colombians who are in Venezuela illegally. Zlatica Hoke reports.
Video

Video Is China's Economic Data Accurate?

Some investors say China's wild stock market gyrations have been made worse by worries about the reliability of that nation's economic data. And some critics say the reports can mislead investors by painting an unrealistically-strong picture of the economy. A key China scholar says Beijing is not fudging ((manipulating)) the numbers, but that the economy is evolving quickly from smoke-stack industries to services, and the ways of tracking new economic activity are falling behind the change. V
Video

Video Next to Iran, Climate at Forefront of Obama Agenda

President Barack Obama this week announced new initiatives aimed at making it easier for Americans to access renewable energy sources such as solar and wind. Obama is not slowing down when it comes to pushing through climate change measures, an issue he says is the greatest threat to the country’s national security. VOA correspondent Aru Pande has more from the White House.
Video

Video Shipping Containers Provide Experimental Housing

Housing prices around the San Francisco Bay area are out of reach for many people, so some young entrepreneurs, artists and tech industry workers are creating their own houses using converted shipping containers. But as VOA's Mike O’Sullivan reports from Oakland, the effort requires ingenuity and dealing with restrictive local laws.
Video

Video Arctic Draws International Competition for Oil

A new geopolitical “Great Game” is underway in earth’s northernmost region, the Arctic, where Russia has claimed a large area for resource development and President Barack Obama recently approved Shell Oil Company’s test-drilling project in an area under U.S. control. Greg Flakus reports.
Video

Video Philippine Maritime Police: Chinese Fishermen a Threat to Country’s Security

China and the Philippines both claim maritime rights in the South China Sea.  That includes the right to fish in those waters. Jason Strother reports on how the Philippines is catching Chinese nationals it says are illegal poachers. He has the story from Palawan province.
Video

Video Technique May Eliminate Drill-and-Fill Dental Care

Many people dread visiting dentists because they're afraid of drills. Now, however, a technology developed by a British firm promises to eliminate the need for mechanical cleaning of dental cavities by speeding a natural process of tooth repair. VOA’s George Putic reports.
Video

Video China's Spratly Island Building Said to Light Up the Night 'Like A City'

Southeast Asian countries claim China has illegally seized territory in the Spratly islands. It is especially a concern for a Philippine mayor who says Beijing is occupying parts of his municipality. Jason Strother reports from the capital of Palawan province, Puerto Princesa.
Video

Video Ages-old Ice Reveals Secrets of Climate Change

Ice caps don't just exist at the world's poles. There are also tropical ice caps, and the largest sits atop the Peruvian Andes - but it is melting, quickly, and may be gone within the next 20 years. George Putic reports scientists are now rushing to take samples to get at the valuable information about climate change locked in the ice.
Video

Video French Experiment in Integrating Roma Under Threat

Plans to destroy France’s oldest slum have sparked an outcry on the part of its Roma residents. As Lisa Bryant reports from the Paris suburb of La Courneuve, rights groups argue the community is a fledgling experiment on integrating Roma who are often outcasts in many parts of Europe.
Video

Video Kenyans Turn to Agriculture for Business

Each year Kenyan universities continue to churn out graduates for the job market despite the already existing high rate of unemployment among youth in the country. Some of these young men and women have realized that agriculture can be as rewarding as any other business or job, and they are resorting to agribusiness in large numbers as a way of tackling unemployment. Rael Ombuor reports for VOA.
Video

Video First Women Graduate Elite Army Ranger School

Two women are making history for the U.S. Army by proving they are among the toughest of the tough. VOA's Carla Babb reports from Fort Benning, Georgia as 94 men and those two women rise as graduates of the difficult Ranger school.

VOA Blogs