A car bomb exploded in a heavily policed area of Syria's capital, causing several injuries as well as damage to government buildings, according to Syria's state media.
The explosion took place Monday in the Kafr Sousa neighborhood of Damascus, which houses many security installations.
The British-based Syrian Observatory for Human Rights, which monitors the violence in Syria, said the blast was near an Iranian school and caused causalities, but did not give further details.
Car bombings in the central part of Damascus are relatively rare.
In another development Monday, the Syrian Observatory for Human Rights said government helicopter gunships dropped barrel bombs on residential neighborhoods in Aleppo, killing at least 12 people.
Also Monday, the Israeli military said it struck a target in Syria in response to mortar fire that hit the Israeli-occupied Golan Heights. Syria's military said the Israeli missiles caused only material damage.
In Washington, Defense Secretary Ash Carter said any military cooperation between the Untied States and Russia to strike targets in Syria would be transactional and not based on trust. At a news conference at the Pentagon, Carter and chairman of the Joint Chiefs of Staff Gen. Joseph Dunford said any cooperation with Russia would include measures to ensure U.S. operation security.
U.S. Secretary of State John Kerry has proposed trying to establish closer military cooperation and intelligence-sharing with Russia to fight extremist groups in Syria.
Following a meeting with the Association of Southeast Asian Nations, Kerry responded to comments made by Carter and Dunford by saying that he still has some concerns about whether Russia is really prepared to step up and work with U.S. forces in Syria. That's why, Kerry said, he didn't publicly announce any kind of cooperation with Russia.
“Because we’ve been disappointed in the past,” he said.
Kerry said "a lot of homework" still needs to be completed before either Russia or the U.S. makes any public announcements, but discussions will continue to be held "quietly." He said he hopes to make a public announcement about a plan by the first week in August.