Egypt says it has ordered the Turkish ambassador to be expelled, following comments by Turkey's prime minister.
Saturday's decision comes after Turkish Prime Minister Recep Tayyip Erdogan renewed his criticism of Egypt's new leaders earlier in the week.
Ties between the two countries have been strained since Egypt ousted its Islamist president, Mohamed Morsi, from office several months ago.
Turkey and Egypt recalled their ambassadors in August following Turkey's sharp criticism of Egypt's leaders and Morsi's ouster.
Turkey's ambassador returned to Egypt a few weeks later, but Egypt has declined to return its ambassador to Turkey.
Turkey's government had forged a close alliance with Morsi since he won Egypt's first free presidential election in June of 2012.
Morsi was ousted by the army in July following days of mass protests by millions against his turbulent year-long rule.
Security forces have killed hundreds of anti-government protester since Morsi was toppled, drawing condemnation from human rights groups. Thousands have been arrested, including top leaders of the Muslim Brotherhood. The group has been outlawed.