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Egyptian authorities say at least five people are dead in the city of Suez in clashes between police and protestors, the first reported fatalities in a day of nationwide protests marking the second anniversary of the uprising against former president Hosni Mubarak.
It was not immediately clear whether the fatalities were police or civilians.
Reports quote the government health ministry saying more than 250 people were injured in protests in key cities, including Cairo, Alexandria, Port Said and Suez.
Egyptian news outlets late Friday also reported government buildings were set on fire in Suez.
The secular-leaning political opposition called Friday's protests against current President Mohamed Morsi and his Islamist Muslim Brotherhood allies. Opposition leader Mohamed ElBaradei sent a message on Twitter calling on protesters to "finally achieve the objectives of the revolution."
Earlier, in Cairo, television footage showed thousands of protesters marching toward Tahrir Square, where police fired tear gas at stone-throwing demonstrators attempting to breach barriers that security forces had erected to protect government buildings.
On Thursday, President Morsi urged people to stay calm and mark the anniversary peacefully. The Muslim Brotherhood has announced it will not take part in celebrations or protests, but will instead launch a charity drive.