"Our World" theme
week on "Our World" ... New findings from the Phoenix Mars lander ...
coordinating the response to AIDS and tuberculosis ... and the challenge of
reaching one group of people with AIDS.
FROST: "Currently today, 86 countries
criminalize sex between men. ... So you can see that kind of institutionalized
homophobia makes it very difficult to address the AIDS epidemic in those
week's International AIDS Conference, a new kind of microscope, and more. I'm
Art Chimes. Welcome to VOA's science and technology magazine, "Our
International AIDS conference ends in Mexico City
17th International AIDS Conference has just wrapped up in Mexico City.
sprawling, six-day conference brought together about 25,000 people, including
researchers, activists, political leaders and journalists from around the
1985, these gatherings have provided a place for researchers to share their
latest findings on HIV, the virus that causes the immune system disorder known
as AIDS. The conferences have also been a forum for politicians to show their
commitment to the cause, and for AIDS activists to promote more research, more
programs for prevention and treatment of HIV, and more AIDS-friendly government
correspondent Greg Flakus covered the conference, and I reached him in Mexico
City just before the event ended. I asked him first if he'd seen any progress
at the conference in the search for a cure for AIDS.
FLAKUS: Well, Art, every year the researchers and
scientists who come here present their papers on encouraging or promising lines
of research, and they caution now that
this is an incremental thing, that nobody should be expecting the announcement
of a cure.
was a presentation from the University of Texas medical school in Houston on an
announcement that came just on the eve of this conference. They made the
announcement that they'd found a protein on the HIV virus that remains
constant. One of the problems with the virus is that it keeps mutating, and
it's been very difficult for researchers to attack it because of that. But in
order to infest itself into the host it has to have one part that's constant,
and this is what Dr. Sudhir Paul and his colleague, Dr. Miguel Escobar have
found by studying the virus there in Houston. They think that by using what
they call abzymes to attack this, that they could destroy the virus. However it
will take at least five years for them just to do the testing on this. So
that's the problem with AIDS research. As the researchers say, this is
something that's going to be incremental. It's going to take a lot of time and
a lot of collaboration from people all around the world.
Q: Well, in the meantime we've got prevention.
And I know from the AIDS conferences that I went to in the 1980s and '90s,
prevention's always been an important part, not only of the fight against
HIV/AIDS but also of these conferences. What is the latest word on prevention
there in Mexico City?
FLAKUS: Well, prevention is probably the big topic
here. You'll see condoms at every corner here, literally. Everywhere you go,
different booths, different organizations are handing out condoms. And that's
one of the big messages here, that education and the use of condoms and things
that they know work from long experience now around the world, that this could
drastically reduce the instance of AIDS.
Q: The United States in recent years has been a
big AIDS donor with the PEPFAR program, the President's Emergency Plan for AIDS
Relief. But PEPFAR has been pretty controversial because of its strong emphasis
on abstinence as a prevention strategy. Did any of that controversy play out in
FLAKUS: Well not so much this year. In past years
it's been controversial, and this year it's been low-key, the approach to that.
And if anything, President Bush and the United States got some praise here from
the Secretary General of the United Nations and various officials with this
conference because of the increase in the amount of money that's given to HIV
and AIDS research and treatment and so forth.
the other hand, as I say, abstinence is not talked about much here. You do hear
some people say that it's something that can be encouraged as part of an
overall solution. But when you look at places where it's been tried, according
to the people I've talked to, it has a 76 percent failure rate. So they say
it's better to face the reality that people are going to have sex, people are
going to use drugs intravenously, and so forth. And so it's better to
concentrate on treatments that we know will work or the preventive we know
Q: Well, finally, Greg, can you give us a sense
of what the atmosphere has been like? There are, what?, 25,000 or so people
FLAKUS: Yes, it's one of the biggest they've had.
It's the first one in Latin America. I should mention that the main conference
is taking place in this huge convention center here in Mexico City, the Centro
Banamex. But outside they set up these two gigantic tents, and in there you
have all the various representatives — the NGOs, various national AIDS
foundations, you have different groups representing, for example, women, sex
workers, you have several gay organizations represented there. All of these
people are talking about prevention. They're talking about helping, for
example, orphans. I talked to a group from Taiwan that has set up various
shelters for people, not only in Taiwan but in mainland China. So there are a
lot of things like that, where people come together and they share ideas. And
so you learn from that.
guess that's why they call it the International AIDS Conference. VOA
correspondent Greg Flakus was our man at the 17th International AIDS
Conference. It just ended in Mexico City. Thanks a lot, Greg.
FLAKUS: Thank you, Art.
Men who have sex with men have greater risk of HIV infection
at the Mexico City AIDS conference, a new report released there by the American
Foundation for AIDS Research, or amfAR, says the rate of HIV infections among
men who have sex with men is many times greater than HIV infections in the
general population. As VOA's Rosanne Skirble reports, activists are calling for
targeted prevention programs and resources, especially in low- and
middle-income countries, where the problem is most acute.
SKIRBLE: The amfAR report looks at the response of
128 countries to a 2006 United Nations initiative promoting universal access to
HIV prevention, treatment and care. But the amfAR report focuses on one
HIV-infected population group: men who have sex with men, better known by the
acronym "MSM". The term describes this group's sexual behavior, and
does not imply a homosexual lifestyle. Report co-author and Johns Hopkins
University epidemiologist Chris Beyrer says a review of all published HIV data
shows that MSM makes up a large and growing portion of the AIDS epidemic in
every region of the world.
BEYRER: "In Latin America, these men were 33
times as likely as in the general population. And that was the most extreme
that we saw. For Asia, men who have sex with men, were 18 times more likely to
have HIV infection, and in Sub-Saharan Africa, which of course has been the
area where the general population rates [of HIV infection] are the highest, men
who have sex with men were still more than three times more likely to have HIV
than adults in the reproductive age population."
SKIRBLE: amfAR CEO Kevin Frost says criminalization
of male-with-male sexual activities is driving the MSM epidemic in many
FROST: "Currently today, 86 countries
criminalize sex between men. That makes it enormously difficult to reach this
population. More than ten of those countries have laws that punish sex between
men with more than ten years in prison, and seven make it punishable by death.
So you can see that kind of institutionalized homophobia makes it very
difficult to address the AIDS epidemic
in those men."
SKIRBLE: The amfAR report links MSM prevalence to the
failure of many countries to launch any kind of MSM-targeted response, as
described in the U.N.'s 2006 call-to-action on HIV/AIDS programs. The report
found that nearly half of all countries did not provide any data on MSM in
response to the U.N. initiative. Among those nations that did, 71 percent have
not launched any MSM-specific programs. amfAR's Kevin Frost says that must
FROST: "And, history, if it has taught us
anything about this epidemic, it has taught us that if we are going to be
effective in our response, our response has to be comprehensive, meaning it has
to address all of the populations at risk, whether that is men who have sex
with men or drug users or sex workers."
SKIRBLE: The report concludes that despite the upward
trend in MSM-related HIV infections, resources to deal with them are scarce. In
Latin America, for example, where the AIDS conference is being held, MSM
represents 25 percent of the people living with HIV. But MSM programs get less
than one percent of total spending on HIV/AIDS prevention. Co-author Chris
Beyrer says it's essential that funding priorities be adjusted to address this
BEYRER: "What we're trying to do, of course, is
to use that data to advocate for resources. When you find this kind of a
problem and you have the evidence, you want evidence-based approaches to
prevention for these men, increased surveillance, health care access,
antiretroviral therapy, condoms, lubricants. And that has to be paid for."
SKIRBLE: Chris Beyrer says failure to provide health
care, prevention and treatment for the MSM population amounts to nothing less
than a denial of basic human rights to health care and, ultimately to life
itself. Rosanne Skirble, VOA News, Mexico City.
tuned. We'll have one more AIDS report later on in the show. But first ...
Mars spacecraft finds unexpected material in red planet's soil
scientists this week said the Phoenix Mars Lander has detected the presence of
a chemically-reactive salt called perchlorate in the Martian soil.
is a mineral that also occurs naturally in soil here on Earth, in places like
the Atacama Desert in Chile, where the soil has been described as
Mars-like. It's a toxic material that
is used in pyrotechnic devices like fireworks and automobile air bags.
investigator Peter Smith of the University of Arizona says studies on Earth
indicate that finding perchlorates in Martian soil doesn't rule out the
possibility of life on Mars.
SMITH: "These compounds are quite stable in
soil and water and do not destroy organic materials under normal circumstances.
In fact, there are species of perchlorate-reducing microbes that live on the
energy provided by this oxidant. In itself, it is neither good nor bad for
added that the Phoenix scientists didn't expect to find perchlorate on Mars.
announcement in a hastily-called telephone news conference came after several
days of Internet rumors about some big discovery possibly relating to life on
Mars, so big that even the White House had been given a special briefing, the
NASA spokesman Dwayne Brown said the rumors of a White House briefing were just
that — rumors.
Phoenix scientists are continuing their remote-control analysis of the Martian
soil and promise to let us know just as soon as they have anything new to
Website of the Week features free, full-length documentary films
again for our Website of the Week, when we showcase interesting and innovative
hit movies from Hollywood, Bollywood and every place in between tend to crowd
out smaller films and, especially, documentaries from your local cinema.
now there's a new website that wants to help build an audience for
documentaries via the Internet.
ALLEN: "We are in the business of providing
award-winning documentary films free to audiences worldwide, via the web."
Allen is the CEO of SnagFilms.com, a brand new site where you can watch
full-length documentaries online.
features a range of high quality films, not only from top producers like
National Geographic and the major American public broadcasting network, PBS,
but also from smaller, independent filmmakers.
ALLEN: "Some of them known well to indy film
fans and documentarians, and they've made one or more films that are often
issues-based, and so deeply of personal importance to them, and therefore we
think lending themselves well to the viral distribution that Snagfilms
you're a filmmaker, you can submit your festival-quality documentary to
SnagFilms. For now, most of the films on the site are from the U.S., but Rick
Allen says he hopes to expand with more international offerings.
thing that sets SnagFilms apart is that viewers are encouraged to share the
movies by posting them on their own website.
ALLEN: "Snag has the ability to take our films
and open up your own virtual movie theater on any webpage, on your social
network page — Facebook, MySpace — on your blog, so that your visitors, your
friends can share the films that are important to you in the environment
they're already congregating in."
don't need to be a computer programmer to do this. It's as easy as
copy-and-paste, or for many popular sites just a mouse-click or two.
documentary film festival on your computer at SnagFilms.com, or get the link to
this and more than 200 other Websites of the Week from our site,
MUSIC: W. Bennett — "Pride in Our
listening to VOA's science and technology magazine, Our World. I'm Art Chimes
Tiny new microscope updates standard lab bench model
Internet is a great new tool. Sometimes, though, what you need is a new version
of an old tool. Reporter Eric Libby has a story about a 21st century update to
a laboratory standby that's been around for more than 400 years.
LIBBY: The word "microscope" brings to
mind a big, clunky, fragile piece of equipment. But Changhuei Yang from the
California Institute of Technology and his colleagues invented a smaller, more
portable version. Their optofluidic microscope is about a square centimeter in
size, magnifies images by 10–20 times, and costs about $10 to make. The
inspiration for the design came from floaters — the small specks of dust and
debris that land on our eyeballs.
YANG: "And sometimes they get very close to
the retina, and when that happens you can see them very clearly with very sharp
resolution. They're actually very tiny, on the order of millimeters, but when
you see them you can get a pretty big image of them. So this actually inspired
us to think about whether we can actually a use similar principle to develop a
microscope that doesn't actually use any lenses or any other complicated
LIBBY: Based on this idea, Yang took a
light-sensing chip from a digital camera and coated it with metal.
YANG: "And then what we do is we punch a line
of very small holes on this layer of metal. So when we shine light down on this
chip, the light can only pass through to the sensor underneath through the
LIBBY: A sample from blood or saliva or water is
placed on the chip. As it floats over the holes, objects and microorganisms in
the fluid block light from reaching the sensor. These shadows can be converted
into a two-dimensional image — just like in a camera — and downloaded to a
computer. Yang says the device is not just simple and small.
YANG: "It's very rugged because there is no
lens to break. We can make an iPod-sized [wallet-sized] device that can fit
easily into a clinician's back pocket. It actually can use sunlight as its
LIBBY: Yang sees this device becoming a common tool
for doctors and aid workers. It can scan water sources for dangerous bacteria
and parasites. Doctors can use it to diagnose diseases in patients living in
remote areas. Yang says it may even help detect diseases before any obvious
physical symptoms appear.
YANG: "Because it's small enough, we can
start to think about creating [an] analysis device that's implantable into the
human body. And this would be useful for tracking things that are floating in
LIBBY: Patients could then be monitored more
effectively and treated earlier. But Yang says this will not happen just yet.
He is working to extend the lifespan of his microscope, which currently only
lasts a few weeks. Nevertheless, Yang says the micro-microscopes should be
available to clinicians within a couple of years. This is Eric Libby in
Experts urge coordinated response to AIDS and tuberculosis
is one of the leading causes of death in people infected with HIV, accounting
for about 13 percent of AIDS deaths worldwide.
As Véronique LaCapra reports, doctors working with the World Health
Organization stress the need to coordinate the response to these two
catastrophic epidemics, and integrate TB screening and treatment into HIV care
LaCAPRA: More than two billion people — one third of
the world's population — are infected with tuberculosis bacilli, the bacteria
that cause TB. The disease disproportionately affects the world's poor; the
vast majority of TB deaths are in developing countries.
the general population, one in ten people who are infected with TB will develop
the disease in their lifetime. But for people who are HIV-positive, TB presents
a much greater risk.
HAVLIR: "In patients who have HIV disease, TB
is the major complication, or opportunistic infection, and also the leading
cause of death."
LaCAPRA: Dr. Diane Havlir is the Chief of the
HIV/AIDS Division at San Francisco General Hospital in California.
HAVLIR: "It's estimated that just over a third
of all the people living with HIV, which means over 10 million people, are
infected with tuberculosis."
LaCAPRA: Countries suffering the highest incidence of
HIV and AIDS bear much of burden. According to the WHO, 85 percent of
HIV-positive TB cases are in Africa.
can be difficult to diagnose, says Havlir, particularly in developing
countries, which often have limited diagnostic tools.
HAVLIR: "In most places of the world what's
still used to diagnose tuberculosis is microscopic examination of sputum, which
was developed over 100 years ago."
LaCAPRA: But using a microscope to look for TB
bacteria in the thick mucus people cough up from their lungs often doesn't work
HAVLIR: "Only about 50 percent of patients who
have tuberculosis and HIV will actually have the tuberculosis bacilli visible
on the smear under the microscope. So people have tuberculosis in their body,
but there's not enough in their sputum that we can actually see it, so that
really makes the diagnosis challenging."
LaCAPRA: It's also challenging to recognize the
symptoms of TB in someone with HIV. An otherwise healthy person who gets sick
from TB usually develops pneumonia-like symptoms — coughing, fever, chest
pains, and sweats.
in people with weak immune systems, like AIDS patients, TB can spread
throughout the body.
HAVLIR: "They can get tuberculosis in their
lymph nodes, and get huge swollen glands. The glands can be in their belly and
provide very severe abdominal pain. The tuberculosis can spread to their brain
and they can have seizures and headaches. So once patients get AIDS and
tuberculosis, the symptoms are really much, much more diverse."
TEXT: Havlir proposes that to effectively fight
the spread of tuberculosis, HIV programs must make TB control a priority. She
says the first step is to increase routine testing for TB in HIV clinics.
HAVLIR: "TB is a transmissible disease, and the
sooner that we find [infected] people, the sooner we can treat people, and the
less period of time that they are able to transmit tuberculosis to
LaCAPRA: Since TB is highly contagious — spreading
through the air when someone with TB coughs, sneezes, or even talks — early
diagnosis is critical to preventing an infected person from spreading the
disease to others. Family members are especially at risk, as are other patients
in a health care facility. Havlir says that just having TB patients wear a
simple paper mask over their mouths can help prevent transmission.
for TB can also provide direct benefits to the person getting tested, even if the
results are negative. For an
HIV-positive person who does not have TB, says Havlir, taking a single
antibiotic called isoniazid may reduce their risk of getting TB in future by up
to 60 percent.
HAVLIR: "Another tool that we have in order to
prevent the risk of tuberculosis in our HIV-infected patients is HIV therapy
itself. Because one of the reasons that our patients with HIV are so
susceptible to tuberculosis is because their immune system is impaired. When we
treat them for HIV their immune system improves, and they become less
susceptible to tuberculosis."
LaCAPRA: Havlir discusses these and other strategies
to coordinate TB and HIV control in the July 23 issue of the Journal of the
American Medical Association. For Our World, I'm Véronique LaCapra.
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