A security official in Pakistan says a suspected U.S. drone fired missiles at a building used by Taliban militants in Pakistan's Kurram tribal region, near the Afghan border.
Witnesses say at least 12 people were killed in the missile attack. The security official did not immediately confirm the witnesses' claims.
If verified, this would be the first suspected drone attack in Kurram.
The strike comes just days after the new U.S. envoy to the region, Richard Holbrooke, visited Pakistan to talk to senior officials about security in the border region.
There have been more than 30 similar missile strikes on Pakistani territory since the middle of last year, despite the public objections of the Pakistani government. The strikes have generally targeted al-Qaida and Taliban militants.
Some information for this report was provided by AFP, AP and Reuters.