News / Health

Topical Medication Might Provide Protection Against HIV

Microbiocide would kill virus where it enters the body

Boston researchers have developed a topical agent that might block the HIV virus from infecting healthy cells when it enters the body.
Boston researchers have developed a topical agent that might block the HIV virus from infecting healthy cells when it enters the body.

Multimedia

Audio
Art Chimes

Researchers have developed a topically-applied molecular microbicide capable of preventing HIV transmission. The medication works by silencing the genes that promote infection.

The microbicide is predicted to have long-lasting effects in mice and could lead to the development of an intravaginal microbicide to protect women against HIV infection, possibly for weeks at a time.

For years, scientists have tried to develop a topical microbicide to stop HIV transmission. It might be a gel or cream, used vaginally, that would act against the AIDS virus.

A variety of approaches have been tried. In newly published research, scientists at Harvard Medical School and other institutions show that RNA interference can block the virus from infecting healthy cells.

RNA interference is used by primitive organisms in place of the kind of immune system that we have. It's only been a decade or so that scientists have been trying to harness it to control human disease.

Lead researcher Judy Lieberman explains that RNA interference is a mechanism that can silence, or "knock down" the action  of one gene at a time.

"And so we were able to knock down either viral genes or the host receptor for HIV, which is called CD4, and show that we could prevent the spread of HIV infection in culture."

Doing that in culture, in the lab, is one thing. It turns out that getting RNA interference to work in the immune cells targeted by HIV is not easy.

But in a new publication, Lieberman and her colleagues describe how they did it, using mice that were genetically modified to give them a more human-like immune system. "And what this paper shows is a new way to induce gene silencing in immune cells that actually works in vivo," she says.

This is not the first topical microbicide developed to stop HIV transmission, but Lieberman says the others typically require that a woman use the product just before having sex.

"And that's a huge impediment. So what's attractive about what we've developed is that the effect appears to be quite durable, and it might be possible to treat yourself and have the protection last for a week or so."

RNA-interference is not specific to HIV/AIDS. Lieberman says previous research show that RNA can be effective in controlling some cancers and a virus that causes breathing problems in newborn babies.

But there are still challenges. "The big obstacle has been," Lieberman says, "how do you get these drugs into cells? And what we're excited about is that we now have a way, not only of introducing RNA into cells, but of also targeting them into specific cell types."

Lieberman says one advantage to RNA-based medicine is that because it is so targeted against specific genes, safety and side effects are less of an issue.

You May Like

Photogallery Americans Celebrate Thanksgiving With Feasts, Festivities

Holiday traditions include turkey dinners, 'turkey trots,' American-style football and New York parade with giant balloons More

Video For Obama, Ferguson Violence is a Personal Issue

With two years left in term, analysts say, president has less to lose by taking conversation on race further More

Video Italian Espresso Expands Into Space

When Italian astronaut Samantha Cristoforetti headed for the ISS, her countrymen worried how she would survive six months drinking only instant coffee More

This forum has been closed.
Comments
     
There are no comments in this forum. Be first and add one

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
South Africa Sees Male Circumcision as Way to Reduce HIV Infectionsi
X
November 28, 2014 3:31 PM
South Africa remains plagued by AIDS despite massive government and NGO efforts on prevention and life-sustaining Anti-Retro-Viral programs. But the country has opened up another front to reduce new HIV infections: promoting circumcision. Emilie Iob reports for VOA News from a pioneering circumcision center in Orange Farm, Johannesburg.
Video

Video South Africa Sees Male Circumcision as Way to Reduce HIV Infections

South Africa remains plagued by AIDS despite massive government and NGO efforts on prevention and life-sustaining Anti-Retro-Viral programs. But the country has opened up another front to reduce new HIV infections: promoting circumcision. Emilie Iob reports for VOA News from a pioneering circumcision center in Orange Farm, Johannesburg.
Video

Video To Make A Living, Nairobi Street Vendors Face Legal Hurdles, Physical Violence

The Nairobi City Council has been accused of brutality in dealing with hawkers in the Central Business District - in order to stop them from illegally selling their wares on the streets. Lenny Ruvaga has more for VOA News from the Kenyan capital.
Video

Video For Obama, Ferguson Violence is a Personal Issue

Throughout the crisis in Ferguson, Missouri, President Barack Obama has urged calm, restraint and respect for the rule of law. But the events in Ferguson have prompted him to call — more openly than he has before — for profound changes to end the racism and distrust that he believes still exists between whites and blacks in the United States. VOA White House correspondent Luis Ramirez reports.
Video

Video Online Magazine Gets Kids Discussing Big Questions

Teen culture in America is often criticized for being superficial. But an online magazine has been encouraging some teenagers to explore deeper issues, and rewarding their efforts. VOA religion reporter Jerome Socolovsky went to this year’s Kidspirit awards ceremony in New York.
Video

Video US Community Kicks Off Thanksgiving With Parade

Thursday is Thanksgiving in the United States, a holiday whose roots go back to the country's earliest days as a British colony. One way Americans celebrate the occasion is with parades. Anush Avetisyan takes us to one such event on the day before Thanksgiving near Washington, where a community's diversity is on display. Joy Wagner narrates
Video

Video Aung San Suu Kyi: Myanmar Opposition to Keep Pushing for Constitutional Change

Myanmar opposition leader Aung San Suu Kyi says she and her supporters will continue pushing to amend a constitutional clause that bars her from running for president next year. VOA's Than Lwin Htun reports from the capital Naypyitaw in this report narrated by Colin Lovett.
Video

Video Mali Attempts to Shut Down Ebola Transmission Chain

Senegal and Nigeria were able to stop small Ebola outbreaks by closely monitoring those who had contact with the sick person and quickly isolating anyone with symptoms. Mali is now scrambling to do the same. VOA’s Anne Look reports from Mali on what the country is doing to shut down the chain of transmission.
Video

Video Ukraine Marks Anniversary of Deadly 1930s Famine

During a commemoration for millions who died of starvation in Ukraine in the early 1930s, President Petro Poroshenko lashed out at Soviet-era totalitarianism for causing the deaths and accused today’s Russian-backed rebels in the east of using similar tactics. VOA’s Daniel Shearf reports from Kyiv.
Video

Video Hong Kong Protests at a Crossroads

New public opinion polls in Hong Kong indicate declining support for pro-democracy demonstrations after weeks of street protests. VOA’s Bill Ide in Guangzhou and Pros Laput in Hong Kong spoke with protesters and observers about whether demonstrators have been too aggressive in pushing for change.
Video

Video US Immigration Relief Imminent for Mixed-Status Families

Tens of thousands of undocumented immigrants in the Washington, D.C., area may benefit from a controversial presidential order announced this week. It's not a path to citizenship, as some activists hoped. But it will allow more immigrants who arrived as children or who have citizen children, to avoid deportation and work legally. VOA's Victoria Macchi talks with one young man who benefited from an earlier presidential order, and whose parents may now benefit after years of living in fear.
Video

Video New Skateboard Defies Gravity

A futuristic dream only a couple of decades ago, the hoverboard – a skateboard that floats above the ground - has finally been made possible. While still not ready for mass production, it promises to become a cool mode of transport... at least over some surfaces. VOA’s George Putic reports.
Video

Video Falling Gas Prices Impact US Oil Extraction

With the price of oil now less than $80 a barrel, motorists throughout the United States are benefiting from gas prices below $3 a gallon. But as VOA’s Kane Farabaugh reports, the decreasing price of petroleum has a downside for the hydraulic fracturing industry in the United States.

All About America

AppleAndroid