U.S. Health and Human Services Secretary Kathleen Sebelius is resigning after overseeing the botched rollout of President Barack Obama's signature health care law.
Kathleen Sebelius' resignation comes just a week after enrollment closed for the first year of what is commonly known as Obamacare.
The opening weeks of the enrollment period were marred by widespread website woes, limiting access for millions of people.
Republicans called for Secretary Sebelius' resignation, but Obama publicly supported her.
However, she was conspicuously absent last week when the president announced the enrollment period was ultimately successful. It surpassed the 7 million figure the Obama administration had predicted.
President Obama is expected Friday to nominate Sylvia Mathews Burwell, the director of the Office of Management and Budget, to replace Sebelius.
Sebelius, who is 65, is a former governor of Kansas. She has served as head of Health and Human Services for five years.