Global stocks tumbled Friday and oil fell below $80 a barrel after news of a possibly vaccine-resistant coronavirus variant sent investors scurrying to the safety of bonds, the yen and the Swiss franc.
Little is known of the variant, detected in South Africa, Botswana and Hong Kong, but scientists say it has an unusual combination of mutations, may be able to evade immune responses and could be more transmissible.
British authorities think it is the most significant variant to date and have hurried to impose travel restrictions on southern Africa, as did Japan, the Czech Republic and Italy on Friday.
The European Union also said it aimed to halt air travel from the region.
The World Health Organization is convening an experts' meeting later Friday to evaluate whether the new variant is a "variant of concern."
Global shares fell 0.8% and were on course for their worst week since early October.
U.S. stock indexes opened sharply lower Friday, with travel, bank and commodity-linked stocks bearing the brunt of a selloff triggered by the discovery of a new and possibly vaccine-resistant coronavirus variant.
The Dow Jones Industrial Average fell 437.69 points, or 1.22%, at the open to 35,366.69.
The S&P 500 opened lower by 36.83 points, or 0.78%, at 4,664.63, while the Nasdaq Composite dropped 180.85 points, or 1.14%, to 15,664.38 at the opening bell.
"Markets have been quite complacent about the pandemic for a while, partly because economies have been able to withstand the impact of selective lockdown measures. But we can see from the new emergency brakes on air travel that there will be ramifications for the price of oil," said Chris Scicluna, head of economic research at Daiwa.
European stocks plunged 2.7%, on track for their worst day since September 2020, with travel and leisure stocks particularly badly hit.
Germany's DAX sank 3% and Britain's FTSE 100 fell 2.7% to its lowest in more than a month.
MSCI's index of Asian shares outside Japan fell 2.2%, its sharpest drop since August.
Casino and beverage shares were hammered in Hong Kong, while travel stocks dropped in Sydney and Tokyo.
Japan's Nikkei skidded 2.5% and S&P 500 futures were last down 1.8%.
Giles Coghlan, chief currency analyst at HYCM, a brokerage, said the closure of the U.S. market for the Thanksgiving holiday Thursday had exacerbated moves.
"We need to see how transmissible this variant is, is it able to evade the vaccines - this is crucial," Coghlan said.
"I expect this story to drag on for a few days until scientists have a better understanding of it."
Oil prices slid, with U.S. crude futures down 5.7% to $73.96 a barrel and Brent crude down 4.66% to $78.38 amid fresh demand fears.
As investors dashed for safe-haven assets, the yen jumped more than 1% to around 113 per dollar, having languished earlier this week at five-year lows.
The euro rose 0.4% to $1.1251, as safety rather than policy differentials drove trade.
The single currency, however, fell to near 6-1/2 year lows against the Swiss franc at 1.044 francs per euro.
"You shoot first and ask questions later when this sort of news erupts," said Ray Attrill, head of FX strategy at National Australia Bank in Sydney.
South Africa's rand fell 2% to a one-year low and its 2030 bond yield soared 25.5 basis points (bps).
Bond yields move inversely to price.
Other bond markets strengthened, benefiting from their safe haven status. Ten-year Treasury yields fell 11 bps to 1.5277% and 30-year yields were down 9 bps to
1.8777%. Germany's 10-year bond yield was down 6.2 bps at -0.31%. Gold rose 0.7% to $1,800 an ounce.
The market swings come against a backdrop of already growing concern about COVID-19 outbreaks driving restrictions on movement and activity in Europe and beyond.
European countries have expanded COVID-19 booster vaccinations and tightened curbs. Slovakia announced a two-week lockdown, the Czech government will shut bars early and Germany crossed the threshold of 100,000 COVID-19-related deaths.
"I don't think there's any going back to the pre-COVID-19 world," said Mark Arnold, chief investment officer at Hyperion Asset Management in Brisbane.
"We're just going to get mutations through time and that's going to change the way people operate in the economy. That's just reality."