Losing European Champions League finalists Valencia of Spain will find the going a little different after failing to qualify for the tournament this year. Instead, the Spanish football club is in the UEFA Cup and Friday's draw has Valencia going to Russia for the first round to face newcomer Chernomorets Novorossyisk.
Valencia officials were quick to admit they had no idea what to expect when they travel to play against the Black Sea club.
Some of Europe's other big clubs will also be traveling east in the 96-team draw. Italy's AC Milan must overcome Bate Borisov of Belarus, while city rivals Inter Milan face the Romanian club Brasov and Fiorentina is pitted against Ukrainians Dnepr Dnepropetrovsk.
Meanwhile, Italian Series-A side Parma, which failed to reach the Champions League group stage, are drawn against Finland's HJK Helsinki. Last season's Champions League semi-finalists Leeds United must face the Portuguese hope Maritimo, while fellow English Premier League side Chelsea have a stern test against Levski Sofia.
Among some of the other matchups in the UEFA Cup's first round, which begins September 13:
Ipswich Town vs. Torpedo Moscow
Aston Villa vs.Croatia's Varteks
Scotland's Rangers vs. Makhachkala Russia
Hibernian (Scotland) vs. AEK Athens
Hertha Berlin vs. Westerlo (Belgium)
Freiburg vs. SKM Pucho (Slovakia)
Union Berlin vs. Haka (Finland)
Real Zaragoza vs. Silkeborg (Denmark)
Celta Vigo vs. Sigma Olomouc (Czech)
Paris Saint-Germain vs. Rapid Bucharest
Ajax Amsterdam vs. Apollon Limassol (Cyprus)
Sporting Lisbon vs. Midtjyllan (Denmark)