News / Health

Scientists Explore Stem Cells to Treat Diabetic Blindness

TEXT SIZE - +
Jessica Berman
Millions of diabetics around the world are threatened with vision loss, a secondary effect of their disease, but researchers are exploring whether stem cells can be used to treat or prevent this diabetic complication. 

Juvenile and adult-onset diabetes result when the body's ability to regulate blood sugar levels goes awry. When the condition becomes chronic, it can lead to cardiovascular disease, damage the kidneys and affect blood flow to the limbs, sometimes requiring amputations.

The disease also affects the eyes, according to Alan Stitt of Queen’s University in Belfast, Ireland. Chronically high blood sugar levels can cause a condition called diabetic retinopathy, in which the tiny blood vessels that nourish the retina, the light sensitive tissue at the back of the eye, become blocked or leak.

“They then can actually no longer carry the oxygen and the nutrients that the retina requires," Stitt says. "And the retina becomes increasingly dysfunctional as a result of these blood vessels not functioning properly.”

If left untreated, diabetic retinopathy can lead to partial or total blindness.

Stitt, who directs the Queen's University Center for Vision and Vascular Science, is participating in a European-led study called Repair of Diabetic Damage by Stromal Cell Administration (REDDSTAR). 

Researchers from the U.S., Northern Ireland, Germany, the Netherlands, Denmark and Portugal are also taking part. Each team is trying to prevent and minimize damage to a particular organ as a result of diabetes.

The scientists are using adult stem cells isolated from bone marrow, the spongy tissue inside bones. Stem cells are master cells that can be coaxed to morph into any type of tissue cell in the body.

In Stitt’s laboratory, the stem cells are being injected directly into the eyes of mice bred to have diabetic retinopathy. So far, he says, the results are encouraging, showing signs that the progression toward blindness can be halted as the tiny retinal blood vessels are repaired and regenerated by the stem cells:

“They are very clever cells, because what we know from the evidence we’ve got is that they seem to have this ability to go to where the tissue needs them to go," Stitt says. "So they recognize where there’s not enough blood vessels and they can actually then participate in the blood vessel regrowth.”

Current treatments for diabetic retinopathy, including laser surgery to stop retinal leakage, are directed toward patients with advanced disease. Such medical interventions are painful, costly and frequently unsuccessful.

Stitt expects to begin human trials with the potentially eyesight-saving stem cell therapy in about two years.

You May Like

Multimedia Anti-Keystone XL Protests Continue

Demonstrators are worried about pipeline's effect on climate change, their traditional way of life, health and safety More

Thailand's Political Power Struggle Continues

Court gave Prime Minister Yingluck Shinawatra until May 2 to prepare her defense over abuse of power charges but uncertainty remains over election timing More

Malaysia Plane Search Tests Limits of Ocean Mapping Technology

Expert tells VOA existing equipment’s maximum operating depth is around 6 kilometers as operation continues on ocean bed for any trace of MH370 More

This forum has been closed.
Comments
     
There are no comments in this forum. Be first and add one

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
Pet Kangaroo Helps Spread Environmental Messagei
X
Penelope Poulou
April 22, 2014 5:53 PM
Children’s author Julia Heckathorn travels the world to learn about different ecosystems and endangered animals. She pours her knowledge into children’s books, hoping the next generation will right the environmental wrongs of our times. As in many children's books, the main character in Heckathorn's stories is an animal. Unlike those other characters, though, this one is real - a kangaroo, that lives in the author’s backyard. VOA’s Penelope Poulou has more.
Video

Video Pet Kangaroo Helps Spread Environmental Message

Children’s author Julia Heckathorn travels the world to learn about different ecosystems and endangered animals. She pours her knowledge into children’s books, hoping the next generation will right the environmental wrongs of our times. As in many children's books, the main character in Heckathorn's stories is an animal. Unlike those other characters, though, this one is real - a kangaroo, that lives in the author’s backyard. VOA’s Penelope Poulou has more.
Video

Video Pro-Russian Separatists Plan 'Federalization Referendum' in Eastern Ukraine

Pro-Russian separatists in eastern Ukraine say they plan to move forward next month with a referendum vote for greater autonomy, despite the Geneva agreement reached with Russia, the U.S. and Ukraine to end the political conflict. VOA's Brian Padden reports from the city of Donetsk in Eastern Ukraine.
Video

Video Pope Francis Hopes Dual Canonizations Will Reconcile Church

On April 27, two popes - John the XXIII and John Paul II - will be made saints in a ceremony at St. Peter’s Square. VOA religion correspondent Jerome Socolovsky says the dual canonization is part of the current pope’s program to reconcile liberals and conservatives in the Roman Catholic Church.
Video

Video In Capturing Nature's Majesty, Film Makes Case for Its Survival

French filmmaker Luc Jacquet won worldwide acclaim for his 2005 Academy Award-winning documentary "March of the Penguins". Now Jacquet is back with a new film that takes movie-goers deep into the heart of a tropical rainforest - not only to celebrate its grandeur, but to make the case for its survival. VOA's Rosanne Skirble reports.
Video

Video Boston Marathon Bittersweet for Many Runners

Monday's running of the Boston Marathon was bittersweet for many of the 36,000 participants as they finished the run that was interrupted by a double bombing last year. Many gathered along the route paid respect to the four people killed as a result of two bombings near the finish line. VOA's Carolyn Presutti returned to Boston this year to follow two runners, forever changed because of the crimes.
Video

Video International Students Learn Film Production in World's Movie Capital

Hollywood - which is part of Los Angeles - is the movie capital of the world, and many aspiring filmmakers go there in hopes of breaking into the movie business. Mike O'Sullivan reports that regional universities are also a magnet for students who hope to become producers or directors.
Video

Video Pacific Rim Trade Deal Proves Elusive

With the U.S.-led war in Iraq ended and American military involvement in Afghanistan winding down, President Barack Obama has sought to pivot the country's foreign policy focus towards Asia. One aspect of that pivot is the negotiation of a free-trade agreement among 12 Pacific Rim nations. But as Obama leaves this week on a trip to four Asian countries he has found it very difficult to complete the trade pact. VOA's Ken Bredemeier has more from Washington.
Video

Video Autistic Adults Face Housing, Job Challenges

Many parents of children with disabilities fear for the future of their adult child. It can be difficult to find services to help adults with disabilities - physical, mental or emotional - find work or live on their own. The mother of an autistic boy set up a foundation to advocate for the estimated 1.2 million American adults with autism, a developmental disorder that causes communication difficulties and often social difficulties. VOA's Faiza Elmasry reports.
AppleAndroid